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Clinical Trial Summary

This study is a single-arm, open-label, phase II study of anlotinib combined with radiation in the treatment of patients with malignant brainstem glioma. Twenty five patients will be enrolled in the study who is diagonsis with malignant brainstem glioma. The primary objective includes disease control rate (DCR), the role of antinib combined with radiotherapy in improving quality of life and 6-month progression-free survival rate. The secondary objective include overall survival (OS), toxicity profile. Exploratory objectives include the use of plasma specimens and cerebrospinal fluid (if possible) to detect biomarkers predicting the efficacy of anlotinib.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04668508
Study type Interventional
Source Zhejiang Cancer Hospital
Contact Yuanyuan Chen, Professor
Phone +8613738103808
Email chenyy@zjcc.org.cn
Status Recruiting
Phase Phase 2
Start date November 24, 2020
Completion date January 1, 2023

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