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Ventilation Support for the PREvenTion of EXTubation Failure — PRETEEXT  

Extubation Failure Clinical Trial

Official title:
Evaluation of an Oxygenation and Ventilation Support Protocol for the PREvenTion of EXTubation Failure: a Stepped Wedge Cluster Randomized Trial

Clinical Trial Summary

Reintubation after failed extubation would be associated with increased mortality. Therefore, extubation failure remains a major concern in ICU. Few randomized controlled studies have assessed the benefit for a systematic respiratory support (noninvasive ventilation or high flow nasal cannula) applied at the time of extubation to reduce reintubation rates in patients at high and low risk for reintubation. In addition, these studies reported discordant results. Therefore, there are some concerns regarding effectiveness and systematic uptake of a respiratory support after extubation into usual practice.

Clinical Trial Description

The aim of this trial is to determine whether a protocolized postextubation respiratory support including High-flow Nasal Oxygen (HFNO) and Noninvasive Ventilation (NIV) could reduce the rate of reintubation in comparison with usual practice. Therefore, all consecutively eligible patients for the study, will be assigned to a protocol arm in accordance with the randomized period ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05550259
Study type Interventional
Source University Hospital, Caen
Contact
Status Not yet recruiting
Phase N/A
Start date October 2022
Completion date February 2024
View Details
See also
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