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Glaucoma, Suspect clinical trials

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NCT ID: NCT06388096 Recruiting - Glaucoma, Suspect Clinical Trials

CLAD Deconvolved PERG Responses in Glaucoma Patients

Start date: June 1, 2023
Phase: N/A
Study type: Interventional

Glaucoma is a progressive disease resulting in blindness. Determining the onset of the disease is critical so patients may obtain treatment to preserve useful vision. This study will collect data from a population of glaucoma suspects (with positive factors for the disease but with normal vision) along with a population of age matched controls using the pattern electroretinogram (PERG) and other standard eye tests for glaucoma. The PERG measures the function of retinal ganglion cells (RGCs) which come together to form the optic nerve. RGCs may become dysfunctional before dying. The Continuous loop deconvolution technique (CLAD) will be used to extract transient PERG responses in both glaucoma suspects and age matched controls. All patients will be monitored with PERG, Optic Coherence Tomography (OCT) and other ancillary tests over 2 years. CLAD will be compared with conventional techniques of monitoring glaucoma (standard PERG, OCT, visual field etc) to see if the CLAD is better at distinguishing between glaucoma suspects and controls.

NCT ID: NCT05850936 Recruiting - High Myopia Clinical Trials

Effect of IOP Lowering on Progressive HM

Start date: June 1, 2023
Phase: N/A
Study type: Interventional

Currently, whether and when intraocular pressure (IOP) lowering medication should be used in progressive high myopia (HM) to control axial elongation is still a dilemma. Randomized trials are required to evaluate whether IOP lowering influences the growth of axial length in progressive HM eyes.

NCT ID: NCT05686421 Completed - Glaucoma Clinical Trials

Comfortable and Stabilizing Chin & Forehead Rest Attachment for Slit Lamp Configurations

Start date: March 30, 2023
Phase: N/A
Study type: Interventional

In this study, participants will be imaged using two Optical Coherence Tomography (OCT) devices: device N, a standard conventional OCT device with an invention (comfortable chin and forehead rest that can be adjusted to fit each individual's size) attached to the device; and device C, the standard conventional OCT device with no invention attached. The investigators will assess whether the chin and forehead rest attachment (invention) provides a more comfortable experience for patients.

NCT ID: NCT05670015 Recruiting - Glaucoma, Suspect Clinical Trials

Ocular Changes With Alpha-2 Receptor Agonist.

Start date: January 1, 2023
Phase: N/A
Study type: Interventional

selective alpha-2 receptor agonists cause changes in intraocular pressure and pupillary size thus may affect patient quality of life.

NCT ID: NCT05352906 Recruiting - Glaucoma Clinical Trials

Accuracy of Handheld and Non-contact Tonometry

Start date: April 20, 2022
Phase: N/A
Study type: Interventional

Monitoring the intraocular pressure (IOP) is one of the most important tests used in follow-up among glaucoma suspects and confirmed glaucomatous patients.

NCT ID: NCT05328921 Recruiting - Hypertension Clinical Trials

Effects of Systemic Drugs on Intraocular Pressure

Start date: April 7, 2022
Phase:
Study type: Observational

To assess intraocular pressure changes among glaucoma patients on systemic antihypertensive and antihistaminic drugs.

NCT ID: NCT05279716 Recruiting - Ocular Hypertension Clinical Trials

Study in Prostaglandin Associated Peri-orbitopathy Switching From Prostaglandin Monotherapy to Omidenepag Isopropyl

NOPAPS
Start date: February 15, 2022
Phase: Phase 4
Study type: Interventional

This study is for patients have been using prostaglandin analogue eye drops with a preservative for 3 months or more and have been diagnosed with prostaglandin-associated peri-orbital disease. the investigators would like to confirm the real world evidence(RWE) of safety and efficacy after changing to Eybelis ophthalmic solution 0.002%.

NCT ID: NCT05235321 Recruiting - Glaucoma Clinical Trials

Automated Applanation Tonometry

Start date: November 21, 2022
Phase: N/A
Study type: Interventional

Goldmann Applanation Tonometry (GAT) is considered the clinical gold standard for eye pressure measurements and yet it is known to be a subjective measurement with limited repeatability and limited portability. The purpose of this study is to develop an automated and objective method for performing applanation tonometry using standard ophthalmic equipment as well as using 2 portable prototypes.

NCT ID: NCT04972695 Completed - Glaucoma Clinical Trials

Validation of an Automatic Analysis Algorithm of the Probability of Glaucoma From Optic Disc Images

Start date: May 7, 2021
Phase:
Study type: Observational

Clinical, cross-sectional and prospective study to assess the images of the posterior pole of the retina of patients from the Glaucoma Unit of the IOBA and the Hospital Clínico Universitario de Valladolid during the period between May and December 2021. The aim of the project is to provide a sufficient number of images from posterior pole retinographies in patients with suspected glaucoma or with diagnosis of glaucoma in order to determine the sensitivity and specificity of an automatic glaucoma screening algorithm developed by the company Transmural Biotech S.L.

NCT ID: NCT04722861 Enrolling by invitation - Glaucoma Suspect Clinical Trials

Development of the Glaucoma Visual Functioning Questionnaire-40 and Its Psychometric Properties

Start date: September 8, 2020
Phase:
Study type: Observational

The objective of this study is to develop and test the psychometric properties of a self-report questionaire, the Glaucoma Visual Functioning Questionnaire-40 (GVFQ-40), which was designed to measure the difficulty of daily activities of glaucoma patients and evaluate the effectiveness of clinical treatment or rehabilitation interventions.