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Functional Connectivity Measurement After Severe Traumatic Brain Injury — Connectivite  

Disorder of Consciousness Clinical Trial

Official title:
Functional Connectivity Measurement After Severe Traumatic Brain Injury

Clinical Trial Summary

To compare functional connectivity after severe traumatic brain injury (TBI) between a group of post-comatose TBI with restored consciousness and a group of post-comatose TBI with persistant disorder of consciousness at admission in rehabilitation

Clinical Trial Description

Recovery of consciousness can be impaired in severe traumatic brain injury (TBI). Prognostic factors are sparse and mostly clinical (mainly the initial Glasgow coma scale GCS) (1). Functional magnetic resonance imaging (fMRI) could allow a better understanding of functional recovery. Graph method has been applied to fMRI signal analysis in disorder of consciousness (DOC) due to post-anoxic encephalopathy. Comatose state was characterized by dramatic change in local connectivity (hub location) without significant change in global connectivity (2). The present study aims at describing functional connectivity in DOC following severe TBI. We will record resting state fMRI in TBI patients in two clinical conditions: conscious state versus DOC state. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02647996
Study type Observational
Source University Hospital, Grenoble
Contact
Status Completed
Phase
Start date March 2015
Completion date October 2019
View Details
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