Gonarthrosis Clinical Trial
Official title:
Three vs Six Gy in Gonarthrosis and Coxarthrosis. Non Inferiority Study
This is a non-inferiority study in which the investigators compare two low-dose radiotherapy
schemes, which are recommended from DEGRO Clinical Practice Guidelines (3 Gy vs 6 Gy) for the
treatment of osteoarthritis and other osteodegenerative disorders.
A first randomization will be carried out among the patients included in the study:
- Patients in arm A will be treated at 3 Gy (0.5 Gy/fraction, 3 fractions/week), and
patients in arm B will be treated at 6 Gy (1 Gy/fraction, 3 fractions/week).
- Patients should not know the arm to which they have been randomized.
- Once the treatment is finished, patients will be assessed at 8 weeks. If pain does not
improve, a re-irradiation will be performed. If the patients were treated with 3 Gy a
new randomization will be performed (3 vs 6 Gy again). If the patiens were treated with
6 Gy they will be re-irradiated with 6 Gy again.
The investigators will analyze the results obtained depending on the dose received and
depending on the location of the treatment.
Painfull skeletal disorders are susceptible to be treated with low-dose radiotherapy. DEGRO
guidelines recommend a dose between 3 and 6 Gy at 0'5 Gy/fraction or 1 Gy/fraction
respectively. The investigators want to verify that both treatments (3 and 6 Gy) are similar
to improve the pain and function in patiens with gonarthrosis and coxarthrosis, and there are
no differences between both treatments, therefore, 3 Gy is not less than 6 Gy.
In this context, a prospective multicenter study is proposed. The study will include 338
patients to assess the efficacy of low dose irradiation (3 vs 6 Gy) in gonarthrosis and
coxarthrosis.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT05233930 -
Total Knee Arthroplasty and Augmented Reality-based Navigation System
|
N/A | |
Not yet recruiting |
NCT04460989 -
Assessment of Patient Satisfaction After Arthroplasty: A Comparative Study by Implant Type
|
||
Recruiting |
NCT02411097 -
Role of Femoral Nerve Block on Prevention of Postoperative Deep Venous Thromboembolism
|
N/A | |
Not yet recruiting |
NCT05435690 -
Evaluation of a New Navigation System in Computer-assisted Total Knee Arthroplasty
|
N/A | |
Completed |
NCT06308887 -
Comparison of Ultrasound-Guided Perimeniscal Steroid and 5% Dextrose Injections in Knee Osteoarthritis
|
Phase 4 | |
Recruiting |
NCT03951545 -
Clinical and Radiological Impact of Tibial Cutting Int Total Knee Arthroplasty, Accelerated Navigation Versus Extramedullary Targeting
|
N/A | |
Recruiting |
NCT06302075 -
Functional Recovery After Medial Monocompartmental Knee Prosthesis: One Day Protocol Versus Fast Protocol
|
N/A | |
Not yet recruiting |
NCT05877027 -
Exercise vs. Topical Diclofenac vs. PRP
|
N/A | |
Completed |
NCT04577521 -
The Safety and Efficacy of Single IA-HA Injection in Patients With Knee Osteoarthritis: A Prospective Study
|
||
Recruiting |
NCT05814471 -
Validation orthèse Pour Gonarthrose
|
N/A | |
Completed |
NCT01773226 -
Evaluation of Intra-articular Injection of Autologous Protein Solution ("APS(TM)") for the Treatment of Osteoarthritis (OA)
|
N/A | |
Completed |
NCT02638831 -
Ketorol Gel in Gonarthrosis and Low Back Pain
|
Phase 4 | |
Completed |
NCT02977936 -
Management of Joint Pain Associated With Osteoarthritis of the Knee With Association of Plant Extracts.
|
||
Recruiting |
NCT05062109 -
Multimodal Geriatric Pre-authorization Before Scheduled Orthopedic Surgery
|
N/A | |
Not yet recruiting |
NCT06314191 -
Adipose Tissue and Symptomatic Gonarthrosis
|
N/A | |
Recruiting |
NCT02251535 -
In-vivo Comparison of Different Levels of Femoral Rollback in a Primary Total Knee Arthroplasty
|
N/A | |
Active, not recruiting |
NCT03734315 -
Routine Application of Ostenil® in Patients With Gonarthrosis
|
||
Completed |
NCT03389607 -
The Role of SCUBE-1 in Ischemia-reperfusion Injury
|
||
Completed |
NCT04225182 -
Evaluation of the Effectiveness of a Muscular Strengthening Protocol With an Instrumented Orthosis for Gonarthrosis Patients
|
N/A | |
Recruiting |
NCT04313894 -
WHARTON JELLY ORIGINATED MESENCHIAL STEM CELL in GONARTHROSIS
|
Phase 2 |