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Impact of Environmental Exposures on Tumor Risk in SDHx-mutation Carriers — PGLEXPO2  

Environmental Exposure Clinical Trial

Official title:
Impact of Environmental Exposures on Tumor Risk in Subjects at Risk of Hereditary SDHx-related Paragangliomas - National Study

Clinical Trial Summary

The primary objective of the PGL.EXPO-2 study is to test the hypothesis that exposure (occupational, environmental and/or domestic) to succinate dehydrogenase inhibitors (SDHi) could contribute to tumor emergence in subjects carrying a germline mutation in one of the SDHx genes.The primary endpoint will be the proportion of subjects (cases or controls) exposed to SDHi and the association with paraganglioma risk. In addition, a blood sample (10 ml on EDTA) will be proposed to the participants to the study

Clinical Trial Description

Patients will be selected from subjects with a mutation in one of the SDHx genes. The cases will have developed a tumor, while the controls will be tumor-free. Controls will be matched to the cases according to age and type of gene affected. Past exposures will be sought through a telephone questionnaire. In addition, a blood sample (10 ml on EDTA) will be proposed to the participants to the study ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06408402
Study type Observational
Source Assistance Publique - Hôpitaux de Paris
Contact Alexandre Buffet, MD, PhD
Phone 33-1-56093879
Email alexandre.buffet@aphp.fr
Status Not yet recruiting
Phase
Start date May 1, 2024
Completion date May 1, 2028
View Details
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