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Genetic Change clinical trials

View clinical trials related to Genetic Change.

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NCT ID: NCT06182722 Recruiting - Depressive Disorder Clinical Trials

Association of Peripheral Immune Cells With Antidepressant Treatment Response

Start date: March 13, 2024
Phase:
Study type: Observational [Patient Registry]

The purpose of this observational study is discovering potential biomarkers to predict antidepressant treatment response in patients with major depressive disorder (MDD) while comparing the transcriptomic changes between patients with MDD and healthy controls as well as before and after antidepressant treatment. Eligible patients will be assessed at Week 1, Week 2, Week 4 and Week 8 while healthy normal volunteers will only be evaluated at baseline. Assessments will include the following: an interview about mental and physical health, a physical examination including drawing of venous blood samples and several psychiatric rating scales.

NCT ID: NCT05398380 Recruiting - Colorectal Cancer Clinical Trials

Liver Transplantation for Non-resectable Colorectal Liver Metastases: Translational Research

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

The patients with non-resectable colorectal liver metastases (CRLM) have always being considered a particular subgroup of CRLM in which the therapeutic approach, is focused on strategies that allow a potential surgery like neoadjuvant systemic treatments. But, the underlying biology that causes this particular profile of spread in a proportion of patients that always recur and progress in the liver has not been properly characterized from a biological point of view. Unfortunately, these patients finally develop liver metastasis not amenable for local treatments and become refractory to systemic treatments even without developing extrahepatic liver metastases. As a result, liver transplantation (LT) is a potential for patients without extrahepatic involvement and nonresectable CRLM. There are several studies that aims to evaluate if LT increases overall survival compared to best alternative care. To our knowledge, none of these studies incorporate objectives focused on the underlying tumor biology of this particular population and the development of focused strategies including a dynamic disease monitoring and targeted treatments for this particular population.The METLIVER trial will permit to expand the genetic studies to the whole complexity of metastatic lesions and a more precise evaluation of their genetic heterogeneity. Moreover, it will help to precise the type of genetic analyses on liquid biopsies that can be designed for patients that will unfortunately relapse mostly with lung metastases after LT. Our proposal will maximize the opportunity to produce an unprecedented knowledge on CRLM evolution and will provide new opportunities for relapsed patients.

NCT ID: NCT05375331 Recruiting - Child Development Clinical Trials

Clinical and Genetic Markers of Bone Metabolism in Children Under One Year

Start date: December 31, 2020
Phase:
Study type: Observational

The study of children under one year of age for molecular genetic testing-VDR (rs1544410, rs2228570), RANKL (rs9594738, rs9594759) with the study of the frequency distribution of alleles and genotypes by polymorphisms, analysis of the relationship of molecular genetic markers with indicators of bone metabolism.

NCT ID: NCT04481061 Recruiting - Clinical trials for Knowledge, Attitudes, Practice

Engaging Adolescents in Decisions About Return of Genomic Research Results

Start date: March 10, 2020
Phase: N/A
Study type: Interventional

Recent recommendations to return children's results for adult-onset conditions to parents anytime whole exome or genome sequencing is performed, as well as growing expectations to return research results to participants on a large-scale basis, mean adolescents will increasingly be engaged in assenting (<age 18) and consenting (>age 18) to return of genomic research results. There is an urgent need to understand adolescents' informational preferences and to create ethically informed, scalable processes that empower adolescents from diverse backgrounds to participate in the decision-making process about learning genomic results. This research will provide important insights into adolescents' choices, as well as the ethical, legal and societal implications of engaging adolescents in making choices about learning genomic results in genomic research and community-based research settings.

NCT ID: NCT04216537 Recruiting - Glioma Clinical Trials

Survival Significance of Molecular Pathology and Genetic Variation in Brain Gliomas

Start date: January 1, 2018
Phase:
Study type: Observational

This study aims to collect clinical, radiological, pathological, molecular and genetic data including detailed clinical parameters, MR and histopathology images, molecular pathology and genetic data. This study seeks to find the prognostic and clinical significance based on molecular and genetic biomarkers/subgroups of gliomas.

NCT ID: NCT04110769 Recruiting - Pancreatic Cancer Clinical Trials

Development of Biomarker for the Evaluation of Response After Neoadjuvant Therapy in Patients With Pancreatic Cancer

Start date: July 17, 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to identify and apply biomarkers that can provide better information than previous imaging and blood tests when evaluating the response after neoadjuvant chemotherapy in pancreatic cancer patients who require neoadjuvant therapy before surgery.