Clinical Trials Logo

Clinical Trial Details — Status: Not yet recruiting

Administrative data

NCT number NCT06408402
Other study ID # APHP230878
Secondary ID HGT/MFI/AR245071
Status Not yet recruiting
Phase
First received
Last updated
Start date May 1, 2024
Est. completion date May 1, 2028

Study information

Verified date April 2024
Source Assistance Publique - Hôpitaux de Paris
Contact Alexandre Buffet, MD, PhD
Phone 33-1-56093879
Email alexandre.buffet@aphp.fr
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The primary objective of the PGL.EXPO-2 study is to test the hypothesis that exposure (occupational, environmental and/or domestic) to succinate dehydrogenase inhibitors (SDHi) could contribute to tumor emergence in subjects carrying a germline mutation in one of the SDHx genes.The primary endpoint will be the proportion of subjects (cases or controls) exposed to SDHi and the association with paraganglioma risk. In addition, a blood sample (10 ml on EDTA) will be proposed to the participants to the study


Description:

Patients will be selected from subjects with a mutation in one of the SDHx genes. The cases will have developed a tumor, while the controls will be tumor-free. Controls will be matched to the cases according to age and type of gene affected. Past exposures will be sought through a telephone questionnaire. In addition, a blood sample (10 ml on EDTA) will be proposed to the participants to the study


Read more »

Study Design


Related Conditions & MeSH terms


See more »

Sponsors (4)

Lead Sponsor Collaborator
Assistance Publique - Hôpitaux de Paris ANSES, Centre Leon Berard, Institut National de la Santé Et de la Recherche Médicale, France

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary Impact of SDHi exposure in paraganglioma occurence Association between exposures and tumor occurrence measure with Odd ratio 36 months
Secondary Spatial distribution of cases Spatial distribution of tumor incidence 48 months
Secondary Incidence rate in France of pathologies linked to SDHx gene mutations Incidence rate in France of pathologies linked to SDHx gene mutations 48 months
See also
  Status Clinical Trial Phase
Active, not recruiting NCT05541653 - The IGNITE Study on Concentrated Investment in Black Neighborhoods N/A
Completed NCT04028791 - Sickle Cell Trait and Exercise, Effect of Hot Environment N/A
Not yet recruiting NCT05105386 - The Impact of Synergies of Indoor Air Pollutants on Childhood Health and Wellbeing
Completed NCT05507944 - FeNO Hairdressers Pilot
Completed NCT04146025 - Nurtured in Nature N/A
Recruiting NCT05179993 - Detection of Microplastics in Human Granulosa Cells and in the Follicular Fluid of Women Undergoing ICSI Treatment
Completed NCT03444922 - Effects of BPA on Insulin and Glucose Responses N/A
Recruiting NCT03319927 - Reducing Pesticide Exposures in Child Care Centers N/A
Recruiting NCT05500690 - Understanding Effects of Folic Acid on the Methylosome and Transcriptome of Women With Spina Bifida Affected Pregnancies N/A
Recruiting NCT05394363 - Generation Victoria Cohort 2020s: A Statewide Longitudinal Cohort Study of Victorian Children and Their Parents
Completed NCT00021658 - Effects of Pesticide Exposure on Neurodevelopment/Growth/Respiratory Health N/A
Not yet recruiting NCT05315388 - Effects of "Vitamin N" Nature Immersion Therapy on Stress Levels in Health Care Workers in the City of Bogotá N/A
Recruiting NCT06107933 - Developmental Impacts of Microplastics Exposure in Early Life
Completed NCT03631667 - Ultralow Dose PAH Binary Mixture Study Early Phase 1
Completed NCT02540408 - Detection and Characterization of COPD in Dairy Farmers N/A
Completed NCT03440307 - Intervention to Reduce Bisphenol A Exposure in Women N/A
Completed NCT05160948 - Change in Knowledge After Receiving Personal Air Pollution Results
Recruiting NCT05865782 - Reconstructing Schoolyards With Greenery to Increase Schoolchildren's Physical Activity and Mitigate Climate Changes N/A
Completed NCT02707172 - Removal of Dermal Exposure to Phthalate Ester by Hand Washing N/A
Active, not recruiting NCT03215368 - The Ma'Anshan Birth Cohort (MABC)