Pemafibrate to Reduce Cardiovascular OutcoMes by Reducing Triglycerides IN patiENts With diabeTes (PROMINENT)

Dyslipidemia Clinical Trial

— PROMINENT  

Official title:

Pemafibrate to Reduce Cardiovascular OutcoMes by Reducing Triglycerides IN patiENts With diabeTes (PROMINENT)

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT03071692
• Other study ID #: K-877-302
• Status: Terminated
• Phase: Phase 3
• Start date: March 23, 2017
• Est. completion date: July 27, 2022

Study information

• Verified date: July 2023
• Source: Kowa Research Institute, Inc.
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The primary objective of the study is to determine whether pemafibrate administered twice daily will delay the time to first occurrence of any component of the clinical composite endpoint of: - nonfatal Myocardial Infarction (MI) - nonfatal ischemic stroke - coronary revascularization; or - Cardio Vascular (CV) death.

Description:

A multi-regional clinical trial with participating sites in the following countries. India is being conducted under a previous protocol version due to regulatory requirements. - Argentina - Brazil - Bulgaria - Canada - Colombia - Czech Republic - Denmark - France - Germany - Hungary - India - Israel - Japan - Mexico - Netherlands - Poland - Romania - Russian Federation - Slovakia - South Africa - Spain - Ukraine - United Kingdom - United States

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 10544
• Est. completion date: July 27, 2022
• Est. primary completion date: July 27, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Fasting TG = 200 mg/dL (2.26 mmol/L) and < 500 mg/dL (5.65 mmol/L) at Visit 1 (Screening/Enrollment Visit) or Visit 1.1 (Retest)

2. HDL-C = 40 mg/dL (1.03 mmol/L) at Visit 1 (Screening/Enrollment Visit) or Visit 1.1 (Retest)

3. Type 2 diabetes of longer than 12 weeks duration documented in medical records, for example: local laboratory evidence through medical record review of elevated HbA1c (= 6.5% [48 mmol/mol]), elevated plasma glucose (fasting = 126 mg/dL [7.0 mmol/L], 2-hour = 200 mg/dL [11.1 mmol/L] during oral glucose tolerance testing, or random value = 200 mg/dL with classic symptoms, or currently taking medication for treatment of diabetes; AND either

1. Age = 50 years if male or = 55 years if female (primary prevention cohort); OR

2. Age = 18 years and established systemic atherosclerosis (secondary prevention

cohort), defined as any 1 of the following:

• i. Prior MI or ischemic (non-hemorrhagic) stroke
• ii. Coronary angiographic lesion of = 60% stenosis in a major epicardial vessel or = 50% left main stenosis
• iii. Asymptomatic carotid disease with = 70% carotid artery stenosis
• iv. Symptomatic carotid disease with = 50% carotid artery stenosis
• v. Symptomatic lower extremity PAD (ie, intermittent claudication, rest pain, lower extremity ischemic ulceration, or major amputation with either ankle-brachial index = 0.9 or other diagnostic testing [eg, toe-brachial index, angiogram, or other imaging study])
• vi. Prior arterial revascularization procedure (including coronary, carotid, or peripheral angioplasty/stenting, bypass, or atherectomy/endarterectomy)

Exclusion Criteria:

1. Current or planned use of fibrates or agents with PPAR-a agonist activity (eg, saroglitazar) within 6 weeks (42 days) of Visit 1 (Screening/Enrollment Visit). Note: PPAR-? agonists (eg, glizatones such as pioglitazone and rosiglitazone) are allowed

2. Known sensitivity to PPAR-a agonists or tablet excipients

3. Initiation of, or change in, current TG-lowering therapy within 12 weeks of Visit 1 (if applicable). Note: TG-lowering therapy is defined as niacin > 100 mg/day or dietary supplements or prescription omega-3 fatty acids > 1 g/day

4. Type 1 diabetes mellitus

Related Conditions & MeSH terms

• Diabetes Mellitus
• Dyslipidemia
• Dyslipidemias
• Type2 Diabetes

Intervention

Drug:
• K-877
0.2mg tablet
• Placebo
K-877 matching placebo tablet

Locations

Country	Name	City	State
Argentina	Hospital Interzonal General de Agudos Dr Jose Penna	Bahia Blanca	Buenos Aires
Argentina	Hospital Italiano Regional del Sur	Bahia Blanca	Buenos Aires
Argentina	Hospital Sirio Libanes	Caba	Ciudad Autonoma Buenos Aires
Argentina	CCBR - Buenos Aires - AR	Ciudad Autonoma Buenos Aires
Argentina	CEDIC Centro de Investigaciones Clinicas	Ciudad Autonoma Buenos Aires
Argentina	Centro Medico Dra Laura Maffei Investigacion Clinica Aplicada	Ciudad Autonoma Buenos Aires
Argentina	CIPREC	Ciudad Autonoma Buenos Aires
Argentina	Consultorio Dr. Litvak Bruno	Ciudad Autonoma Buenos Aires
Argentina	Fundacion Favaloro	Ciudad Autonoma Buenos Aires
Argentina	Hospital Italiano	Ciudad Autonoma Buenos Aires	Buenos Aires
Argentina	Instituto Cardiovascular Buenos Aires	Ciudad Autonoma Buenos Aires
Argentina	Investigaciones Medicas IMOBA S.R.L	Ciudad Autonoma Buenos Aires
Argentina	Sanatorio Güemes	Ciudad Autonoma de Bs. As.	Ciudad Autonoma Buenos Aires
Argentina	Centro Medico Viamonte SRL	Ciudad Autonoma de Buenos Aires	Ciudad Autonoma Buenos Aires
Argentina	Clinica del Prado	Cordoba
Argentina	Hospital Privado Centro Medico de Cordoba S.A	Cordoba
Argentina	Inst. Privado de Inv. Clinicas de Cordoba	Cordoba
Argentina	Instituto Medico DAMIC	Cordoba
Argentina	Instituto de Cardiologia de Corrientes	Corrientes
Argentina	CICLO	La Plata	Buenos Aires
Argentina	Centro de Investigaciones Medicas Mar del Plata	Mar del Plata	Buenos Aires
Argentina	Instituto de Investigaciones Clinicas	Mar del Plata	Buenos Aires
Argentina	Prevencion Cardiovascular Salta	Salta
Argentina	Axismed S.R.L.- Clínica Mayo	San Miguel de Tucuman	Tucuman
Argentina	Instituto Clinico Metabolico	San Nicolas	Buenos Aires
Argentina	Instituto de Investigaciones Clinicas San Nicolas	San Nicolas	Buenos Aires
Argentina	Centro Medico Luquez	San Vicente	Cordoba
Argentina	Clinica Olivos	Vicente Lopez	Buenos Aires
Argentina	CEMEDIC - Centro de Especialidades Medicas	Villa Luro	Ciudad Autonoma Buenos Aires
Brazil	HUJBB-UFPA - Hospital Universitário João de Barros Barreto - Universidade Federal do Pará	Belém	Pará
Brazil	CARDRESEARCH - Cardiologia Assistencial	Belo Horizonte	Minas Gerais
Brazil	Hospital Felício Rocho	Belo Horizonte	Minas Gerais
Brazil	Maestri e Kormann Consultoria Medico Científica LTDA	Blumenau	Santa Catarina
Brazil	CECAP - Centro de Cardiologia Clínica	Brasília	Distrito Federal
Brazil	Clínica de Endocrinologia e Metabologia Ltda.	Brasília	Distrito Federal
Brazil	Hospital do Coração do Brasil	Brasília	Distrito Federal
Brazil	Hospital Universitário de Brasília	Brasília	Distrito Federal
Brazil	L2IP - Instituto de Pesquisas Clínicas Ltda.	Brasília	Distrito Federal
Brazil	Sociedade Hospitalar Angelina Caron	Campina Grande do Sul	Paraná
Brazil	IPCC - Instituto de Pesquisa Clínica de Campinas	Campinas	Sao Paulo
Brazil	Loema - Instituto de Pesquisa Clínica	Campinas	Sao Paulo
Brazil	Hospital Universitário	Canoas	Rio Grande Do Sul
Brazil	Cline Research Center (Leite PS Consultoria Medica LTDA)	Curitiba	Paraná
Brazil	Núcleo de Pesquisa Clínica S/S	Curitiba	Paraná
Brazil	CARDIOINTERV Centro de Pesquisa S/S	Goiânia	Goiás
Brazil	HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás	Goiânia	Goiás
Brazil	Via Médica	Goiânia	Goiás
Brazil	Paraná Medical Research Center	Maringá	Paraná
Brazil	Eurolatino Natal Pesquisas Médicas Ltda.	Natal	Rio Grande Do Norte
Brazil	Hospital São Vicente de Paulo	Passo Fundo	Rio Grande Do Sul
Brazil	Santa Casa de Misericórdia de Pelotas	Pelotas	Rio Grande Do Sul
Brazil	Centro de Pesquisa Clínica Maimônides - Maimônides Day Hospital	Porto Alegre	Rio Grande Do Sul
Brazil	Centro de Pesquisas em Diabetes Ltda.	Porto Alegre	Rio Grande Do Sul
Brazil	Hospital de Clínicas de Porto Alegre	Porto Alegre	Rio Grande Do Sul
Brazil	Santa Casa de Misericórdia de Porto Alegre	Porto Alegre	Rio Grande Do Sul
Brazil	CCBR Brasil Centro de Pesquisas e Análises Clínicas Ltda.	Rio de Janeiro	Rio Do Janeiro
Brazil	Centro de Pesquisa Médica Santa Maria Ltda.	Santa Maria	Rio Grande Do Sul
Brazil	CEMEC - Centro Multidisciplinar de Estudos Clínicos	São Bernardo do Campo	Sao Paulo
Brazil	Fundação Faculdade Regional de Medicina de São José do Rio Preto	São José do Rio Preto	Sao Paulo
Brazil	ISPEM - Instituto São José dos Campos em Pesquisas Médicas	São José dos Campos	Sao Paulo
Brazil	CEPIC - Centro Paulista de Investigação Clínica e Serviços Médicos	São Paulo	Sao Paulo
Brazil	Clínica Paulista de Doenças Cardiovasculares Ltda.	São Paulo	Sao Paulo
Brazil	CPCLIN - Centro de Pesquisas Clínicas Ltda.	São Paulo	Sao Paulo
Brazil	CPQuali Pesquisa Clínica Ltda.	São Paulo	Sao Paulo
Brazil	Dr. Consulta	São Paulo	Sao Paulo
Brazil	Hospital das Clínicas da Faculdade de Medicina da USP	São Paulo	Sao Paulo
Brazil	Incor - Instituto do Coração - HCFMUSP	São Paulo	Sao Paulo
Brazil	IMC - Instituto de Moléstias Cardiovasculares Tatuí	Tatuí	Sao Paulo
Brazil	Santa Casa de Votuporanga	Votuporanga	Sao Paulo
Bulgaria	MHAT 'Puls' AD	Blagoevgrad
Bulgaria	MHAT - Blagoevgrad, EOOD	Blagoevgrad
Bulgaria	MHAT "Yuliya Vrevska - Byala", EOOD	Byala
Bulgaria	MHAT-Haskovo, AD	Haskovo
Bulgaria	MHAT "Higia", AD - Pazardzhik	Pazardzhik
Bulgaria	MHAT - Pazardzhik AD	Pazardzhik
Bulgaria	MHAT "Sv. Pantaleymon - Pleven", OOD	Pleven
Bulgaria	SHATC Pleven EAD	Pleven
Bulgaria	UMHAT 'Dr. Georgi Stranski', EAD	Pleven
Bulgaria	UMHAT "Kaspela", EOOD	Plovdiv
Bulgaria	UMHAT "Sv. Georgi", EAD	Plovdiv
Bulgaria	MC Rusemed ltd.	Ruse
Bulgaria	Acibadem City Clinic Tokuda Hospital Ead	Sofia
Bulgaria	DCC "Alexandrovska", EOOD	Sofia
Bulgaria	Diagnostic Consultation Center CONVEX EOOD	Sofia
Bulgaria	Diagnostic Consultative Center II - Sofia OOD	Sofia
Bulgaria	Fifth MHAT - Sofia EAD	Sofia
Bulgaria	Fourth MHAT - Sofia EAD	Sofia
Bulgaria	MC "Synexus - Sofia", EOOD	Sofia
Bulgaria	MC Start - d-r Todor Dimitrov EOOD	Sofia
Bulgaria	Medical Center Kalimat	Sofia
Bulgaria	MHAT "Lyulin", EAD	Sofia
Bulgaria	MHAT - "National Heart Hospital" EAD	Sofia
Bulgaria	NMTH "Tsar Boris III"	Sofia
Bulgaria	UMHAT "Alexandrovska" EAD	Sofia
Bulgaria	UMHAT "SofiaMed", OOD	Sofia
Bulgaria	UMHAT 'Sveta Anna' AD	Sofia
Bulgaria	UMHAT 'Tsaritsa Yoanna - ISUL', EAD	Sofia
Bulgaria	MC "Orfey", EOOD	Stara Zagora
Bulgaria	SHATC "Cardiolife", OOD	Varna
Bulgaria	SHATC - Varna, EOOD	Varna
Bulgaria	MHAT "Sv. Panteleymon", AD	Yambol
Canada	LMC Clinical Research Inc. (Barrie)	Barrie	Ontario
Canada	Aggarwal and Associates Ltd	Brampton	Ontario
Canada	LMC Clinical Research Inc. (Brampton)	Brampton	Ontario
Canada	JBN Medical Diagnostic Services Inc.	Burlington	Ontario
Canada	LMC Clinical Research dba Manna Research Inc. Burlington North	Burlington	Ontario
Canada	LMC Clinical Research Inc. (Calgary)	Calgary	Alberta
Canada	Cambridge Cardiac Care Centre	Cambridge	Ontario
Canada	Joanne F. Liutkus Medicine Professional Corporation	Cambridge	Ontario
Canada	Saul Vizel Professional Medicine Corporation	Cambridge	Ontario
Canada	Ecogene-21	Chicoutimi	Quebec
Canada	LMC Clinical Research Inc. (Thornhill)	Concord	Ontario
Canada	ALTA Clinical Research Inc.	Edmonton	Alberta
Canada	Royal Alexandra Hospital, CK Hui Heart Centre	Edmonton	Alberta
Canada	LMC Clinical Research Inc. (Etobicoke)	Etobicoke	Ontario
Canada	ViaCar Recherche Clinique Inc	Greenfield Park	Quebec
Canada	Dawson Road Family Medical Clinic	Guelph	Ontario
Canada	Clinique de Cardiologie de Levis	Lévis	Quebec
Canada	Centre de Dépistage et Recherche Cardiovasculaire Rive-Sud	Longueuil	Quebec
Canada	LMC Clinical Research dba Manna Research Inc. Mirabel	Mirabel	Quebec
Canada	Applied Medical Informatics Research Inc.	Montreal	Quebec
Canada	CHUM Hôtel-Dieu	Montreal	Quebec
Canada	Clinique Santé Cardio MC	Montréal	Quebec
Canada	LMC Clinical Research Inc. (Ottawa)	Nepean	Ontario
Canada	Fraser Clinical Trials Inc.	New Westminster	British Columbia
Canada	LMC Clinical Research Inc. (Oakville)	Oakville	Ontario
Canada	James Cha, MD	Oshawa	Ontario
Canada	The Ottawa Hospital - Riverside Campus	Ottawa	Ontario
Canada	Kawartha Cardiology Clinical Trials	Peterborough	Ontario
Canada	Clinique des maladies Lipidiques de Quebec	Quebec
Canada	DIEX Recherche Quebec Inc.	Quebec
Canada	Institut Universitaire de Cardiologie et de Pneumologie de Quebec	Quebec
Canada	ALPHA Recherche Clinique	Québec	Quebec
Canada	Clinique Médicale St-Louis (Recherche) inc d/b/a/ Centre de Recherche Saint-Louis	Québec	Quebec
Canada	Recherche Clinique Sigma Inc.	Québec	Quebec
Canada	The Bailey Clinic	Red Deer	Alberta
Canada	LMC Clinical Research Inc. (Montreal)	Saint-Laurent	Quebec
Canada	Scarborough Cardiology Research	Scarborough	Ontario
Canada	Recherche Médicale St-Jérôme Inc.	St-Jérôme	Quebec
Canada	Centre Medical des Carrieres	St-Marc-des-Carrieres	Quebec
Canada	Health Sciences Centre	St. John's	Newfoundland and Labrador
Canada	Janik Research	Sudbury	Ontario
Canada	Surrey Memorial Hospital	Surrey	British Columbia
Canada	Humber River Hospital	Toronto	Ontario
Canada	LMC Clinical Research dba Manna Research Inc. Toronto	Toronto	Ontario
Canada	LMC Clinical Research Inc. (Bayview)	Toronto	Ontario
Canada	St. Michael's Hospital	Toronto	Ontario
Canada	BC Diabetes As Operated by Dr. TG Elliott, Inc.	Vancouver	British Columbia
Canada	Discovery Clinical Services Ltd.	Victoria	British Columbia
Canada	Rivergrove Medical Clinic	Winnipeg	Manitoba
Canada	Saint Boniface General Hospital	Winnipeg	Manitoba
Canada	Winnipeg Clinic	Winnipeg	Manitoba
Colombia	Centro de Investigacion Medico Asistencial S.A.S	Barranquilla
Colombia	IPS Centro Cientifico Asistencial S.A.S	Barranquilla
Colombia	Dexa Diab Servicios Médicos Limitada.	Bogota
Colombia	Solano y Terront Servicios Médicos Ltda.	Bogota
Colombia	Centro Cardiovascular Aristides Sotomayor Santa Lucia S.A.S. - IPS ASTALUC S.A.S. IPS	Cartagena
Colombia	Fundación Centro de Investigaciones Biomédicas Riescard	Espinal
Colombia	Fundación Oftalmológica de Santander - FOSCAL	Floridablanca
Colombia	Centro de Investigación Clínica CIC	Medellin
Czechia	Medicentrum Beroun spol. s.r.o.	Beroun
Czechia	Fakultni nemocnice u sv. Anny v Brne	Brno
Czechia	Nemocnice Milosrdnych bratri	Brno
Czechia	EDUMED s.r.o	Broumov
Czechia	Poliklinika Chocen a.s.	Chocen
Czechia	Ordinace pro choroby srdce s.r.o.	Chomutov
Czechia	MUDr. Jan Hubac s.r.o.	Chrudim
Czechia	Nemocnice Havlickuv Brod p.o.	Havlickuv Brod
Czechia	Kardio-Pisova s.r.o.	Hradec Kralove
Czechia	MUDr. Tomas Edelsberger	Krnov
Czechia	EDUMED s.r.o	Nachod
Czechia	Agentura Science Pro Spol. s.r.o.	Olomouc
Czechia	PreventaMed s.r.o.	Olomouc
Czechia	CCR Ostrava s.r.o.	Ostrava
Czechia	Corintez s.r.o.	Prague
Czechia	Synexus Czech s.r.o.	Praha
Czechia	Nemocnice na Frantisku	Praha 1
Czechia	MUDr. Jan KVASNICKA CSc. Angiologie kardiologie a interna	Praha 10
Czechia	Vseobecna fakultni nemocnice v Praze	Praha 2
Czechia	ResTrial s.r.o.	Praha 8
Czechia	MUDr.Eva Mandakova MBA	Rakovnik
Czechia	Nemocnice Slany	Slany
Czechia	AeskuLab k.s.	Teplice
Czechia	Kardiologicka ambulance MUDr. Ferkl s.r.o.	Trutnov
Czechia	Clinical Trials Services s.r.o	Uherske Hradiste
Czechia	MUDr. Nina Zemkova s.r.o.	Uherske Hradiste
Denmark	Ålborg Universitets Hospital	Aalborg
Denmark	Bioclinica	Aalborg
Denmark	Aarhus University Hospital	Aarhus
Denmark	Bioclinica	Ballerup
Denmark	Amager-Hvidovre Hospital	Copenhagen S
Denmark	Sydvestjyds Sygehus Esbjerg	Esbjerg
Denmark	Amager-Hvidovre Hospital	Glostrup
Denmark	Herlev og Gentofte Hospital	Hellerup
Denmark	Herlev og Gentofte Hospital	Herlev
Denmark	Regionshospitalet Herning-Hospitalsenheden Vest	Herning
Denmark	Holbæk Sygehus	Holbæk
Denmark	Sjællands Universitetshospital	Roskilde
Denmark	OUH	Svendborg
Denmark	Bioclinica	Vejle
France	CHU Tours - Hôpital Trousseau	Chambray Les Tours	Indre Et Loire
France	CHU Nantes - Hopital Nord Laënnec	Nantes cedex 01	Loire Atlantique
France	Hôpital Bichat - Claude Bernard	Paris cedex 18	Paris
Germany	Neurologische Praxis Dr. Schoell & Kollegen	Bad Homburg	Hessen
Germany	Diabetespraxis Prenzlauer Allee	Berlin
Germany	Institut fuer klinische Forschung und Entwicklung Berlin GmbH	Berlin
Germany	Studienzentrum Rankestrasse	Berlin
Germany	Synexus Clinical Research GmbH	Berlin
Germany	Synexus Clinical Research GmbH	Bochum	Nordrhein Westfalen
Germany	Gemeinschaftspraxis Diabeteszentrum Dortmund Dr.med. Klaus Busch	Dortmund	Nordrhein Westfalen
Germany	Kardiologische Praxis Gemeinschaftspraxis	Dortmund	Nordrhein Westfalen
Germany	Klinikum Bielefeld gem. GmbH	Dortmund	Nordrhein Westfalen
Germany	St. Johannes Hospital	Dortmund	Nordrhein Westfalen
Germany	ZKS-Südbrandenburg -center for clinical studies Südbrandenburg GmbH	Elsterwerda	Brandenburg
Germany	Katholisches Krankenhaus "St. Johann Nepomuk"	Erfurt	Thueringen
Germany	ClinPhenomics GmbH & Co KG	Frankfurt	Hessen
Germany	Synexus Clinical Research GmbH	Frankfurt	Hessen
Germany	Universitaetsklinikum Freiburg	Freiburg	Baden Wuerttemberg
Germany	Gemeinschaftspraxis fuer innere Medizin und Diabetologie	Hamburg
Germany	Gemeinschaftspraxis Dr. Klein/ Minnich	Kuenzing	Bayern
Germany	Gemeinschaftspraxis Dr. Taeschner / Dr. Bonigut	Leipzig	Sachsen
Germany	Synexus Clinical Research GmbH	Leipzig	Sachsen
Germany	Deutsches Herzzentrum Muenchen	Muenchen	Bayern
Germany	Klinikum der Universitaet Muenchen	Muenchen	Bayern
Germany	GP Dr. Haggenmiller, PD Dr. Michael Jeserich	Naumburg	Bayern
Germany	Dr. Uwe Böckmann / Birgit Jacobs - Diabeteszentrum Neumünster	Neumünster	Schleswig Holstein
Germany	RED - Institut GmbH	Oldenburg	Schleswig Holstein
Germany	Klinische Forschung Schwerin GmbH	Schwerin	Mecklenburg Vorpommern
Germany	Zentrum fuer Praevention und Rehabilitation	Siegen	Nordrhein Westfalen
Germany	Praxis fuer Praevention und Therapie	Villingen-Schwenningen	Baden Wuerttemberg
Hungary	Lausmed Kft.	Baja
Hungary	Principal SMO Kft.	Baja
Hungary	DRC Gyogyszervizsgalo Kozpont Kft.	Balatonfured
Hungary	Bekes Megyei Kozponti Korhaz Dr. Rethy Pal Tagkorhaz	Bekescsaba
Hungary	Belgyogyaszati es Kardiologiai Maganrendelo	Bekescsaba
Hungary	Clinexpert Kft.	Budapest
Hungary	CSALADGYOGYASZ Kft.	Budapest
Hungary	Semmelweis Egyetem	Budapest
Hungary	Synexus Magyarorszag Kft.	Budapest
Hungary	Borvo Clinic Kft.	Debrecen
Hungary	Debreceni Egyetem	Debrecen
Hungary	Meditoll Kft.	Godollo
Hungary	Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaza	Gyula
Hungary	Synexus Magyarorszag Egeszsegugyi Szolgaltato Kft.- Gyula DRS	Gyula
Hungary	BKS Research Kft.	Hatvan
Hungary	Z+P MED Egeszsegugyi, Kereskedelmi es Szolgaltato Bt.	Kalocsa
Hungary	Somogy Megyei Kaposi Mor Oktato Korhaz	Kaposvar
Hungary	Selye Janos Korhaz	Komarom
Hungary	IPR Hungary Kft.	Miskolc
Hungary	Kanizsai Dorottya Korhaz	Nagykanizsa
Hungary	BORBANYA PRAXIS Kft.	Nyiregyhaza
Hungary	Medifarma-98 Kft.	Nyiregyhaza
Hungary	Dr. Nagy Laszlo Kardiologiai Maganrendeles	Oroshaza
Hungary	Da Vinci Maganklinika	Pecs
Hungary	Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz	Szekesfehervar
Hungary	Tolna Megyei Balassa Janos Korhaz	Szekszard
Hungary	Csolnoky Ferenc Korhaz	Veszprem
Hungary	Zala Megyei Szent Rafael Korhaz	Zalaegerszeg
India	Ahmedabad Bariatrics and Cosmetics Pvt Ltd.	Ahmedabad	Gujarat
India	S. A. L. Hospital & Medical Institute	Ahmedabad	Gujarat
India	Fortis Hospitals Ltd.	Bangalore	Karnataka
India	K.L.E. Society's Dr. Prabhakar Kore Hospital and Medical Research Centre	Belgaum	Karnataka
India	Institute of Medical Sciences and SUM Hospital	Bhubaneshwar	Orissa
India	Institute of Cardiovascular Diseases Madras Medical Mission	Chennai	Tamilnadu
India	SRM Institutes for Medical Sciences	Chennai	Tamilnadu
India	Maharaja Agrasen Hospital	Delhi
India	Medanta The Medicity	Gurgaon	Haryana
India	GNRC Hospital	Guwahati	Assam
India	Eternal Heart Care Centre	Jaipur	Rajasthan
India	IPGMER and SSKM Hospital	Kolkata	West Bengal
India	KRM Hospital & Research Centre	Lucknow	Uttar Pradesh
India	JSS Hospital	Mysuru	Karnataka
India	DDMM Heart Institute	Nadiad	Gujarat
India	Meditrina Institute Of Medical Sciences	Nagpur	Maharashtra
India	Supe Heart & Diabetes Hospital & Research Centre	Nashik	Maharashtra
India	Vijaya Super Speciality Hospital	Nellore	Andhra Pradesh
India	Fortis Flight Lieutenant Rajan Dhall Hospital	New Delhi	Delhi
India	Loknayak Hospital	New Delhi	Delhi
India	Sir Gangaram Hospital	New Delhi	Delhi
India	7-Orange Hospital	Pimpri-Chinchwad	Maharashtra
India	King Edward Memorial Hospital Research Centre	Pune	Maharashtra
India	Shree Multispecialty Hospital	Pune	Maharashtra
India	BAPS Pramukhswami Hospital	Surat	Gujarat
India	Shri B. D. Mehta Mahavir Heart Institute	Surat	Gujarat
India	Medical College	Thiruvananthapuram	Kerala
India	Aashirwad Hospital	Ulhasnagar	Maharashtra
India	Rhythm Heart Institute	Vadodara	Gujarat
India	Sterling Hospital	Vadodara	Gujarat
India	Galaxy Hospital	Varanasi	Uttar Pradesh
Israel	HaEmek Medical Center	Afula
Israel	Bnai Zion Medical Center	Haifa
Israel	Rambam Health Care Center	Haifa
Israel	The Lady Davis Carmel Medical Center	Haifa
Israel	Wolfson Medical Center	Holon
Israel	Hadassah University Hospital - Ein Kerem	Jerusalem
Israel	Shaare Zedek Medical Center	Jerusalem
Israel	Galilee Medical Center	Nahariya
Israel	Rabin Medical Center-Beilinson Campus	Petach Tikva
Israel	Chaim Sheba Medical Center	Ramat-Gan
Israel	Kaplan Medical Center	Rechovot
Israel	Ziv Medical Center	Safed
Israel	Diabetes Medical Center	Tel Aviv
Israel	Tel Aviv Sourasky Medical Center	Tel Aviv
Japan	Juntendo University Hospital	Bunkyo-ku	Tokyo-To
Japan	Chiba University Hospital	Chiba-shi	Chiba-Ken
Japan	Fukuwa Clinic	Chuo-ku	Tokyo-To
Japan	Tokyo-Eki Center-Building Clinic	Chuo-Ku	Tokyo-To
Japan	Nakahama Heart Clinic	Fuchu-shi	Hiroshima-Ken
Japan	Fukuoka University Hospital	Fukuoka-shi	Fukuoka-Ken
Japan	Nippon Kokan Fukuyama Hospital	Fukuyama-shi	Hiroshima-Ken
Japan	Public Central Hospital of Matto Ishikawa	Hakusan-shi	Ishikawa-Ken
Japan	NHO Hamada Medical Center	Hamada-shi	Shimane-Ken
Japan	NHO Higashihiroshima Medical Center	Higashihiroshima-shi	Hiroshima-Ken
Japan	Iwasaki Naika Clinic	Higashiosaka-shi	Osaka-Fu
Japan	Takekawa Naika Clinic	Higashiosaka-shi	Osaka-Fu
Japan	Tanaka Cardiology Clinic	Hitachinaka-shi	Ibaraki-Ken
Japan	IMS Miyoshi General Hospital	Iruma-gun	Saitama-Ken
Japan	Nomura Clinic	Itabashi-ku	Tokyo-To
Japan	Rinku General Medical Center	Izumisano-shi	Osaka-Fu
Japan	Shiraiwa Medical Clinic	Kashiwara-shi	Osaka-Fu
Japan	Fukuoka Tokushukai Hospital	Kasuga-shi	Fukuoka-Ken
Japan	Hosoda Clinic	Katsushika-ku	Tokyo-To
Japan	Sugiura Clinic	Kawaguchi-shi	Saitama-Ken
Japan	Tokushukai Kishiwada Tokushukai Hospital	Kishiwada-shi	Osaka-Fu
Japan	Steel Memorial Yawata Hospital	Kitakyushu-shi	Fukuoka-Ken
Japan	NHO Fukuoka Higashi Medical Center	Koga-shi	Fukuoka-Ken
Japan	NHI Komatsu Municipal Hospital	Komatsu-shi	Ishikawa-Ken
Japan	Hoshi General Hospital	Koriyama-shi	Fukushima-Ken
Japan	Southern Tohoku Medical Clinic	Koriyama-shi	Fukushima-Ken
Japan	Kumamoto University Hospital	Kumamoto-shi	Kumamoto-Ken
Japan	Ijinkai Takeda General Hospital	Kyoto-shi	Kyoto-Fu
Japan	Kyoto University Hospital	Kyoto-shi	Kyoto-Fu
Japan	Rakuwakai Otowa Hospital	Kyoto-shi	Kyoto-Fu
Japan	Kioroshikai Chibanishi General Hospital	Matsudo-shi	Chiba-Ken
Japan	Seikeikai New Tokyo Heart Clinic	Matsudo-shi	Chiba-Ken
Japan	Ehime Prefectural Central Hospital	Matsuyama-shi	Ehime-Ken
Japan	Toyukai Yutenji Medical Clinic (Yutenji Naika)	Meguro-ku	Tokyo-To
Japan	Iwate Medical University Uchimaru Medical Center Hospital	Morioka-shi	Iwate-Ken
Japan	Kuonkai Kamata Medical Clinic	Morioka-shi	Iwate-Ken
Japan	Aichi Medical University Hospital	Nagakute-shi	Aichi-Ken
Japan	JOHAS Chubu Rosai Hospital	Nagoya-shi	Aichi-Ken
Japan	Kojunkai Daido Clinic	Nagoya-shi	Aichi-Ken
Japan	NHO Nagoya Medical Center	Nagoya-shi	Aichi-Ken
Japan	Nakakinen Clinic Medical Corporation Kensei-kai	Naka-shi	Ibaraki-Ken
Japan	Okinawa Tokushukai Chubu Tokushukai Hospital	Nakagami-gun	Okinawa-Ken
Japan	National Center For Geriatrics And Gerontology	Obu-shi	Aichi-Ken
Japan	Keiwakai Oita Oka Hospital	Oita-shi	Oita-Ken
Japan	Okayama University Hospital	Okayama-shi	Okayama-Ken
Japan	Chiyukai Fukuoka Shinmizumaki Hospital	Onga-gun	Fukuoka
Japan	Kansai Electric Power Hospital	Osaka-shi	Osaka-Fu
Japan	Sato Hospital	Osaki-shi	Miyagi-Ken
Japan	Shiga University of Medical Science Hospital	Otsu-shi	Shiga-Ken
Japan	Sohken Yamamoto Clinic	Sagamihara-shi	Kanagawa-Ken
Japan	Miyanosawa Clinic of Internal Medicine and Cardiology	Sapporo-shi	Hokkaido
Japan	Sendai Kousei Hospital	Sendai-shi	Miyagi-Ken
Japan	Tohoku Kosai Hospital	Sendai-shi	Miyagi-Ken
Japan	Jichi Medical University Hospital	Shimotsuke-shi	Tochigi-Ken
Japan	Shinjuku Research Park Clinic	Shinjuku-ku	Tokyo-To
Japan	National Cerebral and Cardiovascular Center	Suita-shi	Osaka-Fu
Japan	Josuikai Olive Takamatsu Medical Clinic	Takamatsu-shi	Kagawa-Ken
Japan	Ryubokai Higashi Diabetes and Cardiovascular Clinic	Tamana-shi	Kumamoto-Ken
Japan	Sanyukai Saino Clinic	Tokorozawa-shi	Saitama-Ken
Japan	Fujita Health University Hospital	Toyoake-shi	Aichi-Ken
Japan	Senrichuo Ekimae Clinic	Toyonaka-shi	Osaka-Fu
Japan	Yamaguchi University Hospital	Ube-shi	Yamaguchi-Ken
Japan	NHO Saitama National Hospital	Wako-shi	Saitama-Ken
Japan	NHO Yokohama Medical Center	Yokohama-shi	Kanagawa-Ken
Mexico	Centro de Investigacion Clinica del Pacifico, S.A. de C.V.	Acapulco de Juárez	Guerrero
Mexico	Centro de Investigacion Cardiometabolica de Aguascalientes S.A de C.V	Aguascalientes
Mexico	Investigacion En Salud Y Metabolismo S.C.	Chihuahua
Mexico	Instituto de Diabetes, Obesidad y Nutrición S.C.	Cuautla	Morelos
Mexico	Cardiologia Clinica e Intervencionista	Guadalajara	Jalisco
Mexico	Centro de Estudios de Investigacion Metabolicos y Cardiovasculares S.C.	Madero	Tamaulipas
Mexico	Centro de Atención e Investigación en Factores de Riesgo Cardiovascular Omega S.C.	Mexico	Distrito Federal
Mexico	Health Pharma Professional Research S.A. de C.V.	Mexico	Distrito Federal
Mexico	Instituto Nacional de Ciencias Médicas y Nutricion Dr. Salvador Zubiran	Mexico	Distrito Federal
Mexico	Mentrials S.A. de C.V.	Mexico	Distrito Federal
Mexico	Phytomedicamenta S.A. de C.V.	Mexico	Distrito Federal
Mexico	Centro Medico San Francisco	Monterrey	Nuevo León
Mexico	Universidad Autonoma de Nuevo Leon, Hospital Universitario Dr. Jose Eleuterio Gonzalez	Monterrey	Nuevo León
Mexico	Centro Integral Medico SJR S.C.	San Juan del Rio	Queretaro
Mexico	Unidad Medica para la Salud Integral	San Nicolas de los Garza	Nuevo León
Mexico	Centro de Investigacion Cardiovascular y Metabolica	Tijuana	Baja California Norte
Mexico	Sociedad de Metabolismo y Corazon S.C	Veracruz
Mexico	Centro de Investigacion Medica de Occidente, S.C.	Zapopan	Jalisco
Netherlands	Noordwest Ziekenhuisgroep	Alkmaar
Netherlands	Ziekenhuisgroep Twente, Almelo	Almelo
Netherlands	Meander Medisch Centrum	Amersfoort
Netherlands	Ziekenhuis Amstelland	Amstelveen
Netherlands	Amsterdam UMC, Locatie AMC	Amsterdam
Netherlands	BovenlJ Ziekenhuis	Amsterdam
Netherlands	Gelre ziekenhuizen, locatie Lukas	Apeldoorn
Netherlands	Rijnstate	Arnhem
Netherlands	Haga Ziekenhuis	Den Haag
Netherlands	Deventer Ziekenhuis	Deventer
Netherlands	Albert Schweitzer Ziekenhuis, Dordwijk	Dordrecht
Netherlands	Gelderse Vallei Ziekenhuis, Ede	Ede
Netherlands	Catharina Ziekenhuis Eindhoven	Eindhoven
Netherlands	Spaarne Gasthuis, Hoofddorp	Haarlem
Netherlands	Zuyderland Medisch Centrum - Heerlen	Heerlen
Netherlands	Huisartsenpraktijk Gorecht	Hoogezand
Netherlands	Quality Care Research	Kloosterhaar
Netherlands	Leids Universitair Medisch Centrum	Leiden
Netherlands	Bravis Ziekenhuis, Roosendaal	Roosendaal
Netherlands	Ikazia Ziekenhuis	Rotterdam
Netherlands	Maasstad Ziekenhuis, Zuider	Rotterdam
Netherlands	Albert Schweitzer Ziekenhuis, Zwijndrecht	Sliedrecht
Netherlands	Bernhoven Uden	Uden
Netherlands	Diakonessenhuis, Utrecht	Utrecht
Netherlands	UMC Utrecht	Utrecht
Netherlands	Maxima Medisch Centrum	Veldhoven
Netherlands	VieCuri Medisch Centrum	Venlo
Poland	NZOZ Centrum Medyczne KERmed	Bydgoszcz
Poland	KARDIOMED Janczska Kociwska Ostki PodckaRekrzSp	Elblag
Poland	Poradnia Kardiologiczna Jaroslaw Jurowiecki	Gdansk
Poland	Synexus Polska SCM Sp. z o.o. Gdansku	Gdansk
Poland	Uniwersyteckie Centrum Kliniczne	Gdansk
Poland	Indywidualna Specjalistyczna Praktyka Lekarska w Dziedzinie Kardiologii lek. med. Krzysztof Cymerman	Gdynia
Poland	Synexus Polska Sp. z o.o. Oddzial w Gdyni	Gdynia
Poland	Samodzielny Publiczny Specjalistyczny Szpital Zachodni im. Jana Pawla II	Grodzisk Mazowiecki
Poland	Centrum Medyczne Pratia Katowice II	Katowice
Poland	SPSK Nr 7 SUM w Katowicach Gornoslaskie CM im. prof. Leszka Gieca	Katowice
Poland	Synexus Polska Sp. z o.o. Oddzial w Katowicach	Katowice
Poland	Specjalistyczna Poradnia Kardiologiczna i Nadcisnienia Tetniczego	Kielce
Poland	Augustyn Monika	Krakow
Poland	Krakowskie Centrum Medyczne Sp. z o.o.	Krakow
Poland	Indywidualna Specjalistyczna Praktyka Lekarska	Lodz
Poland	NZOZ ALL-MED Centrum Medyczne Specjalistyczne Gabinety Lekarskie	Lodz
Poland	Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi	Lodz
Poland	Clinical Best Solutions	Lublin
Poland	KO-MED Centra Kliniczne Lublin II	Lublin
Poland	NZOZ Twoja Przychodnia	Lublin
Poland	NZOZ Osrodek Kardiologii Inwazyjnej -Ikardia	Naleczow
Poland	Medicome Sp. z o.o.	Oswiecim
Poland	Praktyka Lekarska Ewa Krzyzagorska	Poznan
Poland	Synexus Polska sp. z o.o. Oddzial w Poznaniu	Poznan
Poland	KO-MED Centra Kliniczne Pulawy	Pulawy
Poland	NZOZ Przychodnia Specjalistyczna H. Rudzki, A. Wittek	Ruda Slaska
Poland	Centrum Medyczne Medyk	Rzeszow
Poland	Clinmed Research	Skierniewice
Poland	NZOZ Pro-Cordis Sopockie Centrum Bad. Kardiolog.	Sopot
Poland	NSZOZ Medicus	Sroda Wielkopolska
Poland	KO-MED Centra Kliniczne Staszow	Staszow
Poland	Indywidualna Specjalistyczna Praktyka Lekarska dr n. med. Agnieszka Karczmarczyk Specjalista Chorob	Szczecin
Poland	NBR Polska	Warsaw
Poland	Centrum Medyczne Swiat Pacjenta	Warszawa
Poland	Synexus Polska Sp. z o.o. Oddzial w Warszawie	Warszawa
Poland	Centrum Zdrowia Tuchow Sp. z o.o.	Wierzchoslawice
Poland	Synexus Polska Sp. z o.o. Oddzial we Wroclawiu	Wroclaw
Poland	KO-MED Centra Kliniczne Zamosc	Zamosc
Puerto Rico	VA Medical Center - San Juan	San Juan
Romania	S.C. CMI Dr. Pletea Noemi S.R.L	Bacau
Romania	Cabinet Medical Individual Diabet, Nutritie, Boli Metabolice Dr. Pop Lavinia	Baia Mare
Romania	S.C Centrul Medical de Diagnostic si Tratament Ambulator Neomed S.R.L	Brasov
Romania	Institutul de Urgenta pentru Boli Cardiovasculare "Prof. Dr. C.C. Iliescu"	Bucharest
Romania	CMI Dr. Stolea T. Violeta - Medic specialist diabet zaharat, nutritie si boli metabolice	Bucuresti
Romania	S.C Clinica Medicala Data Plus S.R.L	Bucuresti
Romania	S.C Policlinica CCBR S.R.L	Bucuresti
Romania	S.C. Health Net S.R.L	Bucuresti
Romania	Spitalul Clinic Colentina	Bucuresti
Romania	Spitalul Clinic de Urgenta "Sfantul Pantelimon"	Bucuresti
Romania	S.C. Medcon S.R.L.	Buzau
Romania	S.C Grandmed S.R.L	Oradea
Romania	S.C Pelican Impex S.R.L	Oradea
Romania	S.C. Bella Praxis S.R.L	Pa?cani
Romania	CMI Dr Busegeanu Mihaela Magdalena	Ploiesti
Romania	S.C. Diabmed Dr. Popescu Alexandrina S.R.L	Ploiesti
Romania	S.C Mediab S.R.L	Targu Mures
Romania	S.C Medicali's S.R.L	Timisoara
Romania	Spitalul Clinic Judetean de Urgenta "Pius Brinzeu"	Timisoara
Russian Federation	SBIH of Arkhangelsk region " First City Clinical hospital n.a. E. E. Volosevich"	Arkhangelsk
Russian Federation	TSHI "Altay Territorial Cardiologocal dispensary"	Barnaul
Russian Federation	SEIHPE "Ural SMA of RosZdrav" b.o. LLC "City Hospital #41"	Ekaterinburg
Russian Federation	FSBI "Scientific-research Institute for Complex Problems of cardiovascular disease"	Kemerovo
Russian Federation	FSHI "MSU of MoIA of RF of Kemerovo Region"	Kemerovo
Russian Federation	NSIH "Departmental Hospital on Station Kemerovo of OJSC "Russian Railways"	Kemerovo
Russian Federation	SAIH "Kemerovo Regional Clinical Hospital"	Kemerovo
Russian Federation	TSBIH "Krasnoyarsk Interdistrict Clinical Hospital of Emergency Medical Care n.a. N.S. Karpovich	Krasnoyarsk
Russian Federation	FSBI "Central Clinical Hospital with Polyclinic of the Department for Presidential Affairs of the RF	Moscow
Russian Federation	FSBIH "Central Clinical Hospital of Russian Academy of Sciences"	Moscow
Russian Federation	SBEI HPE "Moscow State Medical and Dentistry University n.a. A. I. Evdokimov" of the MoH of the RF	Moscow
Russian Federation	SBEI HPE "Moscow State Medical and Dentistry University n.a. A. I. Evdokimov" of the MoH of the RF	Moscow
Russian Federation	SBHI "City Polyclinic #2 of Healthcare department of city of Moscow"	Moscow
Russian Federation	SBIH of Moscow "City Clinical Hospital n.a.Bakhrushinykh"	Moscow
Russian Federation	Murmansk Regional Clinical Hospital named after Bayandin	Murmansk
Russian Federation	FSBSI "Scientific Research Institute of Therapy and Preventive Medicine"	Novosibirsk
Russian Federation	LLC "RC Medical"	Novosibirsk
Russian Federation	SBIH of Novosibirsk region "City Clinical Hospital # 19"	Novosibirsk
Russian Federation	SBIH of Novosibirsk Region "Clinical Emergency Hospital #2"	Novosibirsk
Russian Federation	BIH of Omsk region "Clinical Medico-Sanitary Unit # 9	Omsk
Russian Federation	Llc Ultramed	Omsk
Russian Federation	SBIH of Perm territory " City Clinical Hospital # 2 n.a. Fedor Khristoforovich Gral"	Perm
Russian Federation	SHI "Perm Regional Hospital of War Veterans"	Perm
Russian Federation	State Budgetary Healthcare Institution Clinical Medical Sani	Perm
Russian Federation	City Emergency Hospital #2	Rostov-on-Don
Russian Federation	CJSC Clinic complex	Saint-Petersburg
Russian Federation	FSBI North-West Federal Medical Research Center n.a. V.A. Almazov of MoH RF	Saint-Petersburg
Russian Federation	LLC Medical Center Mart	Saint-Petersburg
Russian Federation	Pavlov First Saint Petersburg State Medical University	Saint-Petersburg
Russian Federation	Saint-Petersburg SBHI "City outpatient clinic #28"	Saint-Petersburg
Russian Federation	SPb SBIH "City Pokrovskaya Hospital"	Saint-Petersburg
Russian Federation	SIH "Saratov City Clinical Hospital # 2 n.a. V.I. Razumovskiy"	Saratov
Russian Federation	SPb SBIH "City Hospital # 40 of Kurortnyi region"	Sestroretsk
Russian Federation	LLC "Institute of Medical Examinations"	St. Petersburg
Russian Federation	Llc "Medinet"	St. Petersburg
Russian Federation	SPb SBIH "City Multy-field Hospital # 2"	St. Petersburg
Russian Federation	SPb SBIH "Nikolaevskaya Hospital"	St. Petersburg
Russian Federation	FSBI "Research Institute for Cardiology" of Siberian Branch RAMS	Tomsk
Russian Federation	SHI "Regional Clinical Hospital"	Tver
Russian Federation	SHI Ulyanovsk Reg Clinical Hospital	Ulyanovsk
Russian Federation	Yaroslavl Regional Clinical Hospital of War Veterans	Yaroslavl
Slovakia	Alian s.r.o.	Bardejov
Slovakia	Thyreomedical s.r.o.	Bardejov
Slovakia	Diabet, spol. s.r.o.	Bratislava
Slovakia	DIAFA s.r.o.	Bratislava
Slovakia	Galenum, s.r.o.	Bratislava
Slovakia	Kardiologicka, interna a sonograficka amb. Kardio-Sanus, sro	Bratislava
Slovakia	Kardiovaskularne centrum, s.r.o.	Bratislava
Slovakia	MEDISPEKTRUM PLUS s.r.o.	Bratislava
Slovakia	Metabol KLINIK s.r.o.	Bratislava
Slovakia	MUDr. Vladimir Gergel, s.r.o.	Bratislava
Slovakia	ENDIAMED, s.r.o.	Dolny Kubin
Slovakia	MEDICUS plus s.r.o.	Komarno
Slovakia	Human-Care s.r.o.	Kosice
Slovakia	Sukromna interna a kardiologicka ambulancia	Kosice
Slovakia	CELL B, s.r.o.	Levice
Slovakia	DIA- Kontrol s.r.o.	Levice
Slovakia	IN-DIA s.r.o.	Lucenec
Slovakia	KARDIO 1 s.r.o.	Lucenec
Slovakia	MUDr. Zuzana Ochodnicka,	Nitra
Slovakia	Fakultna nemocnica s poliklinikou Nove Zamky	Nove Zamky
Slovakia	DIABETOL s.r.o.	Presov
Slovakia	Medispol s.r.o.	Presov
Slovakia	Nemocnica s poliklinikou sv. Barbory Roznava a.s.	Roznava
Slovakia	Peter Farkas MD, s.r.o.	Sahy
Slovakia	Interna SK s.r.o.	Svidnik
Slovakia	Nemocnica arm. generala L. Svobodu Svidnik, a.s.,	Svidnik
Slovakia	Diabetes centrum, s.r.o.	Trencin
Slovakia	JAL s.r.o.	Trnava
Slovakia	MEDIVASA s.r.o.	Zilina
South Africa	Cardiology Clinical Research	Alberton	Gauteng
South Africa	Cape Town Medical Research Centre	Cape Town	Western Cape
South Africa	Corbod Research	Cape Town	Western Cape
South Africa	Groote Schuur Hospital Lipid Laboratory	Cape Town	Western Cape
South Africa	Paarl Research Centre	Cape Town	Western Cape
South Africa	Synexus Helderberg Clinical Research Centre	Cape Town	Western Cape
South Africa	Tiervlei Trial Centre	Cape Town	Western Cape
South Africa	Tread Research	Cape Town	Western Cape
South Africa	Johese Clinical Research: Unitas	Centurion	Gauteng
South Africa	Lenasia Clinical Trial Centre	Johannesburg	Gauteng
South Africa	Medicross Roodepoort Clinical Research	Johannesburg	Gauteng
South Africa	Wits Clinical Research	Johannesburg	Gauteng
South Africa	Clinresco Centres (Pty) Ltd	Kempton Park	Gauteng
South Africa	Synexus SA - Stanza Clinical Research Centre	Mamelodi East	Gauteng
South Africa	Dr AA Mahomed Medical Centre	Moloto	Mpumalanga
South Africa	Emmed Research	Pretoria	Gauteng
South Africa	Johese Clinical Research: Midstream	Pretoria	Gauteng
South Africa	Seeber, M	Pretoria	Gauteng
South Africa	Synexus SA Watermeyer Clinical Research Centre	Pretoria	Gauteng
South Africa	Dr JM Engelbrecht Practice	Somerset West	Western Cape
South Africa	Helderberg Research Institute	Somerset West	Western Cape
South Africa	Limpopo Clinical Research Initiative	Thabazimbi	Limpopo
Spain	Complejo Hospitalario Universitario A Coruña	A Coruña	La Coruña
Spain	Hospital Virgen del Mar	Almeria
Spain	Hospital Universitari Germans Trias i Pujol	Badalona	Barcelona
Spain	Hospital de la Santa Creu i Sant Pau	Barcelona
Spain	Hospital del Mar	Barcelona
Spain	Hospital Quironsalud Barcelona	Barcelona
Spain	Hospital Universitari Vall d'Hebron	Barcelona
Spain	Hospital Universitario Reina Sofia	Cordoba	Córdoba
Spain	Hospital Universitario Ramon y Cajal	Madrid
Spain	Hospital Regional Universitario de Malaga	Málaga
Spain	Hospital Virgen del Camino	Sanlucar de Barrameda	Cádiz
Spain	Complejo Hospitalario Universitario de Santiago	Santiago de Compostela	La Coruña
Spain	Hospital Quironsalud Infanta Luisa	Sevilla
Spain	Hospital Universitario Virgen Macarena	Sevilla
Spain	Nuevas tecnologías en Diabetes y Endocrinología	Sevilla
Ukraine	Cherkasy Regional Cardiological Center	Cherkasy
Ukraine	CI Cherkasy RH of Cherkasy Regional Council	Cherkasy
Ukraine	CMI CCH#3 Dep of Ther# w the beds of card profile HSEI of UBSMU	Chernivtsi
Ukraine	RCI Chernivtsi Regional Endocrinology Center Policlinic Dept SHEI of UBSMU	Chernivtsi
Ukraine	CI Dnipropetrovsk City Cl Hosp #9 of Dniprop Reg Council SI DMA of MOH of Ukr Ch of Endocrinology	Dnipro
Ukraine	Medical Center of Limited Liability Company Medical Center Clinic of Family Medicine	Dnipro
Ukraine	CI Ivano-Frankivsk Reg Cl Card Center Dept of Chronic Ischemic Heart Dis SHEI Ivano-Frank NMU	Ivano-Frankivsk
Ukraine	Ivano-Frankivsk CCH Dept of Therapy #1 SHEI Ivano-Frankivsk NMU	Ivano-Frankivsk
Ukraine	Regional CH Dept of Endocrinology SHEI Ivano-Frankivsk NMU	Ivano-Frankivsk
Ukraine	CHI Kharkiv City Student Hosp Therap dept Nat Pharm Univer	Kharkiv
Ukraine	CNE City Clin Hosp #8 of KCC Dept of Therapy Kharkiv MA of PGE of MOHU	Kharkiv
Ukraine	CNE Prof. O.O. Shalimov Kharkiv City Clinical Hospital #2 KCC	Kharkiv
Ukraine	GI L.T.Malaya Therapy National Institute of the NAMS of Ukraine	Kharkiv
Ukraine	MC Doctor Alex Dept of General Practice-Family Medicine Kharkiv MA of PGE	Kharkiv
Ukraine	Railway Transport Kharkiv CH #1 of Healthcare Center Branch of PJSC Ukr Railway	Kharkiv
Ukraine	Railway Transport Kharkiv CH#1 of Healthcare Center Branch of PJSC Ukrainian Railway	Kharkiv
Ukraine	State Institution LT Malaya Inst. of Ther. of AMS of Ukraine	Kharkiv
Ukraine	CI Ye.Ye.Karabelesh Kherson City Clinical Hosp.	Kherson
Ukraine	CI of Kyiv RC Regional Clinical Hospital #2	Kyiv
Ukraine	Department of Medical Services and Rehabilitation of State Joint Stock Holding Company Artem	Kyiv
Ukraine	KCCC of Endocr Dept of General Endocrine Pathology O. O. Bogomolets NMU	Kyiv
Ukraine	Kyiv CCH #12 Dept of Therapy O.O.Bogomolets NMU	Kyiv
Ukraine	Kyiv CH on Railway Transport #2 of Branch Center of Healthcare Public Company Ukr Railway	Kyiv
Ukraine	LLC Treatment and Diagnostic Center Adonis Plus	Kyiv
Ukraine	MC of PHEI Institute of General Practice - Family Medicine	Kyiv
Ukraine	MC of Subsidiary Production Unit Med Scient Pract Union Medbud of PJSc Holding Company Kyivmiskbud	Kyiv
Ukraine	Med Center 'Ok!Clinic+' of International Institute of Clinical Trials LLC	Kyiv
Ukraine	Med Center of Eurolab LLC Policlinic Outpatient Dept O.O.Bogomolets NMU	Kyiv
Ukraine	Medical Center Blagomed Plus LLC	Kyiv
Ukraine	Medical Center of Limited Liability Company Medical Center Concilium Medical	Kyiv
Ukraine	SI National Scientific Centre of Radiation Medicine of NAMSU	Kyiv
Ukraine	SI NS? M.D. Strazhesko Institute of Cardiology of NAMSU	Kyiv
Ukraine	SI NSC M.D. Strazhesko Institute of Cardiology of NAMSU	Kyiv
Ukraine	SI V.P.Komisarenko Institute of E&M of NAMSU	Kyiv
Ukraine	SI V.P.Komisarenko Institute of Endocrinology and Metabolism of NAMSU	Kyiv
Ukraine	Lviv Communal 4th City Clinical Hospital	Lviv
Ukraine	Lviv Reg St Clin Treatment - Diagnostic Endocrin Center, Dept of Polyclinic, D.Galytskyy Lviv NMU	Lviv
Ukraine	Center of Reconstructive & Restorative Medicine (University Clinic) of Odessa National Medical Uni	Odesa
Ukraine	CI Sumy City Clinical Hospital #1 Dept of Therapy Sumy SU Med Inst	Sumy
Ukraine	Ternopil City Municipal Hospital #2 Dept of Gastroenterology Ternopil I.Ya. Gorbachevskyi SMU	Ternopil
Ukraine	Transcarpathian Regional Clinical Cardiology Dispansery	Uzhgorod
Ukraine	National Pirogov Memorial Medical University	Vinnytsia
Ukraine	Private Small Enterprise Medical Center Pulse	Vinnytsia
Ukraine	SRI of Invalid Rehabilitation (EST Complex) of Vinnytsia M.I.Pyrogov NMU MOHU	Vinnytsia
Ukraine	Vinnytsia RC Highly Special.Endocr.Center Dept of Therapy #2 M.I. Pyrogov NMU	Vinnytsia
Ukraine	CI Zapor CCH#10 SI ZMA PGE Ch of therapy clin pharmacol & endocrin	Zaporizhzhia
Ukraine	CI Central City Hospital #1 of Zhytomyr	Zhytomyr
Ukraine	Zhytomyr regional clinical hospital n.a. O.F. Gerbachevskyy	Zhytomyr
United Kingdom	Synexus Birmingham Clinical Research Centre	Birmingham	West Midlands
United Kingdom	Waterloo Medical Centre	Blackpool	Lancashire
United Kingdom	Synexus Wales Clinical Research Centre	Cardiff	South Glamorgan
United Kingdom	Broomfield Hospital	Chelmsford	Essex
United Kingdom	Synexus Lancashire Clinical Research Centre	Chorley	Lancashire
United Kingdom	Ninewells Hospital	Dundee	Tayside Region
United Kingdom	Synexus Scotland Clinical Research Centre	Glasgow	Strathclyde
United Kingdom	Mounts Bay Medical Ltd	Hayle	Cornwall
United Kingdom	Synexus Hexham General Hospital	Hexham	Northumberland
United Kingdom	Oak Tree Surgery	Liskeard	Cornwall
United Kingdom	Synexus Merseyside Clinical Research Centre	Liverpool	Merseyside
United Kingdom	Barts Hospital	London	Greater London
United Kingdom	Manchester Royal Infirmary	Manchester	Greater Manchester
United Kingdom	Synexus Manchester Clinical Research Centre	Manchester	Greater Manchester
United Kingdom	The Alverton Practice	Penzance	Cornwall
United Kingdom	Knowle House Surgery	Plymouth	Devon
United Kingdom	Synexus Thames	Reading	Berkshire
United Kingdom	Synexus Clinical Research North Tees	Stockton on Tees	Durham
United Kingdom	Morriston Hospital	Swansea
United Kingdom	Rame Medical Limited	Torpoint	Cornwall
United Kingdom	Torbay Hospital	Torquay	Devon
United States	Synexus Clinical Research US, Inc.	Akron	Ohio
United States	Endocrine Group, L.L.P.	Albany	New York
United States	Stratton Veterans Affairs Medical Center - Albany	Albany	New York
United States	Raymond G. Murphy VA Medical Center	Albuquerque	New Mexico
United States	Cambridge Medical Trials	Alexandria	Louisiana
United States	Clinical Research Alliance, Inc	Alhambra	California
United States	Community Hospital of Anderson and Madison County, Inc.	Anderson	Indiana
United States	Synexus Clinical Research US, Inc.	Anderson	South Carolina
United States	University of Michigan	Ann Arbor	Michigan
United States	Veterans Affairs Ann Arbor Healthcare System	Ann Arbor	Michigan
United States	Randolph Medical Associates	Asheboro	North Carolina
United States	OnSite Clinical Solutions, LLC	Asheville	North Carolina
United States	OhioHealth Heart & Vascular Physicians (Heartcare, Inc.) - Athens	Athens	Ohio
United States	Emory University	Atlanta	Georgia
United States	Lynn Institute of Denver	Aurora	Colorado
United States	Central Texas Clinical Research, LLC	Austin	Texas
United States	Baltimore VA medical centre	Baltimore	Maryland
United States	Maryland Cardiovascular Specialists	Baltimore	Maryland
United States	University of Maryland School of Medicine	Baltimore	Maryland
United States	Bay Pines VA Healthcare System	Bay Pines	Florida
United States	Southern Maine Health Care	Biddeford	Maine
United States	Alabama Clinical Therapeutics, LLC	Birmingham	Alabama
United States	Synexus Clinical Research US, Inc.	Birmingham	Alabama
United States	University of Alabama at Birmingham	Birmingham	Alabama
United States	VA Medical Center - Birmingham	Birmingham	Alabama
United States	Joslin Diabetes Center	Boston	Massachusetts
United States	Meridien Research	Bradenton	Florida
United States	Clinical Research Of Brandon, LLC	Brandon	Florida
United States	PMG Research of Bristol, LLC	Bristol	Tennessee
United States	Northern Pines Health Center	Buckley	Michigan
United States	Buffalo VA Medical Center	Buffalo	New York
United States	Burke Internal Medicine & Research	Burke	Virginia
United States	Kernodle Clinic, Inc., Dept. of the Private Diagnostic Clinic, PLLC	Burlington	North Carolina
United States	Cadillac Clinical Research, LLC	Cadillac	Michigan
United States	Aultman Hospital	Canton	Ohio
United States	Cary Research Group, LLC	Cary	North Carolina
United States	PMG Research of Cary, LLC	Cary	North Carolina
United States	Chambersburg Hospital	Chambersburg	Pennsylvania
United States	Christie Clinic, LLC	Champaign	Illinois
United States	Synexus Clinical Research US, Inc.	Chandler	Arizona
United States	Ralph H. Johnson VA Medical Center	Charleston	South Carolina
United States	Focus Clinical Research Solutions	Charlotte	North Carolina
United States	Novant Health - Heart and Vascular Institute	Charlotte	North Carolina
United States	The Presbyterian Hospital	Charlotte	North Carolina
United States	Chattanooga Medical Research, LLC	Chattanooga	Tennessee
United States	Chattanooga Research and Medicine (CHARM)	Chattanooga	Tennessee
United States	University Diabetes & Endocrine Consultants	Chattanooga	Tennessee
United States	WR-ClinSearch, LLC	Chattanooga	Tennessee
United States	Virginia Endocrinology Research	Chesapeake	Virginia
United States	Apex Medical Research, AMR, Inc.	Chicago	Illinois
United States	Cincinnati Veterans Affairs Medical Center	Cincinnati	Ohio
United States	Hometown Urgent Care & Occupational Health	Cincinnati	Ohio
United States	Clearwater Cardiovascular Consultants	Clearwater	Florida
United States	Louis Stokes Cleveland Dept of VA Medical Center	Cleveland	Ohio
United States	Aurora Care Clinic	Costa Mesa	California
United States	West Broadway Clinic	Council Bluffs	Iowa
United States	Cardiovascular Associates Research, LLC	Covington	Louisiana
United States	Partners in Clinical Research	Cumberland	Rhode Island
United States	Atlanta Heart Specialists, LLC	Cumming	Georgia
United States	North Texas Endocrine Center	Dallas	Texas
United States	Protenium Clinical Research	Dallas	Texas
United States	Research Institute of Dallas, P.A.	Dallas	Texas
United States	Synexus Clinical Research US, Inc.	Dallas	Texas
United States	VA Medical Center - Dallas	Dallas	Texas
United States	Daytona Heart Group	Daytona Beach	Florida
United States	VA Medical Center - Atlanta	Decatur	Georgia
United States	Cohen Medical Research Associates, LLC	Delray Beach	Florida
United States	Iowa Diabetes and Endocrinology Research Center, PLC	Des Moines	Iowa
United States	Alta Pharmaceutical Research Center, Inc.	Dunwoody	Georgia
United States	Monmouth Cardiology Associates	Eatontown	New Jersey
United States	Doctors Hospital at Renaissance	Edinburg	Texas
United States	AMCR Institute, Inc.	Escondido	California
United States	Deaconess Clinic	Evansville	Indiana
United States	Synexus Clinical Research US, Inc.	Evansville	Indiana
United States	Utah Cardiology, P.C. (Davis)	Farmington	Utah
United States	AMH Feasterville Family Health Care Center	Feasterville	Pennsylvania
United States	AA MRC LLC Ahmed Arif Medical Research Center	Flint	Michigan
United States	Diabetes and Thyroid Center of Fort Worth	Fort Worth	Texas
United States	Rockwood Medical Clinic	Fort Worth	Texas
United States	Texas Health Physicians Group	Fort Worth	Texas
United States	Texas Health Research & Education Institute	Fort Worth	Texas
United States	University of North Texas Health Science Center	Fort Worth	Texas
United States	Prestige Clinical Research Center	Franklin	Ohio
United States	Malcom Randall VA Medical Center	Gainesville	Florida
United States	New West Physicians, PC	Golden	Colorado
United States	Cardiology Associates of Bellin Health	Green Bay	Wisconsin
United States	Medication Management, LLC	Greensboro	North Carolina
United States	Triad Clinical Trials, LLC	Greensboro	North Carolina
United States	Mountain View Clinical Research, Inc.	Greer	South Carolina
United States	Fundamental Research, LLC	Gulf Shores	Alabama
United States	Clinical Investigation Specialists, Inc.	Gurnee	Illinois
United States	Pentucket Medical Associates	Haverhill	Massachusetts
United States	Synexus Clinical Research US, Inc.	Henderson	Nevada
United States	Clinical Trials of America-NC, LLC	Hickory	North Carolina
United States	PMG Research of Hickory, LLC	Hickory	North Carolina
United States	Edward Hines Jr. VA Hospital	Hines	Illinois
United States	Pines Clinical Research, Inc.	Hollywood	Florida
United States	Homestead Cardiac & Vein Center	Homestead	Florida
United States	Associates in Medicine	Houston	Texas
United States	East Texas Cardiology PA	Houston	Texas
United States	Endocrine Associates, LLC	Houston	Texas
United States	Heights Doctors Clinic	Houston	Texas
United States	Michael E. DeBakey VA Medical Center	Houston	Texas
United States	Southwest Clinical Trials	Houston	Texas
United States	National Institute of Clinical Research	Huntington Beach	California
United States	Protenium Clinical Research	Hurst	Texas
United States	Medstar Health Research Institute	Hyattsville	Maryland
United States	Piedmont Research Partners	Indian Land	South Carolina
United States	VA Medical Center - Indianapolis	Indianapolis	Indiana
United States	GV Montgomery VA Medical Center	Jackson	Mississippi
United States	Jacksonville Center for Clinical Research	Jacksonville	Florida
United States	Westside Center for Clinical Research	Jacksonville	Florida
United States	Health Awareness, Inc.	Jupiter	Florida
United States	Kalispell Regional Medical Center dba Glacier View Research Institute	Kalispell	Montana
United States	Kansas City VA Medical Center	Kansas City	Missouri
United States	University of Kansas Medical Center Research Institute, Inc.	Kansas City	Kansas
United States	Clinical Investigation Specialists Inc	Kenosha	Wisconsin
United States	Holston Medical Group, P.C.	Kingsport	Tennessee
United States	Metro Knoxville HMA, LLC	Knoxville	Tennessee
United States	Mayo Clinic Health System	La Crosse	Wisconsin
United States	Centex Studies Inc.	Lake Charles	Louisiana
United States	Meridien Research	Lakeland	Florida
United States	Sparrow Clinical Research Institute	Lansing	Michigan
United States	Clearwater Cardiovascular & Interventional Consultants	Largo	Florida
United States	Red Rock Clinical Research LLC	Las Vegas	Nevada
United States	VA Eastern Kansas Health Care	Leavenworth	Kansas
United States	Family Medical Associates	Levittown	Pennsylvania
United States	The Research Group of Lexington, LLC	Lexington	Kentucky
United States	Ocean State Clinical Research Partners	Lincoln	Rhode Island
United States	NJ Heart	Linden	New Jersey
United States	Main Street Physician's Care - Waterway	Little River	South Carolina
United States	Central Arkansas Veterans Healthcare System	Little Rock	Arkansas
United States	Southwest Family Medicine	Littleton	Colorado
United States	VA Loma Linda Healthcare System	Loma Linda	California
United States	VA Long Beach Healthcare System	Long Beach	California
United States	Eastside Clinical Research Associates	Los Angeles	California
United States	VA Greater Los Angeles Healthcare System	Los Angeles	California
United States	Richard S. Cherlin, MD	Los Gatos	California
United States	Robley Rex VA Medical Center	Louisville	Kentucky
United States	Meriter Medical Group, Inc.	Madison	Wisconsin
United States	Carient Heart and Vascular	Manassas	Virginia
United States	Craig S Thompson MD LLC	Marion	Ohio
United States	Heart Clinic of Southern Oregon	Medford	Oregon
United States	VA Medical Center - Memphis	Memphis	Tennessee
United States	Synexus Clinical Research US, Inc.	Mesa	Arizona
United States	Advanced Medical Research Institute	Miami	Florida
United States	University of Miami	Miami	Florida
United States	South Shore Internal Medicine Associates	Milton	Massachusetts
United States	Zablocki VA Medical Center	Milwaukee	Wisconsin
United States	Winthrop Cardiology Associates	Mineola	New York
United States	Minneapolis Heart Institute Foundation	Minneapolis	Minnesota
United States	Mobile Heart Specialists, PC	Mobile	Alabama
United States	Research Institute of the Carolinas, PLC	Mooresville	North Carolina
United States	Diabetes and Endocrinology Consultants	Morehead City	North Carolina
United States	Cardiovascular Research of Northwest Indiana, LLC	Munster	Indiana
United States	Family Medicine of Sayebrook	Myrtle Beach	South Carolina
United States	Southern New Hampshire Diabetes and Endocrinology	Nashua	New Hampshire
United States	Tennessee Valley Healthcare System	Nashville	Tennessee
United States	Icahn School of Medicine at Mount Sinai	New York	New York
United States	Cardiology Physicians, PA	Newark	Delaware
United States	Advocate Health and Hospitals Corp	Normal	Illinois
United States	Intend Research	Norman	Oklahoma
United States	Lynn Institute of Norman	Norman	Oklahoma
United States	Captain James A. Lovell Federal Health Care Center	North Chicago	Illinois
United States	Northridge Clinical Research Inc.	Northridge	California
United States	Morgan Medical Management & Consultants Inc.	Ocala	Florida
United States	Ocala Research Institute, Inc.	Ocala	Florida
United States	Endocrine Associates of Florida	Ocoee	Florida
United States	Oklahoma City Clinic - Central	Oklahoma City	Oklahoma
United States	South Oklahoma Heart Research Group	Oklahoma City	Oklahoma
United States	Specialty Physicians of Illinois	Olympia Fields	Illinois
United States	University of Nebraska Medical Center	Omaha	Nebraska
United States	VA Nebraska-Western Iowa Health Care System	Omaha	Nebraska
United States	Research Physicians Network Alliance	Orlando	Florida
United States	Palo Alto Division	Palo Alto	California
United States	Synexus Clinical Research US, Inc.	Papillion	Nebraska
United States	Huntington Hospital - Research Department	Pasadena	California
United States	Houston Methodist Research Institute - CCAT Pearland	Pearland	Texas
United States	Andres Patron, D.O., P.A	Pembroke Pines	Florida
United States	DBC Research, Corp	Pembroke Pines	Florida
United States	Langhorne Cardiology Consultants, Inc.	Pensacola	Florida
United States	Arizona Arthritis & Rheumatology Research, PLLC	Peoria	Arizona
United States	Phoenix Veterans Adminstration Health Care System	Phoenix	Arizona
United States	Synexus Clinical Research US, Inc.	Phoenix	Arizona
United States	Pinehurst Medical Clinic Inc	Pinehurst	North Carolina
United States	Preferred Primary Care Physicians	Pittsburgh	Pennsylvania
United States	VA Pittsburgh Healthcare System	Pittsburgh	Pennsylvania
United States	Clinical Investigations of Texas	Plano	Texas
United States	Providence Veteran Administration Medical Center	Providence	Rhode Island
United States	PMG Research of Raleigh, LLC	Raleigh	North Carolina
United States	Rancho Cucamonga Clinical Research	Rancho Cucamonga	California
United States	VA Sierra Nevada Health Care System	Reno	Nevada
United States	Synexus Clinical Research US, Inc.	Richfield	Minnesota
United States	Clinical Research Partners, LLC	Richmond	Virginia
United States	McGuire DVA Medical Center	Richmond	Virginia
United States	The Valley Hospital	Ridgewood	New Jersey
United States	Roanoke Heart Institute	Roanoke	Virginia
United States	PMG Research of Rocky Mount, LLC	Rocky Mount	North Carolina
United States	Clearwater Cardiovascular Consultants	Safety Harbor	Florida
United States	Covenant Medical Center, Inc.	Saginaw	Michigan
United States	CentraCare Heart & Vascular	Saint Cloud	Minnesota
United States	Synexus Clinical Research US, Inc.	Saint Louis	Missouri
United States	HealthEast Medical Research Institute	Saint Paul	Minnesota
United States	Professional Health Care of Pinellas	Saint Petersburg	Florida
United States	Delmarva Heart Research Foundation, Inc.	Salisbury	Maryland
United States	PMG Research of Salisbury, LLC	Salisbury	North Carolina
United States	Bandera Family Healthcare Research LLC	San Antonio	Texas
United States	Briggs Clinical Research, LLC.	San Antonio	Texas
United States	Consano Clinical Research, LLC	San Antonio	Texas
United States	Sant Antonio Premiere Internal Medicine	San Antonio	Texas
United States	Schnitzler Cardiovascular Consultants (SCC), PLLC	San Antonio	Texas
United States	MD Strategies Research Centers	San Diego	California
United States	Alex Harrison, MD Inc.	Santa Maria	California
United States	Santa Rosa Cardiology Medical Group, Inc.	Santa Rosa	California
United States	Northeast Clinical Research of San Antonio	Schertz	Texas
United States	Fay West Family Practice	Scottdale	Pennsylvania
United States	Carolina Research Center, Inc.	Shelby	North Carolina
United States	Overton Brooks VA Medical Center	Shreveport	Louisiana
United States	Montgomery Medical Inc.	Smithfield	Pennsylvania
United States	Palmetto Research Center, LLC	Spartanburg	South Carolina
United States	Spring Family Practice Associates	Spring	Texas
United States	Suffolk Multispecialty Research	Suffolk	Virginia
United States	Palmetto Clinical Research	Summerville	South Carolina
United States	Clinical Research Institute of Arizona, LLC	Surprise	Arizona
United States	SUNY Upstate Medical University	Syracuse	New York
United States	VA Medical Center - Syracuse	Syracuse	New York
United States	James A. Haley VA Medical Center	Tampa	Florida
United States	Northwest Houston Heart Center	Tomball	Texas
United States	Atlanta Heart Specialists, LLC	Tucker	Georgia
United States	Eclipse Clinical Research	Tucson	Arizona
United States	Synexus Clinical Research US, Inc.	Tucson	Arizona
United States	Terence T. Hart, MD	Tuscumbia	Alabama
United States	Buynak Clinical Research	Valparaiso	Indiana
United States	Victoria Heart & Vascular Center	Victoria	Texas
United States	Corporation Lane Internal Medicine	Virginia Beach	Virginia
United States	Blue Coast Cardiology	Vista	California
United States	Hillcrest Family Health Clinics	Waco	Texas
United States	Chase Medical Research, LLC	Waterbury	Connecticut
United States	The Iowa Clinic, PC	West Des Moines	Iowa
United States	VA Connecticut Healthcare Sys	West Haven	Connecticut
United States	VA Medical Center	White River Junction	Vermont
United States	Clinical Research of Central Florida	Winter Haven	Florida

Sponsors (2)

Lead Sponsor	Collaborator
Kowa Research Institute, Inc.	Brigham and Women's Hospital

Countries where clinical trial is conducted

United States,  Argentina,  Brazil,  Bulgaria,  Canada,  Colombia,  Czechia,  Denmark,  France,  Germany,  Hungary,  India,  Israel,  Japan,  Mexico,  Netherlands,  Poland,  Puerto Rico,  Romania,  Russian Federation,  Slovakia,  South Africa,  Spain,  Ukraine,  United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of patients with first occurrence of nonfatal MI, nonfatal ischemic stroke, coronary revascularization, or CV death.		Through study completion, an average of 4 years
Secondary	Time to first occurrence of The 4-component composite endpoint of non-fatal MI, non-fatal ischemic stroke, hospitalization for unstable angina requiring unplanned coronary revascularization or cardiovascular death		Through study completion, an average of 4 years
Secondary	Time to first occurrence of the 3-component composite endpoint of non-fatal MI, non-fatal ischemic stroke, or cardiovascular death		Through study completion, an average of 4 years
Secondary	Time to first occurrence of any component of the primary endpoint or hospitalization for Heart failure (HF)		Through study completion, an average of 4 years
Secondary	Time to first occurrence of any component of the primary endpoint or all-cause mortality		Through study completion, an average of 4 years
Secondary	Time to first occurrence of any new or worsening Peripheral artery disease (PAD)	Any new or worsening Peripheral artery disease (PAD), defined as incidence of lower extremity revascularization, intermittent claudication, rest pain, lower extremity ischemic ulceration, or major amputation with either ankle-brachial index = 0.9 or other diagnostic testing (eg, toe-brachial index, angiogram, or other imaging study)	Through study completion, an average of 4 years
Secondary	Time of first occurrence of individual endpoints and an analysis of total events	(evaluating time to occurrence of the first and all recurrent non-fatal MI, non-fatal ischemic stroke, coronary revascularization, or cardiovascular death).	Through study completion, an average of 4 years
Secondary	Incidence of cardiovascular events	Effect of pemafibrate vs placebo on cardiovascular events compared to known genetic polymorphisms in the PPARA gene	Up to 4 Years
Secondary	Lipid Endpoints	The change from Screening/Enrollment Visit (Visit 1) to Month 4 Visit (Visit 5) for the following lipid biomarkers: Total cholesterol (TC), Triglyceride(s) (TG), High-density lipoprotein cholesterol (HDL-C), non-HDL-C (calculated), Very low-density lipoprotein cholesterol (VLDL-C) (calculated), ApoA1, ApoC3, and ApoE	Week -3 to Month 4 (Visit 1 to Visit 5)
Secondary	Nonfasting Remnant Cholesterol Endpoint	The change from Randomization Visit (Visit 2) to Month 6 Visit (Visit 6) for nonfasting remnant cholesterol	Week 0 to Month 6 (Visit 2 to Visit 6)