Comparison of Aqueous Humor Adipokines in Glaucoma Patients and Healthy Controls

Glaucoma Clinical Trial

Official title:

Comparative Analysis of Aqueous Humor Adipokines in Patients With Glaucoma and Healthy Controls

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06190119
• Other study ID #: IRB00006761-M2023196
• Status: Recruiting
• Start date: October 8, 2023
• Est. completion date: April 1, 2024

Study information

• Verified date: December 2023
• Source: Peking University
• Contact: Ziyao Xia, M.D.
• Phone: +8618810838416
• Email: emilyhsia[@]163.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to observe whether there are differences in adipokines in the aqueous humor between patients with primary open-angle glaucoma (POAG) and healthy controls

Description:

1. Inclusion criteria: Patients aged 18 years or older, diagnosed with primary open-angle glaucoma (POAG) and healthy controls (who underwent cataract surgery).

2. Exclusion criteria:

1. Other Ocular Diseases: Patients with concurrent ocular diseases such as macular degeneration, retinal detachment, etc., are excluded.

2. Ocular Surgery History: individuals who have undergone intraocular or laser surgery within the past 6 months, except for uncomplicated cataract surgery.

3. History of Ocular Trauma or Inflammation

4. Systemic Diseases or Mental Disorders: Patients with systemic diseases(e.g., diabetes, rheumatoid arthritis) and those with mental disorders are excluded.

5. Pregnancy or Lactation: Females who are pregnant or lactating are excluded.

6. Presence of any retinal or optic nerve disease other than glaucoma.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 2
• Est. completion date: April 1, 2024
• Est. primary completion date: December 31, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 85 Years

Eligibility

Inclusion Criteria:

• Patients aged 18 years or older, diagnosed with primary open-angle glaucoma (POAG) and healthy controls (who underwent cataract surgery).

Exclusion Criteria:

• Other Ocular Diseases: Patients with concurrent ocular diseases such as macular degeneration, retinal detachment, etc., are excluded.

• Ocular Surgery History: individuals who have undergone intraocular or laser surgery within the past 6 months, except for uncomplicated cataract surgery.

• History of Ocular Trauma or Inflammation

• Systemic Diseases or Mental Disorders: Patients with systemic diseases(e.g., diabetes, rheumatoid arthritis) and those with mental disorders are excluded.

• Pregnancy or Lactation: Females who are pregnant or lactating are excluded.

• Presence of any retinal or optic nerve disease other than glaucoma.

Related Conditions & MeSH terms

• Adipokines
• Glaucoma

Intervention

Other:
• none intervention
This study has no intervention

Locations

Country	Name	City	State
China	Peking University Third Hosipital	Beijing	Beijing

Sponsors (2)

Lead Sponsor	Collaborator
Peking University	Beijing Tongren Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Concentration of adipokines in aqueous humor	Aqueous humor samples were assessed for adipokines and inflammatory cytokines by Luminex bead-based multiplex array	Cross-sectional baseline