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Clinical Trial Summary

Cardioembolism is a postulated mechanism of an embolic stroke of undetermined source (ESUS). The investigators will measure endothelial glycocalyx, aortic elastic properties, oxidative stress, and their association with left ventricular (LV) and left atrial (LA) function in ESUS and age- and sex-adjusted healthy individuals.


Clinical Trial Description

The investigators aim to evaluate consecutive acute ischemic stroke (AIS) patients satisfying ESUS diagnostic criteria in a single tertiary care stroke center (University Hospital, Athens, Greece). Moreover, baseline characteristics and outcome measures for all AIS patients are going to be recorded and further be classified, according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) and ESUS criteria. Healthy volunteers (colleagues, friends, relatives and others) will be included in the control group.

In participants (patients and controls) the investigators plan to measure: a) perfused boundary region (PBR) of the sublingual arterial microvessels (range 5-25 micrometers), a marker inversely related with glycocalyx thickness, b) pulse wave velocity (PWV), central systolic blood pressure (cSBP) and augmentation index (AIx), c) LV Global Longitudinal strain (GLS), d) LA volume and strain using speckle-tracking strain imaging, e) Malondialdehyde (MDA), as an oxidative stress marker. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03609437
Study type Observational
Source University of Athens
Contact
Status Completed
Phase
Start date January 1, 2018
Completion date June 30, 2018

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