Metformin Compared to Glyburide in Gestational Diabetes

Status Completed

Clinical Trial Summary

Our hypothesis is that metformin and glyburide will have equal efficacy in controlling blood glucose in gestational diabetics with no increase in adverse maternal, fetal or neonatal outcomes.

Clinical Trial Description

Pregnant women are screened with a one hour 50g glucose challenge. Women with values of 130 mg/dl or greater are then given a 100g glucose tolerance test. Two abnormal values are diagnostic of gestational diabetes. all women are initially counseled on diet and exercise. Women who fail to maintain a fasting of <105mg/dl and 2 hr postprandial < 120 mg/dl are offered participation in the study. Women were randomized to either metformin or glyburide via a computer generated randomization. Women who fail to meet glycemic goals after receiving the maximum dose of study medication were considered treatment failures and insulin therapy was initiated. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00965991
Study type	Interventional
Source	University of New Mexico
Contact
Status	Completed
Phase	N/A
Start date	July 2003
Completion date	August 2023

View Details

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