Fatigue Clinical Trial
Official title:
Exploration of the Neuromuscular Mechanisms Associated With Sunitinib Related Fatigue
The purpose of this research study is to determine how sunitinib (sunitinib malate) causes fatigue. Patients will be asked to complete a brief questionnaire (survey) to rate their levels of fatigue every two weeks while they are participating in this research study. The questionnaire takes approximately 10-15 minutes to complete and is 9 questions. A series of physical measurements for fatigue will be performed before the first dose of sunitinib and again (4) weeks later to see if there are any changes in physical level of fatigues
PRIMARY OBJECTIVES:
I. To determine the mechanisms associated with sunitinib related fatigue by recording EMG
signals during a submaximal elbow contraction, twitch force and TMS prior to and at the end
of 4 weeks of sunitinib in metastatic RCC patients.
OUTLINE:
Patients receive sunitinib malate orally (PO) daily for 4 weeks. Patients undergo
neuromuscular testing at baseline and on day 28 and complete fatigue assessment at baseline
and on days 14 and 28.
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