Fatigue Clinical Trial
Official title:
Fatigue and Skeletal Muscle Impact in Severe Axial Spondylarthritis
Axial spondyloarthropathy (SpA) is the most common inflammatory rheumatism (1% of the general
population) with important medico-economic consequences.
Fatigue is a major feature of SA. It can be defined as a feeling of reduced muscle capacity,
lack of energy and exhaustion. The fatigue reaches an abnormally high level (fatigue severity
score (FSS) ≥4, called severe fatigue in this protocol) in more than two thirds of patients
with SA.
Skeletal muscle repercussions are present during SA. It is characterized by a decrease in
exercise capacity independently of pain and ankylosis but is associated with a decrease in
strength and muscle mass, the importance of which varies from one study to another.
The link between fatigue (subjective sensation) and the skeletal muscular impact (objective)
of SA has never been studied.
This work will:
1. • To study for the first time the implication of the objective skeletal muscular impact
in fatigue during SA.
2. • To better characterize the skeletal muscle impact of SA;
3. • To characterize the evolution of the fatigue and the muscular impact under anti-TNFα
treatment and the predictive factors of response,
4. • To identify new therapeutic targets for these two complications of SA, which currently
have no specific treatment.
;
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