Ketosis Clinical Trial
Official title:
Can Ketone Supplementation Enhance Exercise Performance?
The purpose of this study is to observe the effects of exogenous ketone supplements during shorter bouts of exercise testing on twenty collegiate endurance trained athletes (18-25 years of age).
Some believe very high fat diets (>70% energy) can enhance exercise performance by providing additional fuel (ketones) for energy metabolism, at least for very prolonged exercise (>3-4h). Regardless, this diet is difficult to maintain so it has been suggested that ingesting ketone salts along with a normal carbohydrate (CHO) diet might be more practical. The purpose of this study is to observe the effects of ketone salt ingestion on shorter term (up to ~15 min) exercise performance. Endurance trained (≥2 year training experience; ≥7 h/week) collegiate athletes (n=20) of similar body mass (♀; 55-60kg; ♂; 75-80kg) and age 18-25y) consuming 5-6g CHO•kg-1•d-1) will be tested before and after 1 and 7d of ketone salt (Prüvit, Carrollton TX, US) supplementation (0.6-0.8g•kg-1•d-1). Participants will perform two exercise performance tests (a 10km cycle time trial and a 30s Wingate cycle test on separate days) before and after supplementation. Blood samples (glucose, lactic acid, and ketone concentration) will be taken at: baseline and following each performance test. It is hypothesized that ketone salt supplementation will increase blood ketone concentration but will not enhance these exercise performance tests. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04477161 -
Effect of Ketone Esters in Parkinson's Disease
|
N/A | |
| Active, not recruiting |
NCT05477368 -
Examining the Feasibility of Prolonged Ketone Supplement Drink Consumption in Adults With Type 2 Diabetes
|
N/A | |
| Completed |
NCT04817176 -
MI-CBT Adherence Program for Lifestyle Interventions in Older Adults
|
Early Phase 1 | |
| Completed |
NCT04565444 -
Ketones and Muscle Protein Synthesis
|
N/A | |
| Active, not recruiting |
NCT06097754 -
Intermittent Exogenous Ketosis (IEK) at High Altitude
|
N/A | |
| Terminated |
NCT03790436 -
Betaquik as an Adjunct to Dietary Management of Epilepsy in Adults on the Modified Atkins Diet
|
N/A | |
| Completed |
NCT03299543 -
Comparison Between Breath Acetone and Blood Beta-Hydroxybutyrate
|
||
| Recruiting |
NCT04004676 -
Ketone Supplementation, Glycogen Replenishment and Time Trial Performance Following Glycogen Lowering Exercise
|
N/A | |
| Not yet recruiting |
NCT03659825 -
Ketone Esters for Optimization of Cognitive Performance in Hypoxia
|
N/A | |
| Active, not recruiting |
NCT04156477 -
Markers of Appetite Regulation During Exogenous Ketosis
|
N/A | |
| Completed |
NCT04130724 -
Characterization of a Portable Solid-State Breath Acetone Testing Device for Real-Time Ketosis Status
|
||
| Recruiting |
NCT04594265 -
Weight-Adjusted Dosing of 3-OHB in Patients With Chronic Heart Failure
|
Phase 2 | |
| Not yet recruiting |
NCT04576026 -
Exogenous Ketone Supplementation and Cognitive Function During Exercise
|
N/A | |
| Completed |
NCT05558488 -
The Effect of a Meatless,Keto Restrictive Diet on Body Composition,Strength Capacity,Oxidative Stress,Immune Response
|
N/A | |
| Recruiting |
NCT03564002 -
Metabolic Effects of Very Low Carbohydrate Ketogenic Diet in Subjects With Severe Obesity
|
||
| Completed |
NCT04309214 -
Market Research - Acceptability Study for New MCT Fat Products
|
N/A | |
| Completed |
NCT05588427 -
Effect of Ketone Ester Supplementation on Hypoxic Tolerance
|
N/A | |
| Recruiting |
NCT05656339 -
Metabolic Effects of Whey Protein Supplementation After Fasting in Volunteers
|
N/A | |
| Active, not recruiting |
NCT04737694 -
Ketone Supplements and Substrate Oxidation and Physical Performance
|
N/A | |
| Completed |
NCT04309149 -
Market Research - Acceptability Study for a Range of MCT Products
|
N/A |