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Dysphagia, Esophageal clinical trials

View clinical trials related to Dysphagia, Esophageal.

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NCT ID: NCT06398405 Recruiting - Esophageal Cancer Clinical Trials

A Phase II Clinical Study of Epigallocatechin-3-gallate in Patients With Esophageal Squamous Cancer

Start date: April 22, 2024
Phase: Phase 2
Study type: Interventional

The investigators conduct this phase II study to evaluate safety and effectiveness of EGCG in patients with dysphagia. Swallowing-related dysphagia and pain scores were recorded using the numerical rating scale (NRS) daily . Barium meal radiography was utilized to measure the luminal size and the length of the lesion area both before and after a week of EGCG treatment. The scales are translated into Chinese and guides in Chinese are developed instructing how to use the scales and perform the assessments.

NCT ID: NCT06196606 Recruiting - Clinical trials for Dysphagia, Oropharyngeal

Effect of Botulinum Toxin Injection Into Upper Esophageal Sphincter in Patients With Medullary Infarction

Start date: November 11, 2022
Phase: N/A
Study type: Interventional

Dysphagia is an important complication in patients with medullary infarction, the incidence rate is 57%-69%. Compared with other brain infarctions, the medulla oblongata involves multiple swallowing-related nerve nuclei, and the possibility of brain remodeling after injury is small. Dysphagia has become a prominent clinical problem in patients with medullary infarction, which can lead to malnutrition, decrease the quality of life of patients and affect the prognosis of the disease. Solving this clinical problem is particularly important for patients with medullary infarction. The incidence of UES opening disorder in patients with medullary infarction is as high as 80%, and the clinical problem of UES opening disorder is enthusiastically studied at home and abroad. At present, the intervention measures include balloon dilatation, surgical incision and botulinum toxin injection. Balloon dilatation is easy to cause mucosal edema and damage, and cricopharyngeal myotomy often has complications such as local infection, massive hemorrhage and local nerve injury. There is no significant difference between the success rate of UES botulinum toxin injection and surgical incision. Among the above measures, UES botulinum toxin injection has a good clinical application prospect, but the drug dosage and injection method are still not unified in clinic. In particular, how to accurately locate has become a hot topic in current research. On this basis, this study uses ultrasound combined with balloon localization to inject UES botulinum toxin and make clinical observation.

NCT ID: NCT06173388 Completed - Clinical trials for Dysphagia, Esophageal

Exercise Training for Cervicogenic Dysphagia

Start date: February 1, 2022
Phase: N/A
Study type: Interventional

Background: Cervicogenic dysphagia is a swallowing difficulty caused by cervical problems that negatively impact pulmonary health, and quality of life and may increase the risk of mortality. Study design: Randomized Controlled Study Purpose: The purpose was to explore the effect of a structured exercise training program composed of cervical stretching, strengthening and stabilizing exercises on the swallowing function, craniovertebral angle, and pulmonary function in patient with cervicogenic dysphagia. Methods: 32 patients (age 35-50 years) with cervicogenic dysphagia were randomly allocated into study group (n=17) and control group (n=15). The craniovertebral angle (CVA), the swallowing function (using the swallow-difficulty questionnaire "SDQ") and the pulmonary function (including the forced vital capacity "FVC" and forced expiratory volume in one second "FEV1") were evaluated pre-study and post-study. All participants received three sessions/week for 8-weeks. The study group received the structured exercise program, in addition to the swallow resistance exercise (SRE), while the control group received the swallow resistance exercise only.

NCT ID: NCT05708885 Recruiting - Clinical trials for Dysphagia, Esophageal

Striated Esophageal Motor Function Modulation in Health and Disease

Start date: September 13, 2022
Phase: N/A
Study type: Interventional

The investigators hypothesize that striated esophagus deglutitive motor function is modulated by pharyngeal phase swallowing biomechanics.

NCT ID: NCT05629325 Recruiting - Clinical trials for Dysphagia, Esophageal

Buspirone for Weak or Absent Esophageal Peristalsis

Start date: July 6, 2021
Phase: Phase 4
Study type: Interventional

This is a randomized, double-blind, placebo-controlled, cross-over clinical trial of buspirone in patients with complaints of dysphagia due to poor esophageal motility. The goal of this clinical trial is to study the effect of buspirone on esophageal motility by performing high resolution impedance manometry (HRiM).

NCT ID: NCT05082948 Completed - Esophageal Cancer Clinical Trials

Migration Rates of Sutured vs Non-sutured Esophageal Stent Placement

Start date: July 20, 2021
Phase: N/A
Study type: Interventional

No standard approach currently exists for endoscopic esophageal stent placement, and both sutured and un-sutured techniques are employed for esophageal stent placement currently. The primary purpose of this study is to find out if suture fixation of esophageal stents is superior to non-suture fixated stent placement. Consecutive patients who are scheduled for esophageal stent placement will be identified as potential study participants by study personnel and will be approached on the day of the procedure. Informed consent will be obtained and patients will be randomized into suture fixation and non-suture fixation groups. Patients in the suture fixation group will have their esophageal stent secured in location with two endoscopic sutures. Those in the non-suture fixation group will have no sutures placed. Main study outcome is stent migration, and rates of stent migration will be compared in the two groups.

NCT ID: NCT05069493 Completed - Quality of Life Clinical Trials

Long-term Follow-up After Hiatal Hernia Repair by Tension-free Mesh Closure or Simple Suturing

Start date: September 15, 2021
Phase:
Study type: Observational

10 years of follow-up after surgery for hiatal hernia by tension-free mesh closure or simple suturing.

NCT ID: NCT04741581 Completed - Clinical trials for Dysphagia, Esophageal

ThickenUp® Gel Express for Patients With Dysphagia

HYDRA-01
Start date: May 11, 2021
Phase: N/A
Study type: Interventional

Evaluation of swallowing function and hydration following consumption of ThickenUp® Gel Express in patients with dysphagia.

NCT ID: NCT04565587 Recruiting - Dysphagia Clinical Trials

Dose-response Effect of the Thickener Tsururinko Quickly

58/19
Start date: August 5, 2020
Phase: N/A
Study type: Interventional

Thickening fluids are a valid therapeutic strategy to improve safe swallowing in OD. The aim of this study is to assess the percentage of safe swallowing at different viscosity levels thickened with Tsururinko Quickly. This study is designed to assess the therapeutic effect on safety and efficacy of swallow of Tsururinko Quickly for the levels of viscosity 100, 200, 400, 800, 1600mPa·s against thin liquid and between all the viscosity levels in older patients with Oropharyngeal Dysphagia (OD) by performing a Videofluoroscopy when swallowing. As all patients will start with thin liquid, each patient will be its own control. To analyze the effect of the salivary amylase on the thickener, participants will be asked to maintain two boluses (200 and 800mPa·s) prepared jut with mineral water in the oral cavity for 30seconds. After that period, boluses will be analyzed by a viscometer and compared to those without oral incubation.

NCT ID: NCT04503785 Recruiting - Clinical trials for Dysphagia, Esophageal

Esophageal Impedance and Manometry Measurements and Dysphagia Symptom Scoring

Start date: January 17, 2017
Phase:
Study type: Observational [Patient Registry]

Comparison of manometry measurements and EndoFlip Balloon measurements in patients with dysphagia and a known esophageal diagnosis