| Eligibility |
Inclusion Criteria:
1. Evidence of IDH1 R132 mutation (any solid tumor) or circulating tumor DNA IDH2 R140 or
IDH2 R172 mutation (cholangiocarcinoma only) as determined by molecular testing
performed at a CLIA, ISO/IEC, CAP, or other similarly certified laboratory. For
cholangiocarcinoma, chondrosarcoma, and glioma, molecular testing can be performed on
tumor tissue or circulating tumor DNA. For all other solid tumor types, molecular
testing must be performed on tumor tissue.
2. Availability of an archived tumor tissue sample. Patients without an available
archival tumor tissue sample must be discussed with the sponsor's Medical Monitor
prior to enrollment.
3. Eastern Cooperative Oncology Group (ECOG) 0-1.
4. At least 18 years of age.
5. Adequate organ function.
6. Ability to swallow capsules or tablets.
7. Ability to comply with outpatient treatment, laboratory monitoring, and required
clinic visits for the duration of study participation.
8. For cholangiocarcinoma patients, must have adequate biliary drainage (per
investigator's discretion), with no evidence of ongoing infection.
9. Willingness of men and women of reproductive potential to observe conventional and
effective birth control for the duration of treatment and for 3 months following the
last dose of study treatment. Patients enrolled to Dose Expansion Cohort 4 shall also
follow cisplatin/gemcitabine contraception duration requirements as determined by
labels and/or local guidelines. Patients enrolled in dose expansion Cohort 5 should
follow durvalumab contraception duration requirements as determined by the durvalumab
label and/or local guidelines.
Monotherapy Dose Escalation:
10. A locally advanced or metastatic solid tumor, where standard curative or palliative
measures are no longer effective or are not considered appropriate or safe in the
opinion of the investigator.
11. Measurable or non-measurable disease as determined by RECIST 1.1 or RANO as
appropriate by tumor type.
12. Prior IDH1 inhibitor treatment is permitted.
Monotherapy Dose Expansion Cohort 1:
13. Histologically or cytologically confirmed diagnosis of advanced or metastatic
cholangiocarcinoma, following 1 to 2 lines of prior systemic treatment for advanced
disease. Prior IDH1 inhibitor treatment is not permitted.
14. Measurable disease as determined by RECIST 1.1.
Monotherapy Dose Expansion Cohort 2:
15. A locally advanced or metastatic solid tumor (except for cholangiocarcinoma), where
standard curative or palliative measures are no longer effective or are not considered
appropriate or safe in the opinion of the investigator.
16. Measurable disease as determined by RECIST 1.1 or RANO as appropriate by tumor types.
Monotherapy Dose Expansion Cohort 3:
17. A locally advanced or metastatic solid tumor, where standard curative or palliative
measures are no longer effective or are not considered appropriate or safe in the
opinion of the investigator.
18. Non-measurable disease only as determined by RECIST 1.1 or RANO as appropriate by
tumor type.
Combination Dose Expansion Cohort 4:
19. Histologically or cytologically confirmed diagnosis of advanced or metastatic
cholangiocarcinoma, not eligible for curative resection.
20. No prior systemic therapy for advanced or metastatic disease with the following
exceptions:
- Patients who received adjuvant chemotherapy are eligible, if the adjuvant therapy
was completed at least 6 months prior to the development of advanced or
metastatic disease.
- Patients who are receiving up to two cycles of cisplatin plus gemcitabine as the
first line systemic therapy while waiting for results of molecule profiling
including IDH1/IDH2 mutational status, are eligible, provided that a radiographic
assessment during screening demonstrates the absence of interval disease
progression since initiation of chemotherapy treatment, and all other eligibility
criteria are met.
21. Measurable disease as determined by RECIST 1.1.
Combination Dose Expansion Cohort 5:
22. Cholangiocarcinoma patients with IDH1 R132, IDH2 R140, or IDH2 R172 mutations
23. Histologically or cytologically confirmed diagnosis of advanced or metastatic
cholangiocarcinoma, following 1 or more lines of prior systemic treatment for advanced
disease.
24. Measurable disease as determined by RECIST 1.1
Exclusion Criteria:
1. Had an investigational agent or anticancer therapy within 2 weeks; or investigational
monoclonal antibody within 4 weeks prior to planned start of LY3410738.
2. Had major surgery within 4 weeks prior to planned start of LY3410738.
3. Had radiotherapy with a limited field of radiation for palliation within 7 days of the
first dose of study treatment, except for patients receiving whole brain radiotherapy,
which must be completed at least 4 weeks prior to the first dose of study treatment.
4. Patients with cholangiocarcinoma: underwent hepatic radiation, chemoembolization and
radiofrequency ablation, radioembolization or other locoregional therapy <4 weeks,
have history of hepatic encephalopathy of any grade, have ascites requiring
intervention such as diuretics or paracentesis, have ongoing cholangitis, have mixed
hepatocellular biliary tract cancer histology or history of liver transplant.
5. Have active CNS metastases are not eligible. Patients with asymptomatic and treated
brain metastases may participate provided that they are stable and are not requiring
steroid treatment. Patients with suspected or confirmed leptomeningeal disease are not
eligible even if treated.
6. Have primary CNS tumors are eligible provided that they do not have leptomeningeal
disease and are on a stable or decreasing steroid dose for 7 days prior to screening.
Patients with evidence of intracranial hemorrhage either by MRI or CT are not eligible
7. Any unresolved toxicities from prior therapy greater than CTCAE (version 5.0) Grade 2
at the time of starting study treatment except for alopecia.
8. Have clinically significant, uncontrolled cardiac, cardiovascular disease or history
of myocardial infarction within 6 months prior to planned start of study treatment.
9. Have active uncontrolled systemic bacterial, viral, fungal or parasitic infection
(except for fungal nail infection), or other clinically significant active disease
process which in the opinion of the investigator and the sponsor makes it undesirable
for the patient to participate in the trial. Screening for chronic conditions is not
required.
10. Known active hepatitis B virus (HBV). Note: Controlled (treated) hepatitis will be
allowed if they meet the following criteria, antiviral therapy for HBV must be given
for at least 1 month prior to first dose of study drug, and HBV viral load must be
less than 2000 IU/ml (104 copies/ml) prior to the first dose of study drug. Those on
active HBV therapy with viral loads under 2000 IU/ml (104 copies/ml) should stay on
the same therapy throughout the study treatment (Appendix E).
11. Known active hepatitis C virus (HCV). Note: Untreated patients with chronic infection
by HCV are allowed on study. In addition, successfully treated patients with chronic
infection by HCV (defined as sustained virologic response SVR12 or SVR24) are allowed,
as long as a minimum of 4 weeks has elapsed between achieving sustained viral response
(SVR12 or SVR24) and starting study drug.
12. Known human immunodeficiency virus (HIV); excluded due to potential drug-drug
interactions between anti-retroviral medications and LY3410738.
13. Current treatment with certain strong cytochrome P450 3A4 (CYP3A4) inhibitors or
inducers (Appendix F) and/or P-gp inhibitors (Appendix G).
14. Clinically significant active malabsorption syndrome or other condition likely to
affect gastrointestinal absorption of the study drug.
15. Active second malignancy unless in remission and with life expectancy > 2 years. Refer
to protocol exclusion criteria (Section 4.2) for examples of allowed second
malignancies.
16. Pregnancy, lactation or plans to breastfeed during the study or within 3 months of the
last dose of study intervention.
17. Patients with known hypersensitivity to any component of LY3410738 or its formulation.
Combination Dose Expansion Cohort 5:
18. Prior treatment with anti-PD 1 or anti-PD L1 therapies.
19. History of Grade 3 or higher immune-related adverse events (irAEs).
20. Active autoimmune disease that has required systemic anti-autoimmune treatment in the
past 2 years.
Endocrine replacement therapy is not considered a form of systemic therapy and is
allowed.
21. Current or prior use of immunosuppressive medication within 28 days before the first
dose of durvalumab, with the exception of intranasal and inhaled corticosteroids or
systemic corticosteroids which should not exceed 10 mg/day of prednisone or equivalent
corticosteroid.
22. Active interstitial lung disease or history of noninfectious pneumonitis Grade 2 or
higher that required treatment with systemic corticosteroids or immunosuppressive
drugs.
23. History of hypersensitivity to durvalumab or any excipient.
24. Has received a live vaccine within 30 days prior to the first dose of study drug.
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