Diuretic Effect of Metolazone Pre-dosing Versus Concurrent Dosing

Status Terminated

Clinical Trial Summary

The purpose of this study is to examine whether administering metolazone 60 minutes prior to furosemide increases urine output compared with administering metolazone and furosemide concomitantly. Participants will have equal chance of being assigned to each group.

Clinical Trial Description

Diuretic resistance is common among patients with acute decompensated heart failure, and one strategy for overcoming this phenomenon is sequential nephron blockade with loop plus thiazide-type diuretics. Metolazone is an oral thiazide-type diuretic commonly used for this purpose. Due to its delayed absorption, some clinicians suggest that metolazone be given 30-60 minutes prior to the loop diuretic. However, the efficacy and safety of such a strategy has not been investigated despite its added complexity. The purpose of this study is to investigate whether pre-dosing with metolazone confers a difference in efficacy and safety compared to administering it at the same time as furosemide. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03746002
Study type	Interventional
Source	University of Maryland, Baltimore
Contact
Status	Terminated
Phase	Phase 4
Start date	January 1, 2019
Completion date	January 10, 2020

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