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Gastroesophageal Reflux clinical trials

View clinical trials related to Gastroesophageal Reflux.

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NCT ID: NCT05455359 Not yet recruiting - Clinical trials for Gastro Esophageal Reflux

Gastrointestinal Dysmotility on Aspiration Risk

Start date: July 18, 2022
Phase: Phase 4
Study type: Interventional

The hypothesis of this study is that esophageal and gastric dysmotility increase the risk of developing aspiration-associated symptoms in children with neurologic impairment. The investigators are conducting a ten week cross over study comparing prucalopride to famotidine for the treatment of aspiration-associated symptoms.

NCT ID: NCT05425771 Not yet recruiting - Clinical trials for Reflux, Gastroesophageal

ARMA (Antireflux Mucosa Ablation) in Patients With Chronic Refractory Reflux Disease

ARMA
Start date: July 14, 2022
Phase: N/A
Study type: Interventional

Pilot study of the possible clinical response to anti reflux mucosal ablation in patients with chronic refractory reflux disease

NCT ID: NCT05422404 Not yet recruiting - Clinical trials for Gastroesophageal Reflux Disease

Anti-Reflux Mucosal Ablation(ARMA) and Anti-Reflux Mucosectomy(ARMS) in Gastroesophageal Reflux Disease

Start date: June 30, 2022
Phase: N/A
Study type: Interventional

According to the current published data and treatment mechanism, ARMS may led to more stenosis while ARMA may be less effective in long term follow-up. The changes of patient's life quality , UGI tract microbiota before and after different endoscopic treatment are also limited. So we want to conduct a exploratory prospective randomized controlled study in evaluating the mucosal healing, demand of PPI, life quality, emotion status, sleep quality, esophageal motility/ acid exposure and saliva microbiota between chronic GERD patients receiving ARMS and ARMA treatment.

NCT ID: NCT05369572 Not yet recruiting - Clinical trials for Artificial Intelligence

Connection Between Tongue Signs and Bile Reflux Analysed With Artificial Intelligence

Start date: June 30, 2022
Phase:
Study type: Observational

By introducing artificial intelligence into Chinese medicine tongue diagnosis, we collated and collected tongue images, anxiety and depression scales and gastroscopy reports, mined and analysed the correlation between tongue images and bile reflux and anxiety and depression and constructed a prediction model to analyse the possibility of predicting bile reflux and anxiety and depression in patients based on tongue images.

NCT ID: NCT05214079 Not yet recruiting - Oesophageal Reflux Clinical Trials

Determination of the Left Paratrachéal Force Required to Occlude the Esophageal Entrance

Start date: March 1, 2022
Phase: N/A
Study type: Interventional

Determine the force required to occlude the esophagus with a left paratracheal pressure

NCT ID: NCT05162079 Not yet recruiting - Reflux Clinical Trials

Protocol for the ESREFLUJO Study: Epidemiological Study of Heartburn and Gastroesophageal Reflux in Community Pharmacy

ES-REFLUJO
Start date: March 1, 2022
Phase:
Study type: Observational

Introduction: Symptoms as heartburn and/or reflux is frequent consultations in community pharmacies, the characterization of them is crucial to provide appropriate patient counseling. To facilitate the assistance work of the community pharmacist and its coordination between different levels of care, a group of experts in Community Pharmacy, Primary Care, and Gastroenterology has recently worked on an algorithm to manage these symptoms. Objective: Analyse the epidemiological characteristics of patients who consult for symptoms of heartburn and/or reflux in Spanish community pharmacies, and evaluate the clinical and humanistic results of the protocolization of a Professional Pharmaceutical Service in said patients. Methods and analysis: The study design consists of a cross-sectional descriptive part, in which the clinical and sociodemographic characteristics of the patients who come to the community pharmacy will be evaluated for consultation derived from heartburn and/or reflux symptoms and a before-after descriptive study in which will evaluate the clinical and humanistic results in patients who come to the pharmacy after receiving pharmaceutical care.

NCT ID: NCT05068089 Not yet recruiting - Clinical trials for Gastro-Esophageal Reflux

Health, Economic Analysis and Clinical Aspects of Patients With Neurological Disabilities in Enteral Nutrition With Dedicated Formula. The Role of Nissen's Fundoplication in the Management of Gastroesophageal Reflux

Start date: November 1, 2021
Phase:
Study type: Observational

Nutritional difficulties are common in children with neurodisabilities and can be associated with malnutrition and gastrointestinal diseases, such as gastro-esophageal reflux disease (GERD) and constipation. Neurological disorders can be divided into two main categories: progressive (neurodegenerative, mitochondrial disease) and non-progressive (cerebral palsy) neurodisabilities; nature of the disorders can impair on the nutritional status of these children. In 2017, ESGHAN published guidelines with specific nutritional claims. Approximately 46%-90% of children with neurodisabilities suffer from malnutrition and an enteral feeding is necessary to reach the nutritional requirements. In addition, a relevant issue for these children is GERD, reaching up to 70% prevalence. The treatment of GERD could be based on pharmacological therapy (protonic pomp inhibitor, PPI), on nutritional treatment (changing type of formula) or on surgical treatment (Nissen Fundoplication). European guidelines for GERD recommend PPI as the first line, with fundoplication being considered in cases of failure of optimized medical therapy. Enteral feeding can be considered in order to avoid malnutrition and is justified when other efforts to increase nutritional intake. Enteral feeding can be provided by nasal tube at the beginning, but a gastrostomy feeding tube would be preferred for a long-term nutrition (greater than six weeks). A jejunal tube can be introduced through the gastrostomy; jejunal feeding is appropriate in patients with recurrent vomiting and/or tube feeding-related aspiration, severe gastroesophageal reflux, and gastroparesis. Different types of formulas can be used for enteral nutrition and can be offered by nasal tube, percutaneous endoscopic gastrostomy (PEG) or percutaneous endoscopic jejunostomy (PEJ). Whey-based formulas have been shown to empty from the stomach more rapidly than casein-based formulas, which may be helpful for patients presenting with delayed gastric emptying. Use of peptide-based, 100% whey protein formulas are associated with improved feeding tolerance, increased consistency in meeting nutritional needs, and a reduction in gastrointestinal issues associated with vomiting and aspiration of feeds. For these reasons, the aim of this study is to retrospectively evaluate the role of different formulas against Nissen fundoplication, regarding tolerance, utility, applicability and safeness of these products, by performing a cost analysis.

NCT ID: NCT04763993 Not yet recruiting - Obesity Clinical Trials

Reflux Disease After Gastric Bypass Versus Sleeve Gastrectomy in Morbid Obese Patients: an Italian Study

ReBvSS
Start date: May 1, 2024
Phase: N/A
Study type: Interventional

The study aims to clarify if GERD, defined by results of 24 hours potential of hydrogen (pH) monitoring and abnormal DeMeester Score (DMS), in obese patients could worsen after Sleeve Gastrectomy (SG) more than after RYGBP. To demonstrate this hypothesis, the investigators will study the obese population suspected for GERD with 24 hours monitoring and High-Resolution Esophageal Manometry (HRM). DMS is calculated pre-operatively and, once GERD is confirmed, the patients are enrolled for randomization to SG or RYGBP. The suspicion of GERD is investigated with the GERDQ score and EGDS, that all obese patients have pre-operatory.

NCT ID: NCT04696783 Not yet recruiting - Clinical trials for Gastroesophageal Reflux Disease

The Effect of PPI in Preventing Gastroesophageal Reflux Disease of Seafarers

Start date: July 2021
Phase: Phase 3
Study type: Interventional

In view of the high incidence of GERD among seafarers and its continuing impact on the life quality of seafarers, it is necessary to use preventive treatment. At the same time, because both mental and psychological factors and changes in intestinal flora may play a certain role in the development and treatment of GERD, this project intends to take the seafarers involved in this scientific expedition as the participants to explore the effect of PPI discontinuous therapy in preventing gastroesophageal reflux disease of seafarers, a special occupational group and the changes in the mental and psychological status and intestinal flora of this group of people after PPI therapy.

NCT ID: NCT04652336 Not yet recruiting - GERD Clinical Trials

Study Comparing the Effect of Ligamentum Teres Cardiopexy on de Novo GERD Post LSG

Start date: December 10, 2020
Phase: N/A
Study type: Interventional

The aim of this study is to investigate the effect of ligamentum teres cardiopexy on incidence of de Novo GERD.