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Clinical Trial Summary

Febrile seizures are one of the most common clinical diseases in pediatric neurology. It occurs between 6 months and 6 years of age and occurs in ~2-5% of children. According to the age, frequency, duration, and type of seizures FS is divided into simple febrile seizures and complex febrile seizures Differentiation between febrile seizures and non-ictal events associated with fever such as shivering or dizziness is challenging. Therefore, precise diagnosis of FS after paroxysmal episodes associated with fever is often hindered by the lack of an objective biomarker With the widespread application of technologies, such as molecular biology, in medicine, some biomarkers for predicting or diagnosing FS have attracted attention. Imuekemhe et al in 1989 and 1996 found that lactic acid in the serum and cerebrospinal fluid of children with FS was significantly increased . Arginin-vasopressin hormone AVP released by the pituitary gland, has been shown to be involved in the thermoregulatory response to fever and convulsions Although AVP is unstable in the peripheral blood and, therefore, unsuited for diagnostic use the C-terminal portion of the AVP precursor copeptin has been recognized as a robust marker of AVP secretion . Wellman et al. found that the serum copeptin and Von Willebrand factor of children with FS were significantly higher than those of the control group .


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05215366
Study type Observational
Source Sohag University
Contact Mahmoud A abd elrady, resident
Phone 01276923636
Email mahmoud011175@med.sohag.edu.eg
Status Recruiting
Phase
Start date January 7, 2022
Completion date August 15, 2022

See also
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Completed NCT01694524 - Nervous System Infections Among Patients With Febrile Seizure N/A
Not yet recruiting NCT05947006 - Study of the Impact of a Pediatric Nurse's Consultation on Parental Anxiety During a Febrile Convulsion in Children N/A
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Completed NCT04967066 - A Cross-Sectional Study of Serum Levels of Adipocytokines in Children With Febrile Seizures
Terminated NCT01370044 - Carbon Dioxide (Carbogen) for the Treatment of Febrile Seizures Phase 2/Phase 3