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Clinical Trial Summary

Assessment of blood ammonia level as a non-invasive predictor for presence of EV and risk of bleeding


Clinical Trial Description

A prospective cross sectional study on 150 consecutive patients screening for esophageal varices.

Patient groups groups:

Group (1): 100 patients with esophageal varices

Group (2): 50 chronic liver disease patients with no esophageal varices as a control group.

All patients will be subjected to:

1. - Detailed history-taking

2. - Full clinical examination

3. - Laboratory investigations:

- Complete blood picture (CBC)

- Erythrocyte sedimentation rate (ESR)

- Renal function tests

- Liver function tests

- Prothrombin time and activity

- Viral markers (HCV Ab - HBV Ag)

- Blood ammonia level.

4. - Pelviabdominal US: Ultrasound examination of the liver, portal venous system, spleen, kidney and other abdominal organs.

5. - Upper GITendoscopy:

- Varices will be classified according to the Japanese classification 1996,

- The Baveno 11 score will be used to differentiate between mild and severe portal hypertensive gastropathy. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03212872
Study type Interventional
Source Tanta University
Contact Ferial El-Kalla, MD
Phone 00201006023289
Email f.elkalla@gmail.com
Status Recruiting
Phase N/A
Start date July 7, 2016
Completion date December 31, 2018

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