Epigenetics Clinical Trial
Official title:
The Influence of Epigenetic Modification in OPRM1 on Postoperative Analgesia and Side Effect Induced by μ-opioid Receptor Agonists
To explore the epigenetic mechanism of postoperative analgesia and side effect induced by μ-opioid Receptor Agonists presented with sufentanil among general population.
Patients were interviewed the day before surgery, and taught about the use of PCA pump and
VAS. Pressure pain threshold(PPT) and pressure pain tolerance(PTO) were collected before
surgery.
Dexmedetomidine1μg/Kg，sufentanil 0.5μg/Kg， propofol 2mg/Kg and rocuronium 0.6mg/Kg were
given intravenously for induction. Anesthesia was maintained with inhalation of 1%
sevoflurane and infusion of remifentanil (0.2-0.4ug/kg/min) and propofol (6-10mg/kg/h).
Aterial blood pressure(ABP)，central venous pressure(CVP)，SPO2， HR，ETCO2，T and Narcotrend
were monitored. Before incision, parecoxib 40mg was given intravenously, and PCA with
sufentanil 1ug/ml was started immediately after surgery, suing a controlled infusion pump.
The pump was programmed to use a loading dose of 2ml, background infusion at 2m/h, PCA dose
of 1ml, lockout time of 10min, and maximal dose of 12ml with 1 h period.
VAS(static), VAS(dynamic), Ramssay, HR, NBP, SpO2, PCA pressing frequency, PCA comsumption
were recorded 6h, 12h, 24h, 48h after surgery. Side effects such as nausea, vomiting,
respiratory depression; pruritus; abdominal distention; urinary retention and dizziness were
also recorded, and corresponding treatment were given.
EDTA anti-coagulated blood was collected from a central venous catheter during the
operation. Genomic DNA was extracted from the blood samples, and characteristics and degree
of DNA methylation of the gene OPRM1 were analysed.
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