Experimental Lung Inflammation Clinical Trial
Official title:
Validation of a Lung Inflammation Model in Healthy Volunteers by Radiological Tools and Glucocorticoid Treatment
The purpose of this study is to investigate the local and systemic inflammatory response and
haemostatic alterations in the lungs after lipopolysaccharide (LPS) instillation and to
determine the feasibility of imaging techniques to quantify lung inflammation in an adapted
human endotoxin instillation model.
The investigators will also explore whether glucocorticoid treatment can blunt LPS effects.
n/a
Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Basic Science