Epigenetics Clinical Trial
Official title:
BCG-induced Epigenetic Modifications in the NEXT Generation
Non-specific protective effects resulting from the BCG vaccine appear to be paternally inheritable. Since the BCG vaccine is known to induce trained immunity, epigenetics might explain the fathers' contribution to the immune profile of their offspring. Epigenetic inheritance in mice has recently been demonstrated, but is not established in humans yet. By studying the DNA methylation profile of sperm cells after BCG vaccination, we aim to gain insight into the possibility of epigenetic inheritance in human males.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02244684 -
Effects of Maternal Folate and Folic Acid Supplementation on DNA Methylation in the Newborn Infant
|
N/A | |
| Recruiting |
NCT03402139 -
Early Childhood Obesity Programming by Intrauterine Growth Restriction
|
||
| Not yet recruiting |
NCT05779904 -
Methylation, mIcrobiome, NUtritional sTatus, and dEvelopment of Stunted Children
|
||
| Recruiting |
NCT05791149 -
Epigenetic Biomarkers in the Saliva for the Diagnosis of Squamous Cells Carcinoma of the Oral Cavity
|
N/A | |
| Completed |
NCT03371446 -
DNA Methylation Profile of the SOCS-1 Gene Promoter in Smokers Patients With Chronic Periodontitis.
|
N/A | |
| Completed |
NCT02191683 -
Foetal Exposure and Epidemiological Transition: Role of Anaemia in Early Life for Non-communicable Diseases Later
|
||
| Recruiting |
NCT05253924 -
Biological Underpinnings of Socio-emotional Regulation in Preterm Infants and Healthy Controls
|
||
| Completed |
NCT03647449 -
Examining the Effects of Juice Fasting
|
N/A | |
| Recruiting |
NCT04804280 -
Epigenetics and Protective Factors in the Preterm Infant
|
||
| Recruiting |
NCT03135795 -
The Epigenetic Modification in OPRM1 on Postoperative Analgesia and Side Effect Induced by Sufentanil
|
Phase 4 | |
| Recruiting |
NCT03742011 -
Offspring Born to Mothers With Polycystic Ovary Syndrome in Guangzhou Cohort Study
|
||
| Suspended |
NCT04220658 -
Biomarker Study to Evaluate Correlations Between Epigenetic Aging and NAD+ Levels in Healthy Volunteers
|
||
| Active, not recruiting |
NCT05892211 -
LINE-1 and Alu Methylation Levels Among Middle Aged Women With Low Cardiovascular Risk Profile in Respect of Menopausal Hot Flashes
|
||
| Recruiting |
NCT05004090 -
Emotional Regulation in Children With ND: the Role of Genomic Variation, Proteomic Patterns, and Early Experience
|
||
| Completed |
NCT04608448 -
Topical-RAPA Use in Inflammation Reversal and Re-setting the Epigenetic Clock
|
Early Phase 1 |