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Clinical Trial Summary

Non-specific protective effects resulting from the BCG vaccine appear to be paternally inheritable. Since the BCG vaccine is known to induce trained immunity, epigenetics might explain the fathers' contribution to the immune profile of their offspring. Epigenetic inheritance in mice has recently been demonstrated, but is not established in humans yet. By studying the DNA methylation profile of sperm cells after BCG vaccination, we aim to gain insight into the possibility of epigenetic inheritance in human males.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05766345
Study type Interventional
Source Radboud University Medical Center
Contact
Status Active, not recruiting
Phase Phase 4
Start date October 2, 2023
Completion date October 2024

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