Effects of High-Intensity Interval Training (HIT) While in a Hyperoxic-Hyperbaric Environment on Exercise Performance

Exercise Performance Clinical Trial

— HITOP  

Official title:

Effects of High-Intensity Interval Training (HIT) While in a Hyperoxic-Hyperbaric Environment on Exercise Performance (HITOP Study)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02941939
• Other study ID #: 1050188
• Status: Completed
• Phase: N/A
• Start date: April 14, 2016
• Est. completion date: June 8, 2017

Study information

• Verified date: May 2018
• Source: Intermountain Health Care, Inc.
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Hyperbaric oxygen has previously been tested as a possible means for pre-conditioning to enhance exercise performance. This study is designed to examine the effects of exercising in a hyperbaric chamber for improving fitness when combined with high-intensity training.

Description:

The purpose of this research study is to determine the incremental benefit of high intensity interval training (HIT) in a hyperbaric-hyperoxic environment with HIT alone in healthy subjects and to compare the effect of HIT at an intermediate altitude (SLC, UT; altitude 1420 m) with that performed at sea-level (Durham, NC) in healthy subjects. While VO2 max is determined by the functional interdependence of the respiratory, cardiovascular and muscular systems, ultimately VO2 max is determined by mitochondrial oxidative capacity. Exercise training increases mitochondrial capacity. There is evidence that high intensity interval training (HIT) programs are effective at increasing exercise capacity. Furthermore, there is evidence that training while in a hyperbaric-hyperoxic environment may potentiate the HIT training effect through its effects on mitochondrial oxidative capacity, but this has not been scientifically tested. Our hypothesis is that high intensity interval training (HIT) in a hyperoxichyperbaric environment performed six-times over a two-week period will increase exercise performance compared with HIT performed in ambient conditions in healthy subjects. The primary outcome studied will be the effect of high-volume interval training in a hyperbaric-hyperoxic on VO2max.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: June 8, 2017
• Est. primary completion date: April 8, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Healthy individuals, ages 18-40 years that are sedentary or recreationally active but not involved in any structured endurance training will be eligible for the study. This level of activity will be defined as performing mild-moderate aerobic exercise 0-3 times per week.

• VO2 max within normal limits (defined as 84-120% predicted using Wasserman reference equations48).

• Spirometry within predicted limits.

Exclusion Criteria:

• Subjects unable to complete a satisfactory VO2 max test

• Individuals with chronic cardiovascular disease such as hypertension, valve disease, coronary artery disease, cardiac conduction abnormalities, etc.

• History of pneumothorax or chronic lung disease such as asthma, COPD, bronchiectasis

• Active Smokers

• Pregnant women

• Persons unable to read or understand English, not in full mental capacity or suffer from blindness.

Related Conditions & MeSH terms

• Exercise Performance

Intervention

Other:
• Hyperbaric chamber

• Ambient pressure

Locations

Country	Name	City	State
United States	Intermountain Medical Center	Murray	Utah

Sponsors (1)

Lead Sponsor	Collaborator
Intermountain Health Care, Inc.

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in maximum VO2 at 2 weeks compared to baseline	Comparison of post-training VO2 results with baseline in the two HIT groups (performed at ambient conditions in Salt Lake City, UT and hyperbarichyperoxic conditions); the results of HIT at Salt Lake City, UT altitude will be compared with those performed at sea-level altitude in Durham, NC.	2 weeks
Secondary	Change in VO2 measured at anaerobic threshold (in mL O2/kg/min) at 2 weeks compared to baseline	Difference post-training minus pre-training	2 weeks
Secondary	?VO2/?WR (in mL O2/kg/min/Watt; a measure of exercise efficiency)	Difference post-training minus pre-training	2 weeks
Secondary	Change in peak work rate (in Watts) at 2 weeks compared to baseline	Difference post-training minus pre-training	2 weeks
Secondary	Change in heart rate response to exercise at 2 weeks compared with baseline	Difference post-training minus pre-training	2 weeks
Secondary	Change in level of perceived exertion at 2 weeks compared with baseline	Difference post-training minus pre-training	2 weeks
Secondary	Change in Borg dyspnea score at 2 weeks compared with baseline	Difference post-training minus pre-training	2 weeks