Gestational Hypertension Clinical Trial
Official title:
Investigation of the Oral Microbiome in Pregnancy - do Differences in Oral Bacterial Profiles and Nitrate Metabolism Contribute to Blood Pressure Regulation in Pregnant Women?
High blood pressure in pregnancy is associated with poor outcomes for both mum and baby,
increasing the risk of pregnancy complications including pre-eclampsia, fetal growth
restriction and preterm birth. The development of new blood pressure lowering interventions
suitable for use in pregnancy is a key research priority.
Inorganic nitrate is a compound found in certain types of food, particularly green leafy
vegetables and beetroot. Nitrate provides an important source of nitric oxide (NO), a
molecule involved in keeping blood vessels healthy and regulating blood pressure.
Supplementation with nitrate in the diet, using interventions such as beetroot juice, has
been shown to reduce blood pressure and improve blood vessel function.
In order for dietary nitrate to have these beneficial effects, it needs to be converted in
the body to nitrite, via bacteria that live in the mouth (oral bacteria). Differences in oral
bacteria, and how they metabolise nitrate, are thought to influence blood pressure regulation
and potentially response to dietary nitrate supplementation.
This study aims to understand (1) whether pregnant women with high blood pressure have a
different composition of oral bacteria compared to healthy pregnant women and women who are
not pregnant, and (2) how differences in oral bacteria affect blood pressure responses to a
dose of dietary nitrate (in the form of beetroot juice).
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