Effect of Aerobic Exercise in Patients With Essential Hypertension

Essential Hypertension Clinical Trial

Official title:

Effects of Supervised Versus Unsupervised Aerobic Exercise Training on Weight Loss, Functional Capacity, Quality of Life and Depression Level in Patients With Essential Hypertension

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05987436
• Other study ID #: HKara2
• Status: Completed
• Start date: November 1, 2017
• Est. completion date: December 1, 2019

Study information

• Verified date: August 2023
• Source: TC Erciyes University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The goal of this observational study is to evaluate the effects of a supervised aerobic exercise training program on weight loss, functional capacity, quality of life (QoL), and depression levels in patients with essential hypertension.

Description:

Patients who chose the treatment type according to personal preferences were divided into two groups: Group 1(n:91) exercised for six weeks, five sessions per week under the supervision of a medical doctor in the aerobic exercise laboratory, and group 2(n:47) was advised to maintain dietary habits and physical activity levels. Body weight, serum lipid levels, functional capacity, QoL, and depression level of all the participants were evaluated at baseline and 6 weeks later.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 138
• Est. completion date: December 1, 2019
• Est. primary completion date: April 1, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• Over 18 years of age,
• Absence of concomitant other metabolic and cardiovascular diseases.

Exclusion Criteria:

• Having suffered an event of ischaemic heart disease (<6 months),
• Secondary hypertension,
• Hypertrophic obstructive cardiomyopathy,
• Congestive heart failure,
• Uncontrolled cardiac arrhythmia,
• Thyroid dysfunction,
• Diabetes mellitus,
• Symptomatic peripheral arterial occlusive disease,
• Aortic insufficiency or stenosis,
• Pulmonary or heart disease with dyspnoea at small or moderate effort,
• An outbreak of orthopedic problems on hip, knee or ankles, such as arthroplasty, contracture or severe osteoarthritis,
• Using of antidepressant or anxiolytic drugs,
• Pregnancy,
• Cognitive disfunction.

Related Conditions & MeSH terms

• Aerobic Exercise
• Essential Hypertension
• Hypertension

Intervention

Other:
• Supervised Aerobic Exercise
Group 1 exercised for six weeks, five sessions per week under the supervision of a medical doctor in the aerobic exercise laboratory.

Locations

Country	Name	City	State
Turkey	Selcuk University Faculty of Medicine	Konya

Sponsors (1)

Lead Sponsor	Collaborator
TC Erciyes University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Body weight	kilograms	was measured at the pre-treatment period and the post-treatment 6th week for all the participants by the same physician.
Primary	Blood samples	Serum total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, very-low-density lipoprotein (VLDL) cholesterol, and triglycerides	Twelve-hour fasting blood samples were collected between 6.00 am, and 10.00 am at baseline and week 6.
Primary	The functional capacity	The 6MWT test and the estimated metabolic equivalents or METs were used performed to evaluate functional capacity.	6MWT was assessed in face-to-face interviews before and immediately after the treatment was completed.
Primary	Quality of Life	Quality of life was assessed with Short Form-36 (SF-36).	SF36 was assessed in face-to-face interviews before and immediately after the treatment was completed.
Primary	Depression level	Depression level was assessed Beck Depression Inventory (BDI).	BDI was assessed in face-to-face interviews before and immediately after the treatment was completed.