Female Infertility Clinical Trial
Official title:
Study for Obtaining Mature Oocytes by in Vitro Maturation in Oocyte-donor Women
In vitro maturation (IVM) is a technique for obtaining potentially fertilizable oocytes from
immature oocytes. An oocyte must be mature both nuclearly and cytoplasmically in order to be
competent in the reproductive process. Nuclear maturation involves an oocyte in metaphase II
stage and is easily evaluated for its morphology. However, cytoplasmic maturation can only be
evaluated by in vitro fertilization of that oocyte A mature nuclear and cytoplasmic oocyte is
one capable of producing a viable embryo. This study aims to fine-tune the in vitro
maturation (IVM) technique to achieve nuclear mature oocytes, i.e., to mature the oocytes up
to the metaphase II stage. In addition, an artificial oocyte activation (AOA) will be carried
out to check the cytoplasmic maturation of the oocytes, avoiding the generation of
potentially viable embryos.
The aim of this study is to evaluate the response to the strategy stimulation with highly
purified human menopausal gonadotropin (hMG-HP) administered for three days, in association
with a standard methodology of in vitro oocyte maturation (IVM), to be performed on oocyte
donors.
The correct functioning of this IVM technique would mean a reduction in the costs of ovarian
stimulation treatments, as lower doses and shorter stimulation times are required, which
implies lower risks for women derived from the medication and less stress for them.
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