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Comparison of Metformin and Insulin for Management of Gestational Diabetes Mellitus

Gestational Diabetes Mellitus in Pregnancy Clinical Trial

Official title:
Comparison of Metformin and Insulin for Management of Gestational Diabetes Mellitus

Clinical Trial Summary

Gestational diabetic mellitus (GDM) patients randomised to metformin or insulin group.Aim was to achieve blood sugar levels of Blood sugar fasting (BSF) <5.3 mmol/l and 1 hour post meal<7.8mmol/l. Both groups were followed till delivery and outcome studied.

Clinical Trial Description

75 gm Oral Glucose Tolerance Test (OGTT) was done in pregnant patients. Blood sugar fasting(BSF) > 5.5 mmol/l & 2 hours postprandial >7.8 mmol/l was labelled as GDM. They were randomised to metformin or insulin group. Those assigned to metformin group were started metformin 500mg twice daily & increased until 2500mg depending on the blood sugar levels. Aim was to achieve blood sugar levels of BSF <5.3 mmol/l and 1 hour post meal<7.8mmol/l. If blood sugar levels were not controlled, insulin was added. The insulin group was given 3 injections of regular insulin & one intermediate acting insulin injection at night subcutaneously. Both groups were followed till delivery and outcome studied ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03320694
Study type Interventional
Source Services Institute of Medical Sciences, Pakistan
Contact
Status Completed
Phase Phase 3
Start date February 1, 2016
Completion date June 30, 2017
View Details
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