Loaded Breathing Training in Essential Hypertension

Essential Hypertension Clinical Trial

Official title:

Effects of Loaded Breathing Training on Blood Pressure in Essential Hypertensive Patients

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT00791986
• Other study ID #: KKU-475090015-0
• Status: Terminated
• Phase: N/A
• First received: November 14, 2008
• Last updated: March 5, 2018
• Start date: May 2006
• Est. completion date: December 2008

Study information

• Verified date: March 2018
• Source: Khon Kaen University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine whether adding load to slow controlled breathing training could enhance blood pressure lowering in patients with essential hypertension.

Description:

Hypertension (HT) is one of the major risk of cardiovascular diseases and cost of pharmacological treatment is a very high. Lifestyle modification is the first trial in stage 1 hypertension before commencing pharmacological treatment and a co-treatment with drug in hypertensive patient. Slow paced breathing training and physical training has been shown to reduce both systolic and diastolic blood pressure in HT. Moreover loaded breathing was reported to be able to decrease blood pressure in healthy. Loaded slow breathing training may enhance the antihypertensive effect of slow paced breathing.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 30
• Est. completion date: December 2008
• Est. primary completion date: December 2007
• Accepts healthy volunteers: No
• Gender: All
• Age group: 35 Years to 65 Years

Eligibility

Inclusion Criteria:

• Clinical diagnosis of essential hypertension stage I-II

Exclusion Criteria:

• Respiratory disease

• Diabetes mellitus

• Heart disease

• Renal disease

• Cerebrovascular disease

• Dyslipidemia

• Pregnancy

Related Conditions & MeSH terms

• Essential Hypertension
• Hypertension
• Respiratory Aspiration

Intervention

Device:
• ULB , LB
ULB: The patients breath in slowly without resistance via the water pressure threshold breathing (WPTB) device, 30 min/day, 7 days/week for 8 weeks. LB : The patients breath in slowly against resistance of 20 cmH2O provided by the water pressure threshold breathing (WPTB) device, 30 min/day, 7 days/week for 8 weeks.

Locations

Country	Name	City	State
Thailand	Cardiopulmonary Physical Therapy Research Room, Faculty of Asociated Medical Sciences, Khon Kaen University.	Khon Kaen

Sponsors (2)

Lead Sponsor	Collaborator
Khon Kaen University	Thai health promotion foundation.

Country where clinical trial is conducted

Thailand, 

References & Publications (1)

- Seals DR, Suwarno NO, Joyner MJ et al.Respiratory modulation of muscle sympathetic nerve activity in intact and lung denervated humans. Circulation Research 72(2): 440-454,1993. - Rosenthal T, Alter A, Peleg E, Gavish B. Device-guided breathing exercises reduce blood pressure: ambulatory and home measurements. Am J Hypertens 14(1):74-76,2001. - Viskoper R, Shapira I, Priluck R et al.Nonpharmacologic treatment of resistant hypertensive by device-guided slow breathing exercises. Am J Hypertens 16(6): 484-487,2003. - Grossman E, Grossman A, Schein MH et al.Breathing-control lowers blood pressure. J Hum Hypertens 15(4): 263-269,2001. - Viskoper R, Shapira I, Priluck R et al.Nonpharmacologic treatment of resistant hypertensive by device-guided slow breathing exercises. Am J Hypertens 16(6):484-487,2003 - Meles E, Giannattasio C, Failla M. et al.Non-pharmacologic treatment of hypertension by respiratory exercise in the home setting. Am J Hypertens 17(4):370-374,2004.

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Home blood pressure		Pre- and post - 8 weeks of intervention at rest
Secondary	Office blood pressure		Pre- and post- 8 weeks of intervention at rest
Secondary	Exercising blood pressure		Blood pressure during exercise at pre- and post-8 weeks of intervention
Secondary	Heart rate variability		Heart rate variability at pre-and post- 8 weeks of intervention