Dyspnea Clinical Trial
Official title:
Study of Cytokine Response During Exercise Dyspnea in Patients With Chronic Obstructive Pulmonary Disease (COPD). Effect of Body Composition
Dyspnea, more commonly known as breathlessness, is a symptom found in the majority of patients with chronic obstructive pulmonary disease (COPD), with a major impact on quality of life and mortality. COPD is a chronic inflammatory disease of the bronchi, affecting 8% of the French population (more than 3 million people). By 2030, it will be the third leading cause of death worldwide. Effective management of dyspnea in these patients is a priority. In patients with severe COPD, physical exertion increases the workload of breathing, leading to dyspnea. At the same time, the respiratory muscles and fatty cells release cytokines, myokines and adipokines - a group of proteins involved in the inflammatory response. In addition, 15% of COPD patients suffer from sarcopenia (loss of muscle mass and strength) which increases respiratory effort and dyspnea. Our research project aims to study the effect of dyspnea relief in COPD patients on cytokine, myokine and adipokine levels, taking into account the presence of sarcopenia. Indeed, it is possible to alleviate the workload of the respiratory muscles during exercise by means of respiratory assistance. The ultimate goal is a better understanding of dyspnea mechanisms, to enable the development of cytokine-targeted therapies and improve quality of life and survival in these patients.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT04688905 -
Diagnosing Heart Failure With Preserved Ejection Fraction in Patients With Unexplained Dyspnea (Diagnose-HFpEF)
|
||
| Completed |
NCT03679312 -
The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in COPD
|
Phase 1/Phase 2 | |
| Recruiting |
NCT04868357 -
Hypnosis for the Management of Anxiety and Breathlessness During a Pulmonary Rehabilitation Program
|
N/A | |
| Active, not recruiting |
NCT03604822 -
Music Therapy Protocol to Support Bulbar and Respiratory Functions in ALS
|
N/A | |
| Completed |
NCT03626519 -
Effects of Menthol on Dyspnoea in COPD Patients
|
N/A | |
| Completed |
NCT02638649 -
Prehospital Use of Ultrasound in Undifferentiated Shortness of Breath
|
||
| Terminated |
NCT02269761 -
Chest Ultrasound of ER Patients With Cough or SOB
|
||
| Completed |
NCT02538770 -
Rapid Viral Diagnostics in Adults to Reduce Antimicrobial Consumption and Duration of Hospitalization
|
N/A | |
| Completed |
NCT02248831 -
Evaluation of Cardiopulmonary Diseases by Ultrasound
|
N/A | |
| Recruiting |
NCT01655199 -
Sensitivity of the Step Test to Detect Improvement in Dyspnea Following Bronchodilation in Patients With Chronic Obstructive Pulmonary Disease
|
N/A | |
| Active, not recruiting |
NCT01440764 -
Aerosol Inhalation Treatment for Dyspnea
|
Phase 1/Phase 2 | |
| Completed |
NCT01577407 -
Non Opioid Treatment for Experimental Dyspnea
|
Phase 3 | |
| Completed |
NCT01193998 -
Impact of Validated Diagnostic Prediction Model of Acute Heart Failure in the Emergency Department
|
N/A | |
| Recruiting |
NCT04327882 -
Point-of-care Ultrasound Interest in Dyspneic Emergency Department Patients: an Observational Bicentric Study
|
||
| Completed |
NCT05029986 -
Preventing Dyspnea During Speech in Older Speakers
|
N/A | |
| Not yet recruiting |
NCT04181359 -
The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in Interstitial Lung Disease.
|
Phase 1/Phase 2 | |
| Recruiting |
NCT04615065 -
Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine
|
||
| Completed |
NCT04305639 -
The Reliability and Validity of Turkish Version of ''The Dyspnea-ALS-Scale (DALS-15)"
|
||
| Completed |
NCT04370990 -
Automated Oxygen Administration -Rethinking Interventions Alleviating Dyspnea in Patients With COPD
|
N/A | |
| Completed |
NCT04375917 -
Is Reduced Hypoxia Through a Robot Intervention, Associated With Sensory and Emotional Descriptions of Dyspnea, Anxiety, Depression, Symptom Burden and Anxiolytics
|
N/A |