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Non-invasive Detection of Male Infertility With FDG-PET/MRI (Spectroscopy and DWI)

Fertility Disorders Clinical Trial

Official title:
Non-invasive Detection of Male Infertility With FDG-PET/MRI (Spectroscopy and DWI)

Clinical Trial Summary

The aim of the study is to examine the value of the new MRI techniques (spectroscopy and DWI), and FDG-PET in prognostication of male infertility.

Clinical Trial Description

The diagnostic workup of male infertility includes medical history, physical examination and semen analysis. In severe cases further workup includes testicular ultrasound, analysis of genes and hormones and in a few cases testicular biopsies are necessary. Ultrasound is the first choice of imaging, but new MRI and PET techniques can provide additional information. Research indicates that new MRI techniques can measure the activity of the testicular sperm cell production non-invasively and FDG-PET can measure the testicular metabolism with a radioactively marked glucose analog (FDG). These imaging modalities are combined in a PET/MRI and we wish to perform a PET/MRI in 10 men with normal sperm counts and 10 men with low sperm counts in order to evaluate whether a PET/MRI can distinguish testicles with and without sperm cell production. We hope that this new non-invasive technique can replace the need for invasive biopsies and will be able to target the harvesting of sperm cells in fertility treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03250195
Study type Interventional
Source Rigshospitalet, Denmark
Contact
Status Terminated
Phase N/A
Start date August 7, 2017
Completion date August 7, 2021
View Details
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