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Oral 6R-BH4 for the Treatment of Isolated Systolic Hypertension and Endothelial Dysfunction

Endothelial Dysfunction Clinical Trial

Official title:
Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation, Parallel Study of Oral 6R-BH4 in Subjects With Isolated Systolic Hypertension and Endothelial Dysfunction

Clinical Trial Summary

This study is designed to assess the safety and efficacy of twice-daily oral dosing of 6R-BH4 to improve endothelial function, reduce systolic blood pressure and reduce arterial stiffness.

Clinical Trial Description

By comparing values measured at different timepoints, the study is expected to provide insight regarding the ability of 6R-BH4, administered along with their currently prescribed antihypertension medications, to improve endothelial function, reduce SBP, and reduce arterial stiffness in patients with ISH and endothelial dysfunction ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00802893
Study type Interventional
Source Johns Hopkins University
Contact
Status Terminated
Phase Phase 2
Start date December 2008
Completion date May 2009
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