Glioblastoma Clinical Trial
Official title:
Analysis of Different Circulating Immune Cells in Patients With Recurrent Glioblastoma or Mixed Anaplasic Glioma Treated With Bevacizumab and Search for a Link With Response to Treatment
Bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF), is an
antiangiogenic treatment currently proposed to recurrent high grade glioma patients.
Unfortunately some patients fail to respond to this treatment and finding biological factors
allowing the discrimination between potential responders and non responders would be very
helpful. As the immune system plays a key role in angiogenesis induction and maintenance in
cancer, it could serve as a surrogate marker of angiogenesis in cancer patients.
The purpose of this study is to determine the influence of bevacizumab treatment on
circulating immune cells in high grade glioma patients and to search for a link between the
variation of these cells and the response to treatment.
The following leucocyte subsets will be analyzed in whole blood before treatment and before
cycles 3, 5 and 7:
- Classical, intermediate, nonclassical and Tie2 expressing monocytes.
- Regulatory T cells (Treg).
- Myeloid Derived Suppressor cells (MDSCs) The variation of the absolute numbers (or
relative percentages) of the cells in the blood of patients will be correlated to the
response to treatment assessed according to the RANO criteria.
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