Physiological Outcomes of High-intensity Interval Training With Post-exercise Blood Flow Restriction

Exercise Performance Clinical Trial

Official title:

Physiological Outcomes of High-intensity Interval Training With Post-exercise Blood Flow

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT05835557
• Other study ID #: IRB-2023-235
• Status: Active, not recruiting
• Phase: N/A
• Start date: July 1, 2023
• Est. completion date: September 30, 2024

Study information

• Verified date: April 2024
• Source: Nanyang Technological University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This research study revolves around the physiological outcomes of using post-exercise blood flow restriction (BFR) with high intensity short interval training (ST) The main aims of this study are to compare (i) aerobic performance outcomes, and (ii) anaerobic and muscular performance outcomes - between 2 groups of participants after either undergoing 3 weeks of ST + post-exercise BFR (BFR-ST) or traditional ST.

Description:

This research study revolves around the physiological outcomes of using post-exercise blood flow restriction (BFR) with high-intensity interval exercise training (HIIT), specifically high intensity short interval training (ST) protocol of 30s work, 30s rest, for the recreational endurance athlete. In previous research, it has been shown that using BFR during rest intervals of a ST protocol would elicit greater physiological stresses in terms of higher heart rate, greater muscle activation, reduced oxygenation within the muscle tissue during exercise, and increased blood lactate post-exercise as compared with the control condition. However, the physiological outcomes of this type of training method over a longer-term (9 sessions over 3 weeks) have not been explored. The main aims of this study is to compare the physiological outcomes, - (i) aerobic performance outcomes, and (ii) anaerobic and muscular performance outcomes - between 2 groups of participants after either undergoing 3 weeks of ST + post-exercise BFR (BFR-ST) or traditional ST . The hypotheses for this study are: the BFR-ST group would experience a (i) greater improvement in maximal aerobic capacity, function and time trial performance and, (ii) greater improvement in anaerobic power and capacity as well as muscular strength and power, as compared with the ST group.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 40
• Est. completion date: September 30, 2024
• Est. primary completion date: September 30, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Male

• 18-40 years

• Actively performing endurance exercise (running or cycling) for at least 2 sessions (1
• 1.5h) per week

• Healthy (free from illnesses) and no musculoskeletal injuries for the past 6 months

• No history of cardiometabolic, vascular diseases or similar conditions (e.g., high blood pressure, peripheral vascular diseases, heart diseases, metabolic syndrome, diabetes, stroke, etc.).

• Pass the pre-participation health screening tests - Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) and Australian Institute of Sport Blood Flow Restriction (AIS BFR) pre-screening questionnaire (no history of any risk factors).

• Achieve a maximum oxygen uptake (VO2max) of =40ml/kg/min during a maximal aerobic power cycling screening test.

• Non-smoker

• Drink alcohol less than 3 times each week and less than 3 drinks each time

Exclusion Criteria:

• Persons with any form of illnesses and/or musculoskeletal injuries for the past 6 months

• Any history of cardiometabolic, vascular diseases or similar conditions which may worsen with the use of blood flow restriction during exercise

• Fail the pre-participation health screening tests

• Below 40ml/kg/min VO2max during maximal aerobic power cycling test

• Smoker

• Consumption of alcohol beyond that stated in the inclusion criteria.

• History of asthma or taking medication for asthma.

Related Conditions & MeSH terms

• Exercise Performance

Intervention

Other:
• BFR-ST
Undergo 9 sessions of high intensity short interval training involving 3 sets of 8-10 repetitions of 30 secs interval cycling and 30 secs recovery at 100-110% of maximal aerobic power. In between sets there will be 3 mins of passive rest. Blood flow restriction will be applied for 2 mins during the passive rest at 80% of limb occlusion pressure.
• ST
Undergo 9 sessions of high intensity short interval training involving 3 sets of 8-10 repetitions of 30 secs interval cycling and 30 secs recovery at 100-110% of maximal aerobic power. In between sets there will be 3 mins of passive rest. Cycling will be conducted in an environmental chamber and participants informed that the altitude is set to 2500m - actual altitude will be sea level.

Locations

Country	Name	City	State
Singapore	Human Bioenergetics Laboratory, National Institute of Education, Nanyang Technological University	Singapore

Sponsors (1)

Lead Sponsor	Collaborator
Nanyang Technological University

Country where clinical trial is conducted

Singapore, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Maximum oxygen uptake and power		Will be assessed at baseline (Day 0 - Pre) and the change in this outcome 24 hours after 9 sessions of training over 3 weeks (Post)
Primary	20 km Cycling time trial		Will be assessed at baseline (Day 0 - Pre) and the change in this outcome 24 hours after 9 sessions of training over 3 weeks (Post)
Primary	Wingate test of anaerobic power	Peak and mean power and rate of fatigue	Will be assessed at baseline (Day 0 - Pre) and the change in this outcome 24 hours after 9 sessions of training over 3 weeks (Post)
Secondary	Exercise economy	Oxygen uptake at a fixed load of 50% of maximum aerobic power	Will be assessed at baseline (Day 0 - Pre) and the change in this outcome 24 hours after 9 sessions of training over 3 weeks (Post)
Secondary	Isometric mid-thigh pull	Maximal strength assessment of lower body	Will be assessed at baseline (Day 0 - Pre) and the change in this outcome 24 hours after 9 sessions of training over 3 weeks (Post)
Secondary	Countermovement jump height	Vertical jump height assessment	Will be assessed at baseline (Day 0 - Pre) and the change in this outcome 24 hours after 9 sessions of training over 3 weeks (Post)