Clinical Trials Logo
  1. Home
  2. End Stage Liver Disease
  3. NCT01171742

Effect of Intermittent Hepatic Inflow Occlusion During Donor Hepatectomy In Living Donor Liver Transplantation

End Stage Liver Disease Clinical Trial

Official title:
Effect of Intermittent Hepatic Inflow Occlusion During Donor Hepatectomy In Adult Living Donor Liver Transplantation Using Right Hemiliver Grafts

Clinical Trial Summary

Intermittent hepatic inflow occlusion (IHIO), also called Pringle maneuver, is a safe and effective procedure for major hepatectomy in patients with liver disease. In addition, ischemic preconditioning with IHIO has been reported to have protective effects in patients undergoing liver resection. The role of IHIO, however, has not been fully elucidated in donors and recipients during living donor liver transplantation.

Clinical Trial Description

Intermittent hepatic inflow occlusion (IHIO) by clamping of the portal triad, also called Pringle maneuver, is a safe and effective procedure in major hepatectomy in patients with liver disease. IHIO minimizes blood loss and operation time during liver resection. In addition, ischemic preconditioning with IHIO has been reported to have protective effects in patients undergoing liver resection. In the setting of living donor liver transplantation (LDLT), one of the most important concerns is liver donor safety. Several studies have shown the safety of IHIO in donors for liver transplantation (LT). However, the effect of preconditioning with IHIO during donor hepatectomy on LDLT recipients remains unclear. Several small series have assessed the effects on recipients of ischemic preconditioning during whole liver transplantation from deceased donors. The role of IHIO, however, has not been fully elucidated in liver donors and recipients during LDLT. In this randomized, prospective study, we'll evaluate the efficacy of IHIO in the recipients and donors. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01171742
Study type Interventional
Source Samsung Medical Center
Contact
Status Active, not recruiting
Phase Phase 3
Start date July 2008
Completion date August 2010
View Details
See also
  Status Clinical Trial Phase
Completed NCT03557086 - A Randomized Controlled Trial of an Advanced Care Planning Video Decision Support Tool for Patients With End-Stage Liver Disease N/A
Completed NCT04604860 - Use of EL-FIT App to Promote Physical Activity N/A
Completed NCT01933789 - Improving Communication About Serious Illness N/A
Recruiting NCT01728688 - Safety and Efficacy of Human Autologous Peripheral Blood Stem Cells for Treatment of HBV-related Liver Cirrhosis Phase 1/Phase 2
Recruiting NCT01728727 - Safety and Efficacy of Human Umbilical Cord Derived Mesenchymal Stem Cells for Treatment of HBV-related Liver Cirrhosis Phase 1/Phase 2
Recruiting NCT01724697 - Safety and Efficacy of Human Bone Marrow Stem Cells for Treatment of HBV-related Liver Cirrhosis Phase 1/Phase 2
Not yet recruiting NCT01412593 - Intra-hepatic Artery Bone Marrow Derived Stem Cells Infusion for the Treatment of Advanced Liver Cirrhosis Phase 1/Phase 2
Completed NCT00374582 - End Stage Liver Disease and Body Composition Assessment: Utilizing Bioelectric Impedance Analysis (BIA) N/A
Completed NCT00249652 - Transplant and Addiction Project (TAP) - 1 Phase 1/Phase 2
Recruiting NCT05998330 - LiverPAL: A Trial of Inpatient Palliative Care for Patients With Advanced Liver Disease N/A
Completed NCT04546048 - The Early Strength Training Program in Post-transplant Liver Cases N/A
Active, not recruiting NCT03580629 - Pilot Study of the Liver Live Donor Champion Program N/A
Recruiting NCT04037995 - Real World Study of End-stage Liver Disease in China
Recruiting NCT03870568 - Functional Assessment in Liver Transplantation
Recruiting NCT03633812 - Effect of Preoperative Beta Blocker Use Postoperative Renal Function in the Patients Undergoing Liver Transplantation
Active, not recruiting NCT02889094 - French HIV-HBV Cohort
Completed NCT02444273 - The Feasibility of a Prehabilitation Program in the Liver Transplant Population at Barnes-Jewish Hospital N/A
Recruiting NCT01711073 - Mobilization of Stem Cells With G-CSF and Mozobil in Patients With End Stage Liver Disease Phase 1
Not yet recruiting NCT06069050 - SALT in Adolescents With End-stage Liver Disease N/A
Recruiting NCT03228290 - Functional Assessment in Liver Transplantation