Endothelial Dysfunction Clinical Trial
Official title:
Endothelial Dysfunction, Biomarkers, and Lung Function (MESA LUNG)
The purpose of MESA-Lung is to assess the role of endothelial dysfunction and genetic susceptibility in subclinical COPD.
Chronic obstructive pulmonary disease (COPD) is currently the fourth leading cause of death
in the United States, and morbidity and mortality from COPD continue to rise. Despite the
magnitude of the problem, therapeutic options are limited - particularly in comparison to
cardiovascular disease. Smoking cessation is essential to the treatment and prevention of
COPD. However, although smoking is the principal cause of COPD, only a minority of smokers
develops symptomatic COPD and many former smokers develop COPD years to decades after they
have stopped smoking. The only other medical intervention proven to reduce mortality from
COPD is supplemental oxygen therapy. There is therefore an urgent need for newer
understandings of the pathophysiology of COPD that might lead to the development of better
therapies for COPD.
MESA-Lung is ancillary of the ongoing Multi-Ethnic Study of Atherosclerosis (MESA).
MESA-lung will utilize the various existing measures of endothelial function that have been
already been collected in MESA (flow-mediated dilatation [FMD] and related biomarkers and
gene polymorphisms) to test the hypotheses that the endothelial dysfunction occurs in the
clinical COPD.
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Observational Model: Cohort, Time Perspective: Prospective
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