Exercise Induced Asthma Clinical Trial
Official title:
Diagnostics of the Quality of Life With Exercise Induced Asthma (EIA) and Exercise Induced Laryngeal Obstruction (EILO)
The purpose of this study is to investigate the quality of life of subjects suffering from dyspnoea while exercising and quantify the number of diagnoses of Exercise induced Asthma (EIA) and Exercise induced laryngeal obstruction (EILO) in our outpatient clinic using an exercise-challenge in a cold-chamber and an exercise-challenge with continuous laryngoscopy.
In this study investigators want to characterize and investigate the quality of life of all
patients consulting the outpatient clinic for pediatric pulmonology suffering from dyspnoea
while exercising.
Besides standard diagnostics (bodyplethysmograph, spirometry, exhaled NO, skin prick test)
subjects will take part in an exercise-challenge in a cold chamber at 2-4°C. Subjects showing
symptoms of exercise-induced asthma will get a treatment with ICS/LABA for six weeks. All
Patients should fill out a symptom diary. On suspicion of an EILO, subjects not showing
symptoms in the first exercise-challenge in the cold chamber and all subjects without
improvement after EIA treatment will take part in a second exercise-challenge in the cold
chamber with continuous laryngoscopy.
If EILO is proved by laryngoscopy, speech therapy is recommended. To investigate the symptoms
and the quality of life of these patients, all patients and there parents should answer
symptom and quality of life questionnaires (Child Behavior Checklist (CBCL/4-18), Youth
Self-Report (YSR 11-18), Asthma Control Test, (ACT) Dyspnea Index (DI)) at every visit.
There are yearly follow ups of these patients for five years in order to collect long-range
prognosis.
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