Dexmedetomidine to Levobupivacaine for Transversus Abdominis Plane Block

Status Completed

Clinical Trial Summary

The perioperative management of pain following abdominal surgery can pose a challenge to anesthesia providers. Conventional practice has involved the use of opioids as well as neuraxial analgesic techniques. Unfortunately, these therapies are not without potential risks and side effects. These include nausea, vomiting, pruritus, urinary retention, constipation, respiratory depression, and sedation.

Clinical Trial Description

As a result, the goal to reduce perioperative pain has taken on a multimodal approach. Multimodal or "balanced" analgesia uses a combination of opioid and nonopioid analgesics to improve pain control and minimize opioid-related side effects. These include the use of nonsteroidal anti-inflammatory drugs, local anesthetics, peripheral nerve blocks, gabapentinoids, and alpha2 adrenergic agonists. Any combination of these therapies can help reduce the surgical stress response and improve patient outcomes such as pain control, patient satisfaction, time to discharge, and return to daily activities. One method used in this multimodal approach is the transversus abdominis plane block. As first described by Rafi in 2001, this block provides analgesia to the anterolateral abdominal wall. In 2007, further studied this technique in patients undergoing large-bowel resection. He discovered a reduction in postoperative pain and morphine consumption in the first 24 hours postoperatively, resulting in fewer opioid-mediated side effects. In this same year, Hebbard described the use of ultrasound guidance to provide real-time imaging of the muscle layers and needle placement to improve TAP block accuracy. In 2008, Hebbard. described the subcostal approach of TAP blocks, to target the nerves of the upper abdomen. Transversus abdominis plane blocks continue to be studied and developed as an effective method for providing analgesia for numerous types of abdominal surgeries. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04971759
Study type	Interventional
Source	Assiut University
Contact
Status	Completed
Phase	Phase 2/Phase 3
Start date	December 1, 2019
Completion date	February 1, 2021

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04577430` - Effects of Dexmedetomidine on Cardiac Electrophysiology in Patients Under General Anesthesia During Perioperative Period	N/A
Completed	`NCT03220880` - Intranasal Dexmedetomidine Sedation in Children for Non-painful Procedures
Completed	`NCT05291364` - Dexmedetomidine in Splanchnic Nerve Neurolysis	N/A
Recruiting	`NCT05249153` - Dexmedetomidine and Sufentanil Effect in PCA on Pediatric Patients Undergoing Scoliosis Surgery	N/A
Completed	`NCT01688648` - Comparison Between Lidocaine, Dexmedetomidine, and Their Combined Infusion in Subjects Undergoing Coronary Artery Bypass Graft	N/A
Completed	`NCT05103735` - Propofol-remifentanyl Versus Dexmedetomidine in Awake Craniotomy: Impact on Electroclinical Seizure Activity
Recruiting	`NCT06030804` - Perioperative Dexmedetomidine and Long-term Survival After Cancer Surgery	N/A
Terminated	`NCT03253224` - Magnesium and Postoperative Pain	Phase 4
Recruiting	`NCT06210061` - Propofol-Fentanyl-Dexmedetomidine and Propofol-Fentanyl-Sevoflurane Anesthesia for Major Spine Surgery Under Somato Sensory- and Motor- Evoked Potential Monitoring	N/A
Recruiting	`NCT05525819` - Intrathecal Versus Intravenous Dexmedetomidine in Prostate Transurethral Resection	N/A
Completed	`NCT04665453` - Dexmedetomidine and Melatonin for Sleep Induction for EEG in Children	N/A
Completed	`NCT06018948` - Effect of Two Different Doses of Dexmedetomidine Infusion in Morbidly Obese Patients	Phase 4
Completed	`NCT03658421` - Dexmedetomidine as Adjuvant for FNB in TKA	N/A
Completed	`NCT03775655` - Low Dose Hyperbaric Bupivacaine and Dexmedetomidine as an Adjuvant, Caesarean Section	Phase 2/Phase 3
Completed	`NCT03234660` - Dexmedetomidine and Neuroprotection in Children Undergoing General Anesthesia	N/A
Completed	`NCT06020781` - Efficacy and Safety of Dexmedetomidine to Bupivacaine in Supraclavicular Brachial Plexus Block	N/A
Recruiting	`NCT06207331` - Effects of Atomized Dexmedetomidine on Lung Function in Patients With Chronic Obstructive Pulmonary Disease	N/A
Active, not recruiting	`NCT03629262` - Dexmedetomidine Supplemented Intravenous Analgesia in Elderly After Orthopedic Surgery	Phase 4
Recruiting	`NCT06098209` - Dexmedetomidine and Propofol in Mechanically Ventilated Patients by Using Salivary Alpha-amylase as a Stress Marker	N/A
Not yet recruiting	`NCT06062550` - Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery	Phase 4

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Dexmedetomidine to Levobupivacaine for Transversus Abdominis Plane Block in Elderly Patients Undergoing Inguinal Hernia Repair Surgery

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms