Fever Clinical Trial
— ELISAOfficial title:
Link Between Eosinopenia and Bacterial Infections in the Elderly Subject Hospitalized in Geriatrics
NCT number | NCT04363138 |
Other study ID # | 2020-A00301-38 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | July 2, 2021 |
Est. completion date | August 1, 2022 |
Verified date | January 2023 |
Source | Gérond'if |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The main purpose of this monocentric, non-interventional, prospective study carried out in acute geriatrics (UGA) and post-rehabilitation care, is to determine if eosinopenia is associated with bacterial infections.
Status | Completed |
Enrollment | 156 |
Est. completion date | August 1, 2022 |
Est. primary completion date | August 1, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 75 Years and older |
Eligibility | Inclusion Criteria: - Hospitalized in Geriatrics. - First episode of: - Fever> 38 ° motivating the realization of a biological assessment. - Or Leukocytes> 10 g / l and C reactive protein (CRP) > 20 mg / l. - Be affiliated to a social security scheme. - No oral opposition to participation in the study and use of the data. Exclusion Criteria: - Immunosuppression (HIV with CD4 <200 / mm3) - Active corticosteroid therapy - Asthma - Chemotherapy, immunosuppressive treatment - Malignant hematological disease, lympho or myeloproliferative syndrome - Antibiotic therapy initiated before entering the geriatric ward - Documented parasitosis - Eosinophilic vasculitis - stroke <30 days - Patient already included in another study - Patient under guardianship or curatorship - Not affiliated with a social security scheme - Oral opposition to participation in the study |
Country | Name | City | State |
---|---|---|---|
France | Geriatric Department, Paul Brousse Hospital | Villejuif | Ile-de-France |
Lead Sponsor | Collaborator |
---|---|
Gérond'if |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Determine if eosinopenia is associated with bacterial infections by measuring eosinophil counts. | 1 month | ||
Secondary | Determine if eosinopenia is associated with the effectiveness of antibiotics by measuring eosinophil counts. | 1 month | ||
Secondary | Determine if the eosinophil counts (PNE) / neutrophil (PNN)x1000 < 4 ratio is associated with a bacterial infection by measuring this value. | 1 month | ||
Secondary | Determine if eosinopenia is associated with mortality by measuring eosinophil counts. | 1 month | ||
Secondary | Determine if deep eosinopenia is associated with bacterial involvement by measuring if this value is less than 10 per mm3. | 1 month. |
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