Glucose Intolerance Clinical Trial
Official title:
Dietary Inducers of Glyoxalase-1 for Prevention and Early-stage Alleviation of Age Related Health Disorders Through Functional Foods.
The purpose of this study is to determine whether dietary inducers of glyoxalase 1 are effective in improving metabolic and vascular health.
The aim of the study is to evaluate dietary inducers of glyoxalase 1 for effects on
metabolic and vascular health in overweight volunteers at risk of developing type 2
diabetes. The research objectives are:
(i) To evaluate dietary inducers of glyoxalase 1 for effects on markers of glucose
metabolism during an oral glucose tolerance test (oGTT), (ii) To evaluate dietary inducers
of glyoxalase 1 for effects on vascular function on three levels, using finger fold
capillary density by capillaroscopy (FFCD), arterial stiffness by aortal pulse wave velocity
(aPWV) and flow mediated dilatation (FMD); and effects on metabolic and pro-inflammatory
markers in circulating blood and urine.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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