Emphysema or COPD Clinical Trial
Official title:
Measuring Collateral Ventilation Using Chartis® to Select Patients With Severe Emphysema for Endobronchial Valve Treatment: Conscious Sedation Versus General Anesthesia
Rationale: The Chartis® ( Pulmonx, CA, USA) measurement system is a tool to assess interlobar
collateral ventilation during bronchoscopy. Assessing collateral ventilation is important
when you intend to treat a patient with endobronchial valves. Chartis measurement of
collateral ventilation can be performed under both conscious sedation as well as general
anesthesia. There is no consensus on what is the preferred method of anesthesia for Chartis
measurements in the literature.
Objective: In this project we want to investigate whether there is a difference in Chartis
measurement outcomes between these two methods of anesthesia: conscious sedation and general
anesthesia.
Study design: This study will be a single center observational study
Study population: The study population exists of patients with severe emphysema who undergo
collateral ventilation assessment before bronchoscopic lung volume reduction treatment with
one-way endobronchial valves.
Intervention: All patients will undergo two subsequent Chartis measurements. The first
measurement will be performed with the patient undergoing conscious sedation and the second
measurement with the patient under general anesthesia.
Main study parameters/endpoints: Our primary outcome measure is the failure rate of the
Chartis collateral ventilation measurement under general anesthesia versus conscious
sedation.
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