Acute Pancreatitis Clinical Trial
Official title:
Evaluation of the Incidence and Relevance of the Adrenal Insufficiency in Critical Emergencies in Digestive Diseases (GI Bleeding and Acute Pancreatitis)
Observational study about the incidence of relative adrenal insufficiency in patients with
cirrhosis and acute variceal bleeding; in patients with acute peptic gastrointestinal
bleeding and without liver disease; and in patients with severe acute pancreatitis.
This is a study using pharmaceutical specialties in the approved conditions of use.
Observational, prospective, open-label, in-patient study, that includes patients with upper
gastrointestinal bleeding of variceal or peptic origin, and in patients with severe acute
pancreatitis.
The adrenal function of every patient included will be evaluated in the first 24 hours of
admission This assessment shall be performed using the corticotropin-stimulation short test
(synacthen test), that includes serum and saliva determination of cortisol, in basal
conditions and 30 and 60 minutes after the administration of 250 ug of corticotropin
synthetic (Synacthen, Novartis Pharma AG, Basel, Switzerland).
The cortisol levels will be determined by competitive immunoassay using direct
chemoluminescence technology (Bayer Corporation, Pittsburgh, PA, USA).
In patients with severe acute pancreatitis all of these determinations will be repeated at
the third day of admission.
Several other clinical and biochemical features will be recorded.
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Observational Model: Case-Only, Time Perspective: Prospective
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