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Clinical Trial Summary

Febrile seizures are one of the most common clinical diseases in pediatric neurology. It occurs between 6 months and 6 years of age and occurs in ~2-5% of children. According to the age, frequency, duration, and type of seizures FS is divided into simple febrile seizures and complex febrile seizures Differentiation between febrile seizures and non-ictal events associated with fever such as shivering or dizziness is challenging. Therefore, precise diagnosis of FS after paroxysmal episodes associated with fever is often hindered by the lack of an objective biomarker With the widespread application of technologies, such as molecular biology, in medicine, some biomarkers for predicting or diagnosing FS have attracted attention. Imuekemhe et al in 1989 and 1996 found that lactic acid in the serum and cerebrospinal fluid of children with FS was significantly increased . Arginin-vasopressin hormone AVP released by the pituitary gland, has been shown to be involved in the thermoregulatory response to fever and convulsions Although AVP is unstable in the peripheral blood and, therefore, unsuited for diagnostic use the C-terminal portion of the AVP precursor copeptin has been recognized as a robust marker of AVP secretion . Wellman et al. found that the serum copeptin and Von Willebrand factor of children with FS were significantly higher than those of the control group .


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05008458
Study type Observational
Source Sohag University
Contact mahmoud a abd elrady, resident
Phone 01276923636
Email mahmoud011175@med.sohag.edu.eg
Status Not yet recruiting
Phase
Start date September 1, 2021
Completion date May 15, 2022

See also
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Not yet recruiting NCT05947006 - Study of the Impact of a Pediatric Nurse's Consultation on Parental Anxiety During a Febrile Convulsion in Children N/A
Recruiting NCT05215366 - Value of Copeptin Assay in Children With Febrile Seizures at Sohag University Hospital
Completed NCT03165981 - Fever After Simultaneous Versus Sequential Vaccination in Young Children Phase 4
Completed NCT04967066 - A Cross-Sectional Study of Serum Levels of Adipocytokines in Children With Febrile Seizures
Terminated NCT01370044 - Carbon Dioxide (Carbogen) for the Treatment of Febrile Seizures Phase 2/Phase 3