Clinical Trials Logo
  1. Home
  2. Environmental Exposure
  3. NCT05500690

Understanding Effects of Folic Acid on the Methylosome and Transcriptome of Women With Spina Bifida Affected Pregnancies

Environmental Exposure Clinical Trial

Official title:
Understanding Effects of Folic Acid on the Methylosome and Transcriptome of Women With Spina Bifida Affected Pregnancies

Clinical Trial Summary

Folic acid is currently considered to be the standard of care for primary and secondary prevention of spina bifida, but the mechanisms underlying folic acid's benefits are unknown. One hypothesis is that folic acid changes DNA methylation and transcription of genes important in neural tube closure. In this study, the investigators will evaluate how DNA methylation of genes associated with neural tube closure changes after a short course of standard-of-care folic acid supplementation. In addition, the investigators will assess whether environmental arsenic exposure modifies the effects of folic acid on the methylosome.

Clinical Trial Description

The investigators will encourage women who have recently had a pregnancy affected by spina bifida to take daily folic acid supplements for three months. Folic acid supplementation is considered standard of care for primary and secondary prevention of spina bifida. The investigators will compare DNA methylation in blood and folate levels before and after folic acid use. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05500690
Study type Interventional
Source Boston Children's Hospital
Contact Maitreyi Mazumdar, MD, MPH
Phone 617-355-2918
Email maitreyi.mazumdarmdmph@childrens.harvard.edu
Status Recruiting
Phase N/A
Start date October 8, 2023
Completion date November 2025
View Details
See also
  Status Clinical Trial Phase
Active, not recruiting NCT05541653 - The IGNITE Study on Concentrated Investment in Black Neighborhoods N/A
Completed NCT04028791 - Sickle Cell Trait and Exercise, Effect of Hot Environment N/A
Not yet recruiting NCT05105386 - The Impact of Synergies of Indoor Air Pollutants on Childhood Health and Wellbeing
Completed NCT05507944 - FeNO Hairdressers Pilot
Completed NCT04146025 - Nurtured in Nature N/A
Recruiting NCT05179993 - Detection of Microplastics in Human Granulosa Cells and in the Follicular Fluid of Women Undergoing ICSI Treatment
Completed NCT03444922 - Effects of BPA on Insulin and Glucose Responses N/A
Recruiting NCT03319927 - Reducing Pesticide Exposures in Child Care Centers N/A
Recruiting NCT05394363 - Generation Victoria Cohort 2020s: A Statewide Longitudinal Cohort Study of Victorian Children and Their Parents
Completed NCT00021658 - Effects of Pesticide Exposure on Neurodevelopment/Growth/Respiratory Health N/A
Not yet recruiting NCT05315388 - Effects of "Vitamin N" Nature Immersion Therapy on Stress Levels in Health Care Workers in the City of Bogotá N/A
Recruiting NCT06107933 - Developmental Impacts of Microplastics Exposure in Early Life
Completed NCT03631667 - Ultralow Dose PAH Binary Mixture Study Early Phase 1
Completed NCT02540408 - Detection and Characterization of COPD in Dairy Farmers N/A
Completed NCT03440307 - Intervention to Reduce Bisphenol A Exposure in Women N/A
Completed NCT05160948 - Change in Knowledge After Receiving Personal Air Pollution Results
Not yet recruiting NCT05865782 - Reconstructing Schoolyards With Greenery to Increase Schoolchildren's Physical Activity and Mitigate Climate Changes N/A
Completed NCT02707172 - Removal of Dermal Exposure to Phthalate Ester by Hand Washing N/A
Active, not recruiting NCT03215368 - The Ma'Anshan Birth Cohort (MABC)
Recruiting NCT06083415 - Early Breast Growth in Girls Aged 6 to 8 Years in the Current Environmental Context N/A