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SDH Gene Mutation clinical trials

View clinical trials related to SDH Gene Mutation.

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NCT ID: NCT06408402 Not yet recruiting - Clinical trials for Environmental Exposure

Impact of Environmental Exposures on Tumor Risk in SDHx-mutation Carriers

PGLEXPO2
Start date: May 1, 2024
Phase:
Study type: Observational

The primary objective of the PGL.EXPO-2 study is to test the hypothesis that exposure (occupational, environmental and/or domestic) to succinate dehydrogenase inhibitors (SDHi) could contribute to tumor emergence in subjects carrying a germline mutation in one of the SDHx genes.The primary endpoint will be the proportion of subjects (cases or controls) exposed to SDHi and the association with paraganglioma risk. In addition, a blood sample (10 ml on EDTA) will be proposed to the participants to the study

NCT ID: NCT04481152 Not yet recruiting - Clinical trials for Genetic Predisposition

Impact of Environmental Exposures on Tumor Risk in Subjects at Risk of Hereditary SDHx Paraganglioma

PGL-EXPO-1
Start date: March 1, 2022
Phase:
Study type: Observational

The main objective of the pilot phase of PGLEXPO will be to assess the faisability and to precise methodology of a case-control study designed for testing the impact of environmental and professional exposures on the tumoral risk in SDHx-mutation carriers