Brain Metabolism Observed at 7 Tesla

Status Recruiting

Clinical Trial Summary

The goal is to develop methodology to monitor flux in the citric acid cycle in brain via 13C nuclear magnetic resonance (NMR) spectroscopy at 7 Tesla.

Clinical Trial Description

The goal is to establish a protocol to 13C-label (from 13C-glucose) several physiological molecules: glucose, lactate, pyruvate and derived compounds. All of these molecules can undergo oxidation in the citric acid cycle. The intent is to study the 13C labeling pattern of these molecules in control and G1D subjects to determine if downstream products (such as 13C bicarbonate or 13C glutamate) due to oxidation in the mitochondria can be detected in brain or in blood by NMR analysis. While inside the instrument, the subjects may also undergo a 7T MR exam to correlate spectroscopy with brain structure. ;

Study Design

Related Conditions & MeSH terms

Carbohydrate Metabolism, Inborn Errors
Epilepsy
Glucose Metabolism Disorders
Glucose Transport Defect
Glucose Transporter Protein Type 1 Deficiency Syndrome
Glucose Transporter Type 1 Deficiency Syndrome
Glut1 Deficiency Syndrome 1, Autosomal Recessive
Metabolic Diseases
Syndrome

Clinical Trial Details

NCT number	NCT05085704
Study type	Observational
Source	University of Texas Southwestern Medical Center
Contact	Juan M Pascual, M.D.
Phone	214-648-4591
Email	rare.diseases@utsouthwestern.edu
Status	Recruiting
Phase
Start date	May 3, 2022
Completion date	September 20, 2026

View Details

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