The Effect of Contrast Agent on Endothelial Function in Healthy Men

Status Completed

Clinical Trial Summary

Contrast medium is essential for diagnosis of many diseases. However, recent studies showed that contrast agents can induce renal injury and is associated with poor long-term clinical outcome, especially in diabetes. To date, no data are available on the relationship between contrast medium and endothelial function. Endothelial dysfunction is known to precede atherosclerosis and is considered a risk marker for future development of cardiovascular disease. Therefore, we hypothesized that contrast agents may induce endothelial dysfunction in healthy men. In addition, we hypothesized that contrast induced endothelial dysfunction via free radicals. Thus, we also test alpha-lipoic acid whether or not protect endothelial dysfunction induced by contrast agents.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Health Services Research

Related Conditions & MeSH terms

Alpha-lipoic Acid
Apoptosis of Endothelial Progenitor Cell
Contrast Agent
Cytokines
Endothelial Function
Free Radical

Clinical Trial Details

NCT number	NCT01895699
Study type	Interventional
Source	Wuhan General Hospital of Guangzhou Military Command
Contact
Status	Completed
Phase	Phase 4
Start date	July 2013
Completion date	July 2015

View Details

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