Female Infertility Clinical Trial
Official title:
An Open-label Prospective Controlled Study to Assess the Effect of Intrauterine Adminstration of HCG Versus Endometrial Injury by Pipelle on the Ongoing Pregnancy Rate in Patients With Unexplained Infertility Undergoing Ovulation Induction
Our study aims to describe the effect of the intrauterine adminstration of HCG versus the endometrial injury by pipelle on the ongoing pregnancy rate and the biochemical pregnancy rate in women with unexplained infertility undergoing ovulation induction. Also to describe the effect on the first trimester miscarriage rate, ectopic pregnancy rate, and multiple pregnancy.This study is an open-label, prospective, controlled study, multi-center study. The study participants' relevant medical records will be collected and reviewed after obtaining informed consent for the participants. The study materials that will be used will include blood tests, and ultrasound. The study will involve three study arms.
Our study aims to describe the effect of the intrauterine adminstration of HCG versus the endometrial injury by pipelle on the ongoing pregnancy rate and the biochemical pregnancy rate in women with unexplained infertility undergoing ovulation induction. Also to describe the effect on the first trimester miscarriage rate, ectopic pregnancy rate, and multiple pregnancy.This study is an open-label, prospective, controlled study, multi-center study. The study participants' relevant medical records will be collected and reviewed after obtaining informed consent for the participants. The study materials that will be used will include blood tests, and ultrasound. The study will involve three study arms: Arm 1: Women with unexplained infertility undergoing ovulation induction following intrauterine adminstration of HCG on the day of trigger Arm 2: Women with unexplained infertility undergoing ovulation induction following endometrial injury by pipelle on day 8-9 of the same cycle of ovulation induction Arm 3: Women with unexplained infertility undergoing ovulation induction following intrauterine adminstration of placebo on the day of trigger Primary and secondary key measurements will be used in the study. The primary measures will include: - Signs of ongoing pregnancy Presence of intrauterine gestational sac at 12 weeks Presence of fetal heart pulsation at 12 weeks - Two serum β-HCG levels in 48hrs interval to emphasis biochemical pregnancy The secondary key measures will include: - Occurance of abortion in the 1st trimester - Appearance of ectopic pregnancy diagnosis by: Ultrasound Serum β-HCG level Symptoms of pain and bleeding - Signs of multiple pregnancy Number of intrauterine gestational sacs Number of fetal poles Number of fetal heart pulsations - Recording the the baseline characteristics of the study participants ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT06239051 -
Greening the Humanitas Fertility Center: How to Build a More Sustainable Medical Daily Routine
|
||
| Recruiting |
NCT05179993 -
Detection of Microplastics in Human Granulosa Cells and in the Follicular Fluid of Women Undergoing ICSI Treatment
|
||
| Recruiting |
NCT03767569 -
Myo-inositol as Pretreatment in Hyperandrogenic PCOS Patients
|
Phase 3 | |
| Completed |
NCT03737253 -
Hormone Evaluation in Artificial Reproductive Technology
|
Phase 4 | |
| Not yet recruiting |
NCT02237755 -
Clomiphene Citrate in Combination With Gonadotropins for Ovarian Stimulation in Women With Poor Ovarian Response.
|
Phase 2/Phase 3 | |
| Not yet recruiting |
NCT02237781 -
Levels of Anti-Mullerian Hormone (AMH) During Ovarian Stimulation With Gonadotropins
|
Phase 2/Phase 3 | |
| Completed |
NCT01477073 -
Multiple Dose FSH-GEX(TM) in Healthy Volunteers
|
Phase 1 | |
| Recruiting |
NCT00119925 -
'SPRING'-Study: "Subfertility Guidelines: Patient Related Implementation in the Netherlands Among Gynaecologists"
|
N/A | |
| Recruiting |
NCT06098495 -
Looking for a Blood Epigenetic Signature to Predict Female Infertility
|
||
| Completed |
NCT03998553 -
Study for Obtaining Mature Oocytes by in Vitro Maturation in Oocyte-donor Women
|
N/A | |
| Completed |
NCT05189145 -
Hormonal Monitoring and Progesterone Adjustment in Frozen Embryo Transfer Cycles
|
N/A | |
| Completed |
NCT01620346 -
Intracytoplasmic Morphologically Selected Sperm Injection and Advanced Maternal Age
|
N/A | |
| Completed |
NCT00315029 -
Patient-Centered Implementation Trial for Single Embryo Transfer
|
N/A | |
| Recruiting |
NCT03080584 -
Effect of 12 Weeks of Acupuncture on AMH and COH in Low Responder Patients
|
N/A | |
| Not yet recruiting |
NCT05106712 -
Vitamin D Supplementation and Improvement of PCOS Therapy and IVF Outcomes in Infertile Saudi Women
|
N/A | |
| Recruiting |
NCT06041204 -
Best Treatment for Women With Both (Polycystic Ovary Syndrome) PCOS and Subclinical Hypothyroidism
|
N/A | |
| Completed |
NCT02328924 -
There is a Value of Luteinizing Hormone Predictive of in Vitro Fertilization Treatment Outcome in Antagonist Protocols?
|
Phase 4 | |
| Completed |
NCT01604044 -
Highly Purified Menotropin (HP-hMG) Versus Recombinant FSH (rFSH) Plus Recombinant LH (rLH) in Intrauterine Insemination Cycles in Women ≥35 Years: a Prospective Randomized Trial.
|
Phase 1 | |
| Completed |
NCT04019899 -
Myo-inositol and Vitamin D3 During IVF
|
N/A | |
| Completed |
NCT02454829 -
Follow-up of Ovarian Function in Young Women Who Underwent Ovarian Cortex Cryopreservation
|
N/A |